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Issue 34, 2016
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Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications

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Abstract

Poly(N,N-dimethylaminoethyl methacrylate)-block-poly(L-lactic acid)-block-poly(N,N-dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. These non-aggregating polymers showed low MIC values against Gram-negative and Gram-positive, including methicillin-resistant Staphylococcus aureus (MRSA), bacteria. The polymers exhibited minimal toxicity and are promising antibacterial agents for biomedical applications.

Graphical abstract: Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications

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Publication details

The article was received on 20 Feb 2016, accepted on 14 Mar 2016 and first published on 15 Mar 2016


Article type: Paper
DOI: 10.1039/C6RA04531F
Citation: RSC Adv., 2016,6, 28947-28955
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    Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications

    Z. Li, P. L. Chee, C. Owh, R. Lakshminarayanan and X. J. Loh, RSC Adv., 2016, 6, 28947
    DOI: 10.1039/C6RA04531F

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