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Themed collection Chemosensors and Molecular Logic

57 items
Feature Article

Intracellular temperature measurements with fluorescent polymeric thermometers

Intracellular temperature can be measured using fluorescent polymeric thermometers via their temperature-dependent fluorescence signals.

Graphical abstract: Intracellular temperature measurements with fluorescent polymeric thermometers
From the themed collection: Chemosensors and Molecular Logic
Open Access Feature Article

Fluorescent glycoprobes: a sweet addition for improved sensing

We highlight recent progress from our labs for the development of fluorescent glycoprobes for sensing ions/lectins and targeted detection of intracellular species, including the construction of their 2D material composites for targeted fluorescence imaging and theranostics.

Graphical abstract: Fluorescent glycoprobes: a sweet addition for improved sensing
From the themed collection: Chemosensors and Molecular Logic
Open Access Tutorial Review

Fluorescent chemosensors: the past, present and future

Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences.

Graphical abstract: Fluorescent chemosensors: the past, present and future
From the themed collection: Chemosensors and Molecular Logic
Critical Review

pH-Sensing fluorescence oligonucleotide probes based on an i-motif scaffold: a review

Fluorescent i-motif based sensors as promising tools for cellular pH-sensing and bioimaging.

Graphical abstract: pH-Sensing fluorescence oligonucleotide probes based on an i-motif scaffold: a review
From the themed collection: Chemosensors and Molecular Logic
Communication

Monitoring of Au(III) species in plants using a selective fluorescent probe

A colorimetric and ratiometric probe with a push–pull chromophore dicyanoisophorone system, AuP, has been developed for the detection of Au(III) species with highly sensitive and selective response to real-water samples and living tissues of Arabidopsis thaliana.

Graphical abstract: Monitoring of Au(iii) species in plants using a selective fluorescent probe
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Azulene–boronate esters: colorimetric indicators for fluoride in drinking water

Sensitive and selective fluoride indicators consisting of a boronate ester receptor motif, conjugated to an azulene reporter motif, are described. These exhibit a colour change visible to the naked eye when exposed to fluoride.

Graphical abstract: Azulene–boronate esters: colorimetric indicators for fluoride in drinking water
From the themed collection: Chemosensors and Molecular Logic
Communication

Supramolecular coordination polymers using a close to ‘V-shaped’ fluorescent 4-amino-1,8-naphthalimide Tröger's base scaffold

A novel 4-amino-1,8-naphthalimide derived Tröger's base ligand L has been synthesised and subsequently used in the formation of two new supramolecular coordination polymers TB-Co-CP and TB-Cd-CP.

Graphical abstract: Supramolecular coordination polymers using a close to ‘V-shaped’ fluorescent 4-amino-1,8-naphthalimide Tröger's base scaffold
From the themed collection: Chemosensors and Molecular Logic
Communication

Multifunctional logic gate by means of a triple-chromophore fluorescent biothiol probe with diverse fluorescence signal patterns

From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2).

Graphical abstract: Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Protein sensing and discrimination using highly functionalised ruthenium(II) tris(bipyridyl) protein surface mimetics in an array format

Ruthenium(II) tris(bipyridyl) protein surface mimetics are used for protein sensing in an array format.

Graphical abstract: Protein sensing and discrimination using highly functionalised ruthenium(ii) tris(bipyridyl) protein surface mimetics in an array format
From the themed collection: Chemosensors and Molecular Logic
Communication

Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection

Robust 1,8-naphthalimide cross-coupling methodology unlocks access to derivatives with interesting photophysical properties and diverse applications.

Graphical abstract: Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

A continuous luminescence assay for monitoring kinase activity: signalling the ADP/ATP ratio using a discrete europium complex

A stable Eu(III) complex is reported that binds reversibly to ATP and ADP, providing a ratiometric luminescent signal that enables the kinase-catalysed conversion of ATP to ADP to be monitored in real-time.

Graphical abstract: A continuous luminescence assay for monitoring kinase activity: signalling the ADP/ATP ratio using a discrete europium complex
From the themed collection: Chemosensors and Molecular Logic
Communication

A naphthalimide-based solid state luminescent probe for ratiometric detection of aluminum ions: in vitro and in vivo applications

A naphthalimide-based solid state luminescent probe has been designed and synthesized for the detection of Al3+ ions in solution as well as in the solid state with its versatile applications as materials and as a bio-imaging tool for the detection of Al3+ ions under in vitro and in vivo milieu.

Graphical abstract: A naphthalimide-based solid state luminescent probe for ratiometric detection of aluminum ions: in vitro and in vivo applications
From the themed collection: Chemosensors and Molecular Logic
Communication

Folded short azapeptide for conformation switching based fluorescent sensing

From the themed collection: Chemosensors and Molecular Logic
Communication

Selenoureas for anion binding as molecular logic gates

The first example of a molecular logic gate based on selenourea/anion host–guest interaction that performs a ternary logic operation using an 1H-NMR easy to read response output is described here.

Graphical abstract: Selenoureas for anion binding as molecular logic gates
From the themed collection: Chemosensors and Molecular Logic
Communication

A highly selective fluorescence turn-on detection of ClO with 1-methyl-1,2-dihydropyridine-2-thione unit modified tetraphenylethylene

A novel fluorescent probe for ClO is developed by the combination of a new ClO responsive unit and the aggregation induced-emission feature of tetraphenylethylene.

Graphical abstract: A highly selective fluorescence turn-on detection of ClO− with 1-methyl-1,2-dihydropyridine-2-thione unit modified tetraphenylethylene
From the themed collection: Chemosensors and Molecular Logic
Communication

A mechanistically-distinct approach to fluorescence visualization of singlet oxygen

1O2 oxidation of a non-fluorescent sulfoxide forms a fluorescent sulfone, with significant (>50-fold) increase in emission. The oxidation occurs via intramolecular oxygen atom transfer from a reactive persulfoxide intermediate. This represents a new, mechanistically-distinct approach to fluorescent 1O2 detection.

Graphical abstract: A mechanistically-distinct approach to fluorescence visualization of singlet oxygen
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

A naphthalimide-based chemosensing motif capable of turning on the fluorescence emission in solution and in vitro is reported.

Graphical abstract: Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy
From the themed collection: Chemosensors and Molecular Logic
Communication

Enhanced detection of explosives by turn-on resonance Raman upon host–guest complexation in solution and the solid state

Being colour coordinated allows turn on detection of nitroaromatics by combining molecular recognition with resonant enhancement of the Raman spectra.

Graphical abstract: Enhanced detection of explosives by turn-on resonance Raman upon host–guest complexation in solution and the solid state
From the themed collection: Chemosensors and Molecular Logic
Communication

TPZ, a bright centrosymmetric two-photon scaffold for bioimaging

The development of biocompatible two-photon fluorophores with a large absorption cross-section is challenging, despite the presence of theoretical guidelines.

Graphical abstract: TPZ, a bright centrosymmetric two-photon scaffold for bioimaging
From the themed collection: Chemosensors and Molecular Logic
Communication

A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

A fluorescent probe enables two-photon ratiometric imaging of endogenous hypochlorous acid, a reactive oxygen species, in cells and tissues.

Graphical abstract: A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues
From the themed collection: Chemosensors and Molecular Logic
Communication

Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Dibenzazepinyl ureas act as probes to allow conformational analysis of screw-sense preference in dynamic foldamers by both NMR and CD spectroscopy.

Graphical abstract: Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers
From the themed collection: Chemosensors and Molecular Logic
Communication

Two fluorescein-based chemosensors for the fast detection of 2,4,6-trinitrophenol (TNP) in water

Two fluorescein-based chemosensors have been developed for the rapid and selective fluorescence detection of 2,4,6-trinitrophenol (TNP) under excitation by visible light.

Graphical abstract: Two fluorescein-based chemosensors for the fast detection of 2,4,6-trinitrophenol (TNP) in water
From the themed collection: Chemosensors and Molecular Logic
Communication

Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide

We developed a fast and selective near-infrared (NIR) fluorescent probe for the targeted tracing of endogenous NO which possesses vital features including a significant turn-on NIR response, high specificity, and a fast response.

Graphical abstract: Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

A bodipy based hydroxylamine sensor

With this research we have developed a bodipy based system as the first “turn-on” fluorescence system for the detection hydroxylamine.

Graphical abstract: A bodipy based hydroxylamine sensor
From the themed collection: Chemosensors and Molecular Logic
Communication

Fluorescent chirality recognition by simple boronate ensembles with aggregation-induced emission capability

Chiral boronate ensembles showed enantioselective aggregation behaviors for chiral diamines and cinchona alkaloids, enabling the fluorescent recognition of their chirality.

Graphical abstract: Fluorescent chirality recognition by simple boronate ensembles with aggregation-induced emission capability
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Ratiometric electrochemical detection of β-galactosidase

A novel ferrocene-based substrate for the ratiometric electrochemical detection of β-galactosidase was designed and synthesised, exhibiting high sensitivity for β-gal.

Graphical abstract: Ratiometric electrochemical detection of β-galactosidase
From the themed collection: Chemosensors and Molecular Logic
Communication

An AIE-based fluorescent test strip for the portable detection of gaseous phosgene

An AIE-based ratiometric fluorescent test strip was developed for portable point-of-use detection of gaseous phosgene.

Graphical abstract: An AIE-based fluorescent test strip for the portable detection of gaseous phosgene
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy

We show that supramolecular core–glycoshell nanodots are capable of targeted imaging and photodynamic therapy of liver and triple-negative breast cancer cells.

Graphical abstract: Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy
From the themed collection: Chemosensors and Molecular Logic
Communication

Acid/base-controllable fluorescent molecular switches based on cryptands and basic N-heteroaromatics

Two kinds of fluorescent BMP32C10-based cryptands 1 and 2 have been developed.

Graphical abstract: Acid/base-controllable fluorescent molecular switches based on cryptands and basic N-heteroaromatics
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Photochromism and molecular logic gate operation of a water-compatible bis-glycosyl diarylethene

The synthesis of a bis-glycosyl diarylethene derivative by click chemistry for the water-compatible photochromism and operation of molecular logic gates is reported.

Graphical abstract: Photochromism and molecular logic gate operation of a water-compatible bis-glycosyl diarylethene
From the themed collection: Chemosensors and Molecular Logic
Communication

Proof of principle of a three-input AND–INHIBIT–OR combinatorial logic gate array

A designed molecule provides a fluorescent signal according to a combinatorial logic array comprised of three-input AND, three-input INHIBIT and two-input OR logic gates.

Graphical abstract: Proof of principle of a three-input AND–INHIBIT–OR combinatorial logic gate array
From the themed collection: Chemosensors and Molecular Logic
Communication

One-step, green synthesis of a supramolecular organogelator based on mellitic triimide for the recognition of aromatic compounds

Mellitic triimide derivatives act as supramolecular gelators, which enable the detection of aromatic molecules as a gel–sol phase transition.

Graphical abstract: One-step, green synthesis of a supramolecular organogelator based on mellitic triimide for the recognition of aromatic compounds
From the themed collection: Chemosensors and Molecular Logic
Communication

2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo

Two 2-nitroimidazole-1,8-naphthalimide conjugates, 1 and 2, have been synthesised as fluorescence probes for the detection of reductive stress in HeLa cells.

Graphical abstract: 2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo
From the themed collection: Chemosensors and Molecular Logic
Communication

A redox-responsive selenium-containing pillar[5]arene-based macrocyclic amphiphile: synthesis, controllable self-assembly in water, and application in controlled release

A selenium-containing pillar[5]arene-based macrocyclic amphiphile was prepared. This amphiphile self-assembled in water to form vesicles with redox responsiveness. Then, these pillar[5]arene-based vesicles were used in the controlled release of DOX.

Graphical abstract: A redox-responsive selenium-containing pillar[5]arene-based macrocyclic amphiphile: synthesis, controllable self-assembly in water, and application in controlled release
From the themed collection: Chemosensors and Molecular Logic
Communication

Selectively switching on europium emission in drug site one of human serum albumin

A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of europium emission, and accompanied by strong induced circularly polarised luminescence.

Graphical abstract: Selectively switching on europium emission in drug site one of human serum albumin
From the themed collection: Chemosensors and Molecular Logic
Communication

A molecular self-assembled colourimetric chemosensor array for simultaneous detection of metal ions in water

An easy-to-prepare chemosensor assay based on molecular self-assemblies of 3-nitrophenylboronic acid and catechol dyes can detect metal ions qualitatively and quantitatively.

Graphical abstract: A molecular self-assembled colourimetric chemosensor array for simultaneous detection of metal ions in water
From the themed collection: Chemosensors and Molecular Logic
Communication

A wash-free SNAP-tag fluorogenic probe based on the additive effects of quencher release and environmental sensitivity

A 1,8-naphthalimide-derived SNAP-tag fluorogenic probe can specifically and rapidly label proteins in live cells without requiring a wash procedure.

Graphical abstract: A wash-free SNAP-tag fluorogenic probe based on the additive effects of quencher release and environmental sensitivity
From the themed collection: Chemosensors and Molecular Logic
Communication

Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

An amidine-based small molecule two-photon fluorescent probe for monitoring vesicle transport from the ER to lysosome in live cells was reported.

Graphical abstract: Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe
From the themed collection: Chemosensors and Molecular Logic
Communication

A tumor-specific and mitochondria-targeted fluorescent probe for real-time sensing of hypochlorite in living cells

The first dual-targeted (both cancer cells and mitochondria) fluorescent probe for sensing mitochondrial hypochlorite was presented and applied in cell imaging.

Graphical abstract: A tumor-specific and mitochondria-targeted fluorescent probe for real-time sensing of hypochlorite in living cells
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

A versatile continuous colorimetric assay for AMACR is reported.

Graphical abstract: A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate
From the themed collection: Chemosensors and Molecular Logic
Communication

A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

A two-photon fluorescent probe based on an ESIPT fluorophore bearing AIE characteristics was utilized to detect H2S.

Graphical abstract: A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics
From the themed collection: Chemosensors and Molecular Logic
Communication

End-to-end assembly and disassembly of gold nanorods based on photo-responsive host–guest interaction

The end-to-end assembly and disassembly of gold nanorods were realized via HS-β-CD recognition and controllable by both UV light irradiation and guest competition.

Graphical abstract: End-to-end assembly and disassembly of gold nanorods based on photo-responsive host–guest interaction
From the themed collection: Chemosensors and Molecular Logic
Communication

A self-assembled amphiphilic imidazolium-based ATP probe

An amphiphilic imidazolium-based self-assembled probe forms aggregates and selectively recognizes aqueous ATP among other bioactive anions with a significant enhancement in fluorescence emission.

Graphical abstract: A self-assembled amphiphilic imidazolium-based ATP probe
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking

Graphene oxide enhances the imaging ability of a cell-impermeable peptide probe that targets microtubules, enabling the dynamic tracking of mitosis in live cells.

Graphical abstract: Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Glucose selective bis-boronic acid click-fluor

Four novel bis-boronic acid compounds were synthesised via copper catalysed azide–alkyne cycloaddition (CuAAC) reactions.

Graphical abstract: Glucose selective bis-boronic acid click-fluor
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

Targeted tumor detection: guidelines for developing biotinylated diagnostics

We highlight the prominent role of hydrophilicity in the preferential cellular uptake process of biotinylated fluorescent probes.

Graphical abstract: Targeted tumor detection: guidelines for developing biotinylated diagnostics
From the themed collection: Chemosensors and Molecular Logic
Open Access Communication

The Bull–James assembly as a chiral auxiliary and shift reagent in kinetic resolution of alkyne amines by the CuAAC reaction

The Bull–James boronic acid assembly is used simultaneously as a chiral auxiliary for kinetic resolution and as a chiral shift reagent for in situ enantiomeric excess (ee) determination by 1H NMR spectroscopy.

Graphical abstract: The Bull–James assembly as a chiral auxiliary and shift reagent in kinetic resolution of alkyne amines by the CuAAC reaction
From the themed collection: Chemosensors and Molecular Logic
Paper

Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose

To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity.

Graphical abstract: Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose
From the themed collection: Chemosensors and Molecular Logic
Paper

A fluorescent combinatorial logic gate with Na+/H+-enabled OR and H+-driven low-medium-high ternary logic functions

From the themed collection: Chemosensors and Molecular Logic
Paper

Differential array sensing for cancer cell classification and novelty detection

A series of semi-specific peptides reported in the literature to bind various epitopes on cell surfaces were used in a differential sensing array to pattern cell line identity.

Graphical abstract: Differential array sensing for cancer cell classification and novelty detection
From the themed collection: Chemosensors and Molecular Logic
Paper

Selective recognition of biologically important anions using a diblock polyfluorene–polythiophene conjugated polyelectrolyte

Fluorescence detection of nucleotide phosphates with a polyfluorene–polythiophene diblock copolymer is demonstrated, accompanied by determination of the sensor mechanism.

Graphical abstract: Selective recognition of biologically important anions using a diblock polyfluorene–polythiophene conjugated polyelectrolyte
From the themed collection: Chemosensors and Molecular Logic
Paper

Unpicking the determinants of amide NH⋯O[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances

The stereoelectronic properties affecting hydrogen bond strength are investigated with a series of diphenylacetylene-based molecular balances.

Graphical abstract: Unpicking the determinants of amide NH⋯O [[double bond, length as m-dash]] C hydrogen bond strength with diphenylacetylene molecular balances
From the themed collection: Chemosensors and Molecular Logic
Paper

Control of electrostatic interaction between a molecular beacon aptamer and conjugated polyelectrolyte for detection range-tunable ATP assay

A new strategy is suggested to fine-tune the detection range by controlling the ionic density of CPEs in the MBA/CPE-based ATP assay.

Graphical abstract: Control of electrostatic interaction between a molecular beacon aptamer and conjugated polyelectrolyte for detection range-tunable ATP assay
From the themed collection: Chemosensors and Molecular Logic
Paper

A fluorescein-based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging

Relay recognition of copper(II) ions and biothiols via a fluorescence “on–off–on” cascade has been realized in 100% aqueous solution when excited by the visible light.

Graphical abstract: A fluorescein-based chemosensor for relay fluorescence recognition of Cu(ii) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging
From the themed collection: Chemosensors and Molecular Logic
Open Access Research Article

Reaction-based indicator displacement assay (RIA) for the colorimetric and fluorometric detection of hydrogen peroxide

Reaction-based indicator displacement assay for the optical cycle-monitoring of hydrogen peroxide.

Graphical abstract: Reaction-based indicator displacement assay (RIA) for the colorimetric and fluorometric detection of hydrogen peroxide
From the themed collection: Chemosensors and Molecular Logic
Open Access Research Article

Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides

We show that low-dimensional materials enhance the conjugation between fluorogenic phenylboronic acids and saccharides.

Graphical abstract: Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides
From the themed collection: Chemosensors and Molecular Logic
57 items

About this collection

This collection guest edited by Tony James (University of Bath), Thorfinnur Gunnlaugsson (Trinity College Dublin), Juyoung Yoon (Ewha Womans University), and Engin Akkaya (Bilkent University) aims to highlight the current state of the art and future directions in the two closely linked fields of Chemosensors and Molecular Logic.
Anthony W. Czarnik (21-11-1957), in an ACS Symposium Series publication on “Fluorescent Chemosensors for Ion and Molecule Recognition” (DOI: 10.1021/bk-1993-0538), started the field of “Chemosensors” with these illuminating words “a fluorescent chemosensor is a compound of abiotic origin that complexes to an analyte reversibly with concomitant fluorescence signal. The technological driving force to achieve useful chemosensors will stimulate investigation of new topics in molecule recognition, fluorescent signal transduction, and their intersection.” 
AP De Silva (29-4-1952) in his RSC Monograph on “Molecular Logic-based Computation” (DOI: 10.1039/9781849733021) described “Molecular Logic” as “a growing branch of chemical science which highlights the connection between information technology (engineering and biological) and chemistry.”
We are certain that this web-collection will provide a resource facilitating and promoting the adventures that lie ahead in the linked areas of Chemosensors and Molecular Logic.

Find out more about Tony Czarnik and AP de Silva and read our interviews with them.

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