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A Mechanistically-Distinct Approach to Fluorescence Visualization of Singlet Oxygen.

Abstract

We report a method for the fluorescence-based detection of singlet oxygen that is orthogonal to previous efforts in the field. It relies on oxidation of a non-fluorescent pyrenyl sulfoxide pro-fluorophore to a fluorescent sulfone, providing a significant (> 50-fold) increase in emission. This oxidation occurs via intramolecular oxygen atom transfer from a persulfoxide intermediate, which is formed when singlet oxygen is trapped by reaction with a pendant sulfide auxiliary group. This mechanistically distinct approach embodies our ongoing efforts to develop new signaling mechanisms for fluorescent probe development, is complementary to known methods, and is the subject of ongoing optimization for biological imaging.

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Publication details

The article was received on 10 Aug 2017, accepted on 13 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06214A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    A Mechanistically-Distinct Approach to Fluorescence Visualization of Singlet Oxygen.

    N. Finney and L. Yang, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC06214A

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