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Issue 98, 2017
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Folded short azapeptide for conformation switching-based fluorescence sensing

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Abstract

Herein, we report a conformation switching-based fluorescence sensing scheme using dipeptide-based amidothioureas (azapeptides) that contain a folded β-turn structure. Amidothiourea is equipped at its two termini with an electron acceptor and an electron donor or two fluorophores, such that it exhibits enhanced exciplex or excimer emission because of the turn structure in which the two termini are brought into close proximity; on the other hand, it exhibits a dramatic ratiometric fluorescence response upon anion binding to the thiourea moiety because of the resultant extended conformation of the anion binding complex.

Graphical abstract: Folded short azapeptide for conformation switching-based fluorescence sensing

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Publication details

The article was received on 04 Sep 2017, accepted on 08 Nov 2017 and first published on 08 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC06915D
Citation: Chem. Commun., 2017,53, 13137-13140
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    Folded short azapeptide for conformation switching-based fluorescence sensing

    Y. Yuan, X. Yan, X. Li, J. Cao, Z. Li and Y. Jiang, Chem. Commun., 2017, 53, 13137
    DOI: 10.1039/C7CC06915D

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