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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

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Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

Graphical abstract: Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

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Publication details

The article was received on 10 Oct 2017, accepted on 03 Nov 2017 and first published on 08 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07845E
Citation: Chem. Commun., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

    A. C. Sedgwick, H. Han, J. E. Gardiner, S. D. Bull, X. He and T. D. James, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07845E

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