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A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

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Abstract

Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a “turn-on” fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.

Graphical abstract: A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

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Publication details

The article was received on 05 Mar 2017, accepted on 04 Apr 2017 and first published on 04 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01695F
Citation: Chem. Commun., 2017, Advance Article
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    A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

    L. Chen, D. Wu, C. S. Lim, D. Kim, S. Nam, W. Lee, G. Kim, H. M. Kim and J. Yoon, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01695F

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