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Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

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Abstract

We report an amidine-based small molecule two-photon fluorescent probe (ELP1) for monitoring vesicle transport from the ER to lysosome in live cells. Two-photon microscopy imaging studies indicated that this probe initially localized in the ER and subsequently transferred to lysosomal compartments through vesicular transport. These results may provide an effective tool for studying trafficking-related biology and pathology in real-time.

Graphical abstract: Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

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Publication details

The article was received on 27 Feb 2017, accepted on 15 May 2017 and first published on 15 May 2017


Article type: Communication
DOI: 10.1039/C7CC01518F
Citation: Chem. Commun., 2017, Advance Article
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    Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

    H. W. Lee, M. K. Cho, H. Kim, C. S. Lim, C. Kang and H. M. Kim, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01518F

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