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Issue 81, 2017
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Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

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Abstract

A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.

Graphical abstract: Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

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Publication details

The article was received on 04 Jul 2017, accepted on 01 Sep 2017 and first published on 01 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05166B
Citation: Chem. Commun., 2017,53, 11161-11164
  • Open access: Creative Commons BY license
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    Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

    M. Li, H. Ge, V. Mirabello, R. L. Arrowsmith, G. Kociok-Köhn, S. W. Botchway, W. Zhu, S. I. Pascu and T. D. James, Chem. Commun., 2017, 53, 11161
    DOI: 10.1039/C7CC05166B

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