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Issue 78, 2017
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A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

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Abstract

A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.

Graphical abstract: A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

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Publication details

The article was received on 26 Jul 2017, accepted on 06 Sep 2017 and first published on 06 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05834A
Citation: Chem. Commun., 2017,53, 10800-10803
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    A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

    Y. W. Jun, S. Sarkar, S. Singha, Y. J. Reo, H. R. Kim, J. Kim, Y. Chang and K. H. Ahn, Chem. Commun., 2017, 53, 10800
    DOI: 10.1039/C7CC05834A

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