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Themed collection 2017 Journal of Materials Chemistry B HOT Papers

59 articles
Review Article

Cultured cell-derived decellularized matrices: a review towards the next decade

Summary of recent progress in cell-derived decellularized matrices preparation and application, with perspectives towards the next decade.

Graphical abstract: Cultured cell-derived decellularized matrices: a review towards the next decade
Review Article

Thermo-responsive polymers and their application as smart biomaterials

This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical and biomaterials applications.

Graphical abstract: Thermo-responsive polymers and their application as smart biomaterials
Review Article

Physical principles of graphene cellular interactions: computational and theoretical accounts

Clarifying the physical principles of graphene cellular interactions is critical for the wider application of graphene-based nanomaterials in nanomedicine. This review highlights the advances in computational and theoretical accounts for this emerging field.

Graphical abstract: Physical principles of graphene cellular interactions: computational and theoretical accounts
Review Article

Engineering strategies for chitin nanofibers

Chitin nanofibers are the fundamental building blocks of numerous structural natural materials. From top-down to bottom-up, here we review engineering strategies to produce chitin nanofibers for engineered materials and their applications.

Graphical abstract: Engineering strategies for chitin nanofibers
Review Article

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Here we define hydrogels crosslinked by weak bonds as physical hydrogels.

Graphical abstract: Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications
Review Article

Targeting fibronectin for cancer imaging and therapy

During cancer progression, the extracellular matrix (ECM) undergoes dramatic changes, which promote cancer cell migration and invasion.

Graphical abstract: Targeting fibronectin for cancer imaging and therapy
Review Article

Cyclodextrin-based supramolecular nanoparticles for biomedical applications

This review on cyclodextrin-based supramolecular nanoparticles presents the different forces involved in particle formation and their diagnostic and therapeutic applications.

Graphical abstract: Cyclodextrin-based supramolecular nanoparticles for biomedical applications
Review Article

Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses

This review summarizes a pool of current experimental approaches and discusses perspectives in the development of the synergistic combination of shape and stimuli-response in particulate hydrogels.

Graphical abstract: Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses
Communication

Natural extracted aerogels with inherent anisotropy and their 3D printing assisted biomedical applications

Exemplified with jackfruit and sugarcane, natural extracted aerogels with inherent structural anisotropy were investigated for the first time.

Graphical abstract: Natural extracted aerogels with inherent anisotropy and their 3D printing assisted biomedical applications
Communication

Temporal and spatial programming in soft composite hydrogel objects

A spatial and temporal response of hydrogel objects is demonstrated using an enzyme as a programming tool.

Graphical abstract: Temporal and spatial programming in soft composite hydrogel objects
Communication

Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation

Thermoresponsive convex or concave substrates were developed as functional cell separation materials by the combination of thermal nano-imprinted lithography and subsequent surface-initiated ATRP of PIPAAm.

Graphical abstract: Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation
Paper

A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages (TAMs)

Paper

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers

A dramatic enhancement in the glycosidase multivalent inhibitory effect was observed while going from a dodecavalent iminosugar ball to the corresponding giant molecule with 120 peripheral subunits.

Graphical abstract: Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers
Paper

Implementation of a stratified approach and gene immobilization to enhance the osseointegration of a silk-based ligament graft

Integration of a stratified approach and gene immobilization promotes silk-based ACL interface formation, expanding the therapeutic potential of a silk-based ligament graft.

Graphical abstract: Implementation of a stratified approach and gene immobilization to enhance the osseointegration of a silk-based ligament graft
Paper

Silicate-based bioceramics regulating osteoblast differentiation through BMP2 signalling pathway

Paper

Effect of hydrogel material composition on hBMSC differentiation into zone-specific neo-cartilage: engineering human articular cartilage-like tissue with spatially varying properties

Material composition alone can be used to direct human bone marrow stromal cells into distinct, zone-specific cell phenotypes and spatially-varying, multi-layered material scaffolds can generate complex, patterned tissue structures.

Graphical abstract: Effect of hydrogel material composition on hBMSC differentiation into zone-specific neo-cartilage: engineering human articular cartilage-like tissue with spatially varying properties
Paper

Stacking modular DNA circuitry in cascading self-assembly of spherical nucleic acids

Integrated circuitries are successfully built through using the cascaded modular strategy with the assistance of stochastic simulations.

Graphical abstract: Stacking modular DNA circuitry in cascading self-assembly of spherical nucleic acids
Paper

Preparation of dexamethasone-loaded calcium phosphate nanoparticles for the osteogenic differentiation of human mesenchymal stem cells

Dexamethasone (DEX)-loaded biphasic calcium phosphate nanoparticles (BCP-NPs) are prepared by incorporation of DEX during or after the formation of BCP-NPs. The DEX-loaded BCP-NPs release DEX in a sustained manner and enhance the osteogenic differentiation of hMSCs.

Graphical abstract: Preparation of dexamethasone-loaded calcium phosphate nanoparticles for the osteogenic differentiation of human mesenchymal stem cells
Paper

Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy

Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cancer cells.

Graphical abstract: Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy
Paper

Facile fabrication of a resveratrol loaded phospholipid@reduced graphene oxide nanoassembly for targeted and near-infrared laser-triggered chemo/photothermal synergistic therapy of cancer in vivo

A resveratrol-loaded phospholipid coated reduced graphene oxide was prepared using a sonication method.

Graphical abstract: Facile fabrication of a resveratrol loaded phospholipid@reduced graphene oxide nanoassembly for targeted and near-infrared laser-triggered chemo/photothermal synergistic therapy of cancer in vivo
Paper

Influence of microporous gelatin hydrogels on chondrocyte functions

Gelatin hydrogels with microporous structures were prepared by polymerization of GelMAGMA macromers and dissolution of gelatin hydrogel microcubes. The microporous gelatin hydrogels promoted proliferation of chondrocytes and showed different cellular effects compared to hydrogels without microporous structures.

Graphical abstract: Influence of microporous gelatin hydrogels on chondrocyte functions
Paper

A novel transparent luminous hydrogel with self-healing property

A Luminous hydrogel with self-healing properties and biocompatibility was synthesized by a Eu-containing PVA with boric acid as a cross-linking agent.

Graphical abstract: A novel transparent luminous hydrogel with self-healing property
Paper

An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio

Reversible networks are a key factor for designing self-healing hydrogels with high stretching properties.

Graphical abstract: An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio
Paper

Conducting hydrogels for edible electrodes

Conducting hydrogels prepared from edible, commercially available materials were shown to function as capacitive pressure sensors.

Graphical abstract: Conducting hydrogels for edible electrodes
Paper

Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for β-galactosidase activity monitoring

The self-assembly of CuNCs was driven by aluminum cations and they had a sensing application in the monitoring of β-galactosidase activity.

Graphical abstract: Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for β-galactosidase activity monitoring
Paper

Chondrogenic differentiation of BMSCs encapsulated in chondroinductive polysaccharide/collagen hybrid hydrogels

Although BMSC-based therapy is one of the most front-line technologies for cartilage repair, it is still a big challenge to attain ideal niches for BMSC chondrogenic differentiation.

Graphical abstract: Chondrogenic differentiation of BMSCs encapsulated in chondroinductive polysaccharide/collagen hybrid hydrogels
Paper

A core–shell structured polyplex for efficient and non-toxic gene delivery

We developed a core–shell polyplex with minimal high generation dendrimer to condense DNA and low-molecular-weight linear polyethylenimine coated on the core. The polyplex represented both high transfection efficacy and low toxicity.

Graphical abstract: A core–shell structured polyplex for efficient and non-toxic gene delivery
Paper

Multifunctional Cu39S28 hollow nanopeanuts for in vivo targeted photothermal chemotherapy

This work represents a one-step direct aqueous method to synthesize Cu39S28 hollow nanopeanuts towards ultrasensitive tumor targeted photothermal chemotherapy.

Graphical abstract: Multifunctional Cu39S28 hollow nanopeanuts for in vivo targeted photothermal chemotherapy
Paper

RGD/CTX-conjugated multifunctional Eu–Gd2O3 NRs for targeting detection and inhibition of early tumor

The multifunctional Eu–Gd2O3 nanorods (NRs) with targeting/limitation of early glioblastoma and enhancements of in vivo MR and luminescence imaging were fabricated through a hydrothermal-calcination, PEGylation and thiolation conjugation of arginine–glycine–aspartic (RGD) and chlorotoxin (CTX).

Graphical abstract: RGD/CTX-conjugated multifunctional Eu–Gd2O3 NRs for targeting detection and inhibition of early tumor
Paper

Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy

The multidrug co-loaded injectable hydrogels against tumor showed superiority and potential application values.

Graphical abstract: Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy
Paper

A porous sodium polyacrylate-grafted chitosan xerogel for severe hemorrhage control synthesized from one-pot reaction

In this study, we fabricated a SPA-co-CTS sponge and demonstrated a fast and powerful hemostatic effect both in vitro and in vivo, which was a promising first-aid device for severe hemorrhage control.

Graphical abstract: A porous sodium polyacrylate-grafted chitosan xerogel for severe hemorrhage control synthesized from one-pot reaction
Paper

Lanthanide-doped LaOBr nanocrystals: controlled synthesis, optical spectroscopy and bioimaging

A new bioprobe based on lanthanide-doped LaOBr NCs exhibiting distinct upconversion/downshifting luminescence was explored and demonstrated for in vitro cancer cell imaging.

Graphical abstract: Lanthanide-doped LaOBr nanocrystals: controlled synthesis, optical spectroscopy and bioimaging
Paper

A label-free visual platform for self-correcting logic gate construction and sensitive biosensing based on enzyme-mimetic coordination polymer nanoparticles

We proposed a label-free visual platform based on Cu–GMP CPNs for both self-correcting molecular logic gate construction and sensitive biosensing.

Graphical abstract: A label-free visual platform for self-correcting logic gate construction and sensitive biosensing based on enzyme-mimetic coordination polymer nanoparticles
Paper

Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA

Nanostructured RNA carrying three different siRNAs was assembled to silence three target genes (Axin, APC, and GSK-3β) in the Wnt/β-catenin signaling pathway. This nanostructured ‘3-in-1’ siRNA showed high activity at a low concentration due to the long-term resistance, and enhancing the effect of RNA interference.

Graphical abstract: Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA
Paper

Albumin-mediated platinum nanocrystals for in vivo enhanced computed tomography imaging

Albumin-mediated ultrasmall platinum nanocrystals were fabricated for both in vitro and in vivo enhanced computed tomography imaging.

Graphical abstract: Albumin-mediated platinum nanocrystals for in vivo enhanced computed tomography imaging
Paper

N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

N,S-CDs display an unambiguous bioimaging ability in the detection of intracellular temperature and tetracycline with satisfactory results.

Graphical abstract: N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline
Paper

Extracellular matrix powder from cultured cartilage-like tissue as cell carrier for cartilage repair

Efficiently cultivating cartilage decellularized matrix powder by a 3D culture method for cartilage repair in rabbit osteochondral defects.

Graphical abstract: Extracellular matrix powder from cultured cartilage-like tissue as cell carrier for cartilage repair
Paper

Injectable bioactive akermanite/alginate composite hydrogels for in situ skin tissue engineering

Injectable bioactive SA/Aker hydrogels formed by crosslinking of bioactive ions, which recruit stem cells and enhance skin regeneration.

Graphical abstract: Injectable bioactive akermanite/alginate composite hydrogels for in situ skin tissue engineering
Paper

Phycocyanin-based nanocarrier as a new nanoplatform for efficient overcoming of cancer drug resistance

The rational design of a novel phycocyanin-based nanosystem with bio-responsive properties to achieve prolonged blood circulation and overcome drug resistance without causing systemic toxicity.

Graphical abstract: Phycocyanin-based nanocarrier as a new nanoplatform for efficient overcoming of cancer drug resistance
Paper

Hybrid inhalable microparticles for dual controlled release of levofloxacin and DNase: physicochemical characterization and in vivo targeted delivery to the lungs

Current medical treatments against recurrent pulmonary infections caused by Pseudomonas aeruginosa, such as cystic fibrosis (CF) disorder, involve the administration of inhalable antibiotics.

Graphical abstract: Hybrid inhalable microparticles for dual controlled release of levofloxacin and DNase: physicochemical characterization and in vivo targeted delivery to the lungs
Paper

A biophysical study of gene nanocarriers formed by anionic/zwitterionic mixed lipids and pillar[5]arene polycationic macrocycles

A multivalent cationic macrocycle is used as a mediator between plasmid DNAs and anionic lipids (ALs) to build an efficient and safe gene nanocarrier.

Graphical abstract: A biophysical study of gene nanocarriers formed by anionic/zwitterionic mixed lipids and pillar[5]arene polycationic macrocycles
Paper

A two-photon fluorescent probe for viscosity imaging in vivo

A quinoline-based two-photon fluorescent probe (MCN) was developed for viscosity imaging in vivo.

Graphical abstract: A two-photon fluorescent probe for viscosity imaging in vivo
Paper

808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures

A dual-drug co-delivery and 808 nm NIR photo-controlled release system can control drug release behaviour and enhance anticancer efficacy.

Graphical abstract: 808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures
Paper

A patterned nanocomposite membrane for high-efficiency healing of diabetic wound

A bioactive glass/patterned electrospun membrane (BG/PEM) with uniform nanostructure could stimulate angiogenesis and accelerate diabetic wound healing with high efficiency.

Graphical abstract: A patterned nanocomposite membrane for high-efficiency healing of diabetic wound
Paper

Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells

Here, polystyrene sulfonate sodium (PSS) modified halloysite nanotubes were self-assembled into patterned coating on a glass substrate with ordered nanotube arrays for capture of tumor cells.

Graphical abstract: Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells
Paper

The hypothermic preservation of mammalian cells with assembling extracellular-matrix-mimetic microparticles

The reversible assembly of magnetic alginate microparticles could mimic the extracellular matrix for efficient and facile hypothermic cell preservation.

Graphical abstract: The hypothermic preservation of mammalian cells with assembling extracellular-matrix-mimetic microparticles
Paper

A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo

Polyethylenimine can be modified with folic acid through a polyethylene glycol spacer for targeted anticancer drug delivery to tumors.

Graphical abstract: A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo
Paper

Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells

Sub-10 nm Au NPs with an average size of 4 nm (Au4-mPEG NPs) had a promotive effect on the adipogenic differentiation and an inhibitive effect on the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) due to the highly induced ROS level.

Graphical abstract: Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells
Paper

Sonochemically-fabricated Ga@C-dots@Ga nanoparticle-aided neural growth

In this paper, we report the fabrication of an antibacterial material, Ga-doped C-dots on Ga nanoparticles (Ga@C-dots@Ga NPs), which is deposited on a glass substrate for neural growth.

Graphical abstract: Sonochemically-fabricated Ga@C-dots@Ga nanoparticle-aided neural growth
Paper

Glycopolymer monoliths for affinity bioseparation of proteins in a continuous-flow system: glycomonoliths

Macroporous materials, called glycomonoliths, were prepared from saccharide-containing monomers, and applied for affinity bioseparation of proteins in a continuous-flow system.

Graphical abstract: Glycopolymer monoliths for affinity bioseparation of proteins in a continuous-flow system: glycomonoliths
Paper

Serum-free culturing of human mesenchymal stem cells with immobilized growth factors

Growth factors were immobilized with photo-reactive gelatin and used for serum-free human mesenchymal stem cell (hMSC) culturing.

Graphical abstract: Serum-free culturing of human mesenchymal stem cells with immobilized growth factors
Paper

Development of ionic strength/pH/enzyme triple-responsive zwitterionic hydrogel of the mixed L-glutamic acid and L-lysine polypeptide for site-specific drug delivery

Environmentally responsive hydrogels for drug delivery.

Graphical abstract: Development of ionic strength/pH/enzyme triple-responsive zwitterionic hydrogel of the mixed l-glutamic acid and l-lysine polypeptide for site-specific drug delivery
Paper

The application of a G-quadruplex based assay with an iridium(III) complex to arsenic ion detection and its utilization in a microfluidic chip

In this work, the iridium(III) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution.

Graphical abstract: The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip
Paper

Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications

A new type of epigallocatechin gallate based magnetic core–shell nanoplatform for cancer theranostic applications.

Graphical abstract: Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications
Paper

1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications

Minimal AIEEgens containing only a single ring were synthesized through a facile biocatalysis procedure and were successfully utilized in the imaging of mitochondria.

Graphical abstract: 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications
Paper

A reusable supramolecular platform for the specific capture and release of proteins and bacteria

A re-usable supramolecular platform with the capability of high-efficiency capture and on-demand release of specific proteins and bacteria was developed.

Graphical abstract: A reusable supramolecular platform for the specific capture and release of proteins and bacteria
Paper

Cholyl-L-lysine-carboxylbutyryl adriamycin prodrugs targeting chemically induced liver injury

A liver-targeting nano-delivery system to protect liver from chemical injury was presented.

Graphical abstract: Cholyl-l-lysine-carboxylbutyryl adriamycin prodrugs targeting chemically induced liver injury
Paper

Composite scaffolds of gelatin and gold nanoparticles with tunable size and shape for photothermal cancer therapy

Composite porous scaffolds of gelatin and gold nanoparticles with tunable size and shape are prepared for the photothermal ablation of cancer cells. The cell killing efficiency of the composite scaffolds is highly dependent on the shape and size of AuNPs.

Graphical abstract: Composite scaffolds of gelatin and gold nanoparticles with tunable size and shape for photothermal cancer therapy
Paper

Enhanced green fluorescence protein/layered double hydroxide composite ultrathin films: bio-hybrid assembly and potential application as a fluorescent biosensor

This article reports the fabrication and application of enhanced green fluorescent protein/layered double hydroxide nanosheet (EGFP/LDH)n ultrathin films via layer-by-layer assembly technique based on electrostatic and hydrogen-bond interactions.

Graphical abstract: Enhanced green fluorescence protein/layered double hydroxide composite ultrathin films: bio-hybrid assembly and potential application as a fluorescent biosensor
59 articles

About this collection

This on-going web collection features all the articles published inJournal of Materials Chemistry B in 2017 marked as HOT, as recommended by referees.  Congratulations to all the authors whose articles are featured!

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