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A porous sodium polyacrylate-grafted chitosan xerogel for severe hemorrhage control made from one-pot reaction

Abstract

Control of severe hemorrhage remains a challenge. Successful hemorrhage control depends on the speed and quality of blood clot formation. Fast deprivation of water from blood leads to the concentration of blood cells and coagulation factors and thus triggers blood clot formation. This inspired us to develop a new hemostatic material. In this study, we grafted sodium polyacrylate (SPA) onto the backbone of chitosan (CTS) and cross-linked with methacrylic anhydride–modified polyethylene glycol (MAAPEG) to provide flexible and elastic inter-chain connection between SPA and CTS chains in the presence of a blowing agent to achieve a porous structure. By a simple one-pot-reaction, we fabricated a soft, elastic porous xerogel sponge which could reach maximum water absorbency of 180 in less than 200 seconds. This SPA-co-Chitosan xerogel sponge demonstrated superior hemostatic effect in thromboelastography (TEG®) test and in a rabbit lethal extremity arterial bleeding model in comparison with zeolite granules, kaolin gauze and chitosan granules. Furthermore, this hemostat worked as a whole to transfer external pressure to the bleeding area and was adhesive to wet wound tissue to seal the bleeding site. In general, the SPA-co-CTS sponge demonstrated a fast and powerful hemostatic effect both in vitro and in vivo, which was superior over existing commercial products. It might be a promising first-aid device for severe hemorrhage control.

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Publication details

The article was received on 23 Mar 2017, accepted on 10 May 2017 and first published on 11 May 2017


Article type: Paper
DOI: 10.1039/C7TB00802C
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    A porous sodium polyacrylate-grafted chitosan xerogel for severe hemorrhage control made from one-pot reaction

    Z. Qian, H. Wang, X. Tuo, H. Guo, P. Xu, D. Liu, Y. Wei, X. Guo, Y. Fan and H. Liu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00802C

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