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Reduced glutathione-activated antioxidant defence breaking for enhanced photodynamic therapy

Abstract

Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cancer cells. However, a high concentration of reduced glutathione (GSH) is present in cancer cells and can consume ROSs and sharply reduce PDT activity. To address this problem, herein, we synthesized a thymine modified Zn phthalocyanine (ZnPc, monomer and active form for PDT) and prepared its nanoparticle form (aggregator and inactive form) with Hg2+ driving for “thymine-Hg2+-thymine” interaction. The nanoparticles could maintain inactive form during deliver process in blood. Once endocytosed by cancer cells, the nanosparticle is disintegrated, the Hg2+ was deprived by intracellular GSH to decrease the level of GSH. Simultaneously, the activity of released monomer ZnPc was recovered and show high PDT activity.

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Publication details

The article was received on 06 May 2017, accepted on 12 Jul 2017 and first published on 15 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01233K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Reduced glutathione-activated antioxidant defence breaking for enhanced photodynamic therapy

    Q. Zhan, X. Shi, X. Yan, Q. Liu, J. zhou, L. Zhou and S. Wei, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01233K

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