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Dendritic Catiomer with MOF Motif for Construction of Safe and Efficient Gene Delivery Systems

Abstract

Ethanolamine (EA) functionalized poly (glycidyl methacrylate) (PGMA-EA) have been validated by our pioneering researches as the promising materials for manufacture of gene delivery systems. Here, PGMA-EA was schemed to attach at the terminus of the MOF ligands for construction of nanoscaled dendritic catiomer. The resulting molecular structure was arranged to possess well-defined flanking secondary amine and hydroxyl groups, which consequently exerted drastic potency in DNA condensation (approximate 100 nm) and provided appreciable colloidal stabilities in the biological milieu. Of note, as compared to the commercial ‘gold standard’ of branched PEI (25 kDa), the proposed catiomer exhibited markedly higher transfection efficiency by virtue of the appreciable cationic dendritic structure and lower cytotoxicity by virtue of rationale arrangement of hydroxyl groups. Therefore, the present work encouraged the utility of MOF-motif in engineering spatial functional and biological functional nanoscaled structure for biomedical applications.

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Publication details

The article was received on 21 Jul 2017, accepted on 29 Sep 2017 and first published on 02 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01966A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Dendritic Catiomer with MOF Motif for Construction of Safe and Efficient Gene Delivery Systems

    S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma and H. Gao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01966A

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