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Influence of microporous gelatin hydrogels on chondrocyte functions

Abstract

Hydrogels can provide biomimetic three-dimensional microenvironments for transplanted cells and are attractive scaffolds for cartilage tissue engineering. In this study, gelatin hydrogels with microporous structures were prepared and their effects on chondrocyte functions were compared with gelatin hydrogels without microporous structures. Gelatin bulk hydrogels were prepared by photo-initiated crosslinking of gelatin methacrylate macromers. Micropores were formed in the bulk hydrogels by dissolution of gelatin microgels prepared by a cutting method. Chondrocytes cultured in gelatin hydrogels without microporous structures showed high expression and production of cartilaginous matrices while low cell proliferation. Chondrocytes cultured in gelatin hydrogels with microporous structures tended to migrate from bulk hydrogel matrices to the micropores. Chondrocytes in the microporous hydrogels showed higher proliferation while lower expression and production of cartilaginous matrices than did the chondrocytes cultured in hydrogels without microporous structures. Gelatin hydrogels without microporous structures facilitated maintenance of cartilaginous phenotype of chondrocytes while microporous gelatin hydrogels were beneficial for cell proliferation.

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Publication details

The article was received on 17 May 2017, accepted on 13 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01350G
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Influence of microporous gelatin hydrogels on chondrocyte functions

    X. Li, Y. Chen, N. Kawazoe and G. Chen, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01350G

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