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Multifunctional Cu39S28 Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy

Abstract

Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, multifunctional active tumor targeting nanoplatform were establised. First, unique Cu39S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (99.5 %). At the same time, the drug carrier have shown great sensitive response of release to either pH value or near infrared ray (NIR). In particular, the folic acid (FA) can easily conjugate with the synthesized Cu39S28 HNPs without further modification to get a targeted effect. The FA modified Cu39S28 HNPs showed an efficiently targeting effect in vitro and could considerably enhance the tumor-targeting effect more than 10 times in vivo. On this basis, the synthetical hyperthermia and targeted drug release could significantly improve the therapeutic efficacy compared with photothermal or chemotherapy alone both in vitro and in vivo. The histological studies in main organs futher proved the well biocompatibility and tumor ablation effect, the tumor sites were vague and in seriously destruction due to the synthetic therapy effect. Therefore, the HNPs can be developed as promising antitumor agents for their superb PTT, drug loading efficiency and cancer therapy effect in breast cancer.

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Publication details

The article was received on 20 Apr 2017, accepted on 03 Jun 2017 and first published on 08 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01086A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Multifunctional Cu39S28 Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy

    L. Li, X. Yang, X. Hu, Y. Lu, L. Wang, M. Peng, H. Xia, Q. Yin, Y. Zhang and G. han, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01086A

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