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Development of a dual drugs loaded hydrogel delivery system for enhanced cancer therapy: in situ forming, degradation and synergistic antitumor efficiency

Abstract

The dual drugs loaded hydrogel delivery system was constructed with aldehyded pullulan (A-Pul), ε-poly-L-lysine (ε-PL), branched polyethyleneimine (BPEI) in aqueous solution by Schiff base reaction. CDDP and DOX were loaded into the network of the hydrogels for combination drug therapy. The gelation time was changed from 40 s to 240 s when the reaction solutions were stored at different temperature. Scanning electronic microscopy images and swelling dynamics exhibited the hydrogels had homogeneous porous structure and good swelling behavior. The in vitro degradation rate and drugs release rate at pH 7.0 were faster than pH 7.4 indicating the hydrogels had a controlled drug release and pH-dependent behavior. The hydrogels could be injected and in situ formed and degraded in vivo, and the dual drugs loaded hydrogel displayed the most efficient tumor inhibition, which indicating the synergistic anticancer effect of the CDDP+DOX combination therapy in H22 liver tumor bearing mice. Furthermore, the hydrogels had no cytotoxicity on Huh-7 cells and exhibited excellent security and biocompatibility in vivo. Therefore, the hydrogels have potential application in multi-drug carrier for enhanced synergistic therapy. Key words: hydrogels; in situ formation; pH-dependent; synergistic therapy; antitumor efficiency

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Publication details

The article was received on 14 Aug 2017, accepted on 06 Oct 2017 and first published on 08 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02173A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Development of a dual drugs loaded hydrogel delivery system for enhanced cancer therapy: in situ forming, degradation and synergistic antitumor efficiency

    C. Cheng, X. Zhang, Y. Meng, L. Chen and Q. Zhang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02173A

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