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In vitro degradation behavior of hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair

Abstract

A poly(glycolide) (PGA) fiber-reinforced hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) composite with high mechanical strength has been prepared previously. In this paper, in vitro degradation of the ternary composites with different contents of PGA fibers (0, 30, 50 and 70 wt.%) was investigated. The water absorption showed a marked increase as the degradation was progressed, and the composite with 70 wt.% PGA fibers showed the highest final water uptake which was 3.89 times higher than the initial value. The mass loss of the composite with 70 wt.% PGA fibers was 79.3 ± 6.47% at 16 weeks, which was the greatest in all the composites. The molecular weight of PLGA matrix decreased over time especially for the composites containing 70 wt.% PGA fibers. The lowest pH of buffer solution was also observed in the composite with 70 wt.% PGA fibers. Environmental scanning electron microscope (ESEM) and micro-computed tomography (micro-CT) results demonstrated that the porosity of the composites and the size of pores gradually increased as the degradation was progressed. The most significant change in compression strength was observed for the composite with 70 wt.% PGA fibers which was reduced from an initial value of 20 MPa to approximate 1 MPa at 16 weeks. The results indicated that the in vitro degradation of the composites could be accelerated by increasing content of PGA fibers. It implied that the ternary composites might be a candidate for the repair of non-load bearing or cancellous bone which needs high initial strength and fast degradation rate.

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Publication details

The article was received on 04 Sep 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02364B
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    In vitro degradation behavior of hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair

    Y. Zhu, Z. Wang, L. Li, D. Gao, Q. Xu, Q. Zhu and P. Zhang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02364B

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