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Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

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Abstract

The energy transfer from upconversion nanoparticles (UCNPs) to photosensitizers has been widely used for generating reactive oxygen species (ROS) in photodynamic therapy (PDT) by near infrared (NIR) excitation. However, the poor spectral overlap of lanthanide ions and conventional photosensitizers leads to low PDT efficiency. In this study, we construct a multilayered upconversion nanoplatform with dual photosensitizers to efficiently use the UV and visible upconversion emissions in NIR-responsive PDT. The nanoplatform consists of three functional layers, which are the upconversion nanoparticle as a core, and light-sensitive conjugated polymer and apo-transferrin-titanocene (Tf@Tc) as shells. Under NIR irradiation, apparent energy transfer occurs from the core to the polymer and Tc components in the shell, producing reactive oxygen species and free radicals for cancer cell killing. In vitro cellular assays show the synergistic therapeutic effect of the conjugated polymer and Tc as photosensitizers. In vivo animal studies show that tumor growth is significantly inhibited in the mice receiving the theranostic platform and NIR irradiation. Based on these observations, the multilayered upconversion nanocomposites can find potential applications in NIR-mediated anti-tumor therapy.

Graphical abstract: Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

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Publication details

The article was received on 21 Jul 2017, accepted on 21 Sep 2017 and first published on 25 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01968H
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

    S. Liu, Y. Yuan, Y. Yang, Z. Liu, S. Yin, W. Qin and C. Wu, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB01968H

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