Themed collection 2020 RSC Advances HOT Article Collection

In recent years, some natural products isolated from the fungus of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti-hyperglycemic and anti-hyperlipidemic effects.

This review highlights the various photo diagnostic and treatment methods utilized for CRC, over the last seven years.

α,β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of potential anticancer agents.

The combination of naringenin–cis-platin prevents the invasion of cancer, at a lower concentration of cis-platin.

Several recent ML algorithms for de novo molecule generation have been utilized to create an open-access database of virtual molecules.

A series of novel 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives were synthesized and their in vitro inhibitory potencies were evaluated on MERS-S pseudovirus.

In silico exploration of 12 Tecoma phytocompounds that could serve as potential inhibitors of SARS-CoV entry to host cells.

Dihydrofolate reductase (DHFR) inhibitors, as antibacterial agents, contain pyrimidine, pteridine, and azine moieties among many other scaffolds.

The general method for the preparation of DHPM analogs; cytotoxic activity and binding mode of the most active derivative against PI3Kγ and CDK2 targets.

Non-traditional hydrogen bonds between a singlet carbene and a series of ditopic secondary amines is detailed. Both the solid- and solution-state metrics reveal the strength of these associations are dependent on the pK_a of the NH-containing molecule.

Copper metaborate had a unique crystal structure and exhibited noteworthy magnetic phase transitions at 21 and 10 K.

New computational protocol applied to a repurposing campaign against SARS-CoV-2.

Chemical vapor modification simultaneously improved the membrane wetting resistance and permeate flux for membrane distillation. The modification enabled desalination using membranes with pore size > 1 μm and demonstrated significant flux enhancement.

A family of 7-aryl-3-methylpyrazolo[1,5-a]pyrimidines have been identified as strategic compounds for optical applications by a comprehensive theoretical-experimental study.

Seeds composition is crucial for the mechanism of seeding and therefore morphological, textural and catalytic properties of BEA zeolites.

Catalytically inactive cellulose nanofibers with crystalline solid surfaces enhance highly enantioselective organocatalysis at the interface in proline-mediated aldol reactions.

Active ingredient screening and target prediction techniques were used to determine the components of Cyclocarya paliurus responsible for its anti-diabetic effects as well as their targets.

Deep eutectic solvent in water emulsions stabilised with bio-macromolecules were stable for more than 200 days.

Evaporation-driven colloidal assembly of silicalite-1 nanoparticles into well-defined micro-sized spheres at low temperature and preparation times.

COVID-19 has been declared as a global health emergency and exposed the world to a deadly virus, which has dramatically changed the lives of humans for an unknown period of time.

Novel trifluoromethylpyridine amide derivatives containing sulfur moieties were synthesized, which exhibited good antibacterial and insecticidal activities for potential crop protection agents.

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 M^pro than chloroquine/cinanserin along with lower toxicity.

Separated P-diastereomers of 3′-N-(2-thio-1,3,2-oxathiaphospholane) derivatives of 5′-O-DMT-3′-amino-2′,3′-dideoxy-ribonucleosides were used to prepare P-stereodefined N_NPSN′ dinucleotides and short NPS-, NPS/PO- and NPS/PS-oligomers.

This study provided a new mechanistic understanding of humin formation during 5-HMF production from hexose in ionic liquids.

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Reaction between NiFe LDH and NaBH₄ induces vacancies around Fe³⁺ and enrichment in Ni³⁺, crucially activating the OER catalyst leading to high performance.

A facile one-pot synthesis has been developed through alkylation/acylation of ortho-tosylaminophenyl-substituted para-quinone methides followed by an intramolecular 1,6-conjugate addition and oxidation sequence.

Primer extension by T7 RNA polymerase showed preference of monomer through base stacking beyond Watson–Crick rules under molecular crowding condition.

Homology modeling, docking, pharmacophore based VS and molecular dynamics identified potential hits against P. aeruginosa specific LpxK.

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

In this work, we demonstrated a facile supramolecular approach based on modularly designed multi-domain peptides to construct peptide-based nanomaterials with intrinsic cell penetrating activity and excellent cytocompatibility.

An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields respectively (up to 94% yield).

The reaction employing H₂O and O₂ as the co-oxygen source in the catalytic synthesis of α-ketoamides is described. This Cu-catalyzed reaction is carried out in a tandem manner constituted by hydroamination of alkyne, hydration of vinyl–Cu complex and subsequent oxidation.

The preparation method of cationic proteoliposomes is established using a cell-free membrane protein synthesis in the presence of cationic liposomes.

Yttrium and europium are selectively recovered from spent fluorescent lamps using levulinic acid-based solvents.

Since the outbreak of Coronavirus disease (COVID-19) caused by SARS-CoV-2 in December 2019, there has been no vaccine or specific antiviral medication for treatment of the infection where supportive care and prevention of complications is the current management strategy.

In the present study, the structural characteristics and antioxidant activities of polysaccharide from the co-cultured Lepista sordida and Pholiota nameko and its polysaccharide-iron(III) chelates were determined.

Nanopore detection of single-molecule G-quadruplexes.

Conformational changes in the remdesivir-bound RdRP leading to its inhibition.

Two new HSA-involved tetra(butylamino)phthalocyanine composite nanoparticles, as highly efficient dual-phototherapy agents upon a single NIR laser irradiation, were reported.

An efficient synthesis of xanthene/thioxanthene-indole derivatives has been developed through iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ols and thioxanthen-9-ol with indoles.

As part of a global effort to identify drug candidates for the treatment of COVID-19, herein, we report small molecules commercially available selected from a consensus virtual screening strategy.

A one-pot method for β-amino alcohol synthesis based on α-hydroxylation and subsequent amide or nitrile functional group reduction has been identified and examined.

The study presents the influence of structure modulation by introduction of selected donor and acceptor substituents on the properties of 6-(1H-bezimidazole)-2(2,4-dinitrobenzenesulfonate)naphthalene used in thiophenol identification.

Applicability of Raman spectroscopy for time-resolved gas composition monitoring during direct methanol synthesis via carbon dioxide hydrogenation is investigated.

A monomeric complex of Zn^II with ornidazole [Zn(Onz)₂Cl₂] decreases formation of the nitro-radical anion (R–NO₂˙⁻), and this is realized by recording it in an enzyme assay using xanthine oxidase, which is a model nitro-reductase.

Three candicates gained by a novel artificial intelligence protocol for Parkinson's disease (PD).

A flexible temperature sensor is developed by directly writing or mask spraying commonly-used paper with graphene nanoribbon ink. The sensor is ultralow cost, degradable, and highly promising as a disposable device for personal healthcare.

Here, environmental dust cleaning from an inclined hydrophobic surface by rolling liquid droplets has been studied and the influence of fluid droplets on the dust removal rate has been examined.

A new, inexpensive and easy to use 3D printable device was developed for nephelometric and fluorimetric determination.

Aerobic oxidation of native soft wood lignin in an aqueous solution of Bu₄NOH facilitates efficient production of vanillin (4-hydroxy-3-methoxybenzaldehyde), which is one of the platform chemicals in industry.

Accurate and efficient screening of retired lithium-ion batteries from electric vehicles is crucial to guarantee reliable secondary applications such as in energy storage, electric bicycles, and smart grids.

We modified fluoxetine by incorporating a selenium nucleus enabling a hydroperoxide-inactivating, glutathione peroxidase (GPx)-like activity and paving the way for its use as green catalyst.

Based on the optical quenching phenomenon, a smart mesoporous phosphorescent microsensor was built.

Intensive insight into the potential mechanisms of Se-induced Cd tolerance in cucumber seedlings is essential for further improvement of vegetable crop cultivation and breeding to obtain high yields and quality in Cd-contaminated soil.

The quinone group protonation state determines the reaction mechanism of noradrenaline and adrenaline o-quinone cyclization.

Neuronal cells exposed to H₂O₂ may undergo increase ROS, reduction in cell viability and cell death. Butein, isoliquiritigenin, and scopoletin ameliorated H₂O₂-induced neurotoxicity by reducing ROS, balancing antioxidants and activating SIRT1-FoxO3a-ADAM10 pathway.

The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen Helicobacter pylori (H. pylori), conferring acid resistance to the bacterium.

Photosystem I-biophotovoltaics based on p-type dye-sensitized solar cells and a tandem cell was demonstrated.

A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery.

A HER2-binding protein, HBP-FLAP, developed by peptide immobilization specifically binds to HER2 and has improved resistance to proteases.

A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported.

Ultrathin NiFe-LDH nanosheets with sulfate interlayer anions prepared in gram-scale via one-pot solvothermal method exhibited excellent OER activity.

Di-mannosylated peptides reveal mannose binding to cyanovirin-N (CV-N) low-affinity binding sites.

The stronger adsorption of 8-MQL hampers further adsorption of 4H-8-MQL, which results in the difficulty in 10H-8-MQL production.

First study demonstrating the use of physically engineered magnetic particles that display two functionalities for cancer treatment.

Four new 3,4-dihydroisocoumarin congeners, named lophiostomin A–D (1–4), together with two known α-pyridones (5 and 6) were isolated from cultures of the endophytic fungus Lophiostoma sp. Sigrf10 obtained from Siraitia grosvenorii.

A strain with strong antifungal activity, Bacillus subtilis NS-174, was identified and the antifungal compounds were purified and structurally analyzed by high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS).

Ethanol addition to diesel fuels significantly affects the leaching potentials of petroleum hydrocarbons, thereby making them inaccessible to rhizoremediation.

A novel and promising Schiff base and Ce(III)-complex were synthesized and fully characterized. A novel creatinine optical biosensor based on Ce(III)-complex and could be a promising analytical tool and as a promising kidney biomarker.