Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy
The strategies and obstacles for overcoming the barriers in the tumor microenvironment are presented.
Harnessing biomolecules for bioinspired dental biomaterials
We review the range of biomolecules used across dental biomaterials to spur the design and implementation of bioinspired multifunctional materials.
Recent advances of near infrared inorganic fluorescent probes for biomedical applications
Near infrared (NIR)-excitable and NIR-emitting probes have fuelled advances in biomedical applications owing to their power in enabling deep tissue imaging, offering high image contrast and reducing phototoxicity.
Advances and challenges in metallic nanomaterial synthesis and antibacterial applications
Schematic diagram of the antibacterial mechanism of metal nanoparticles.
Stretchable and tough conductive hydrogels for flexible pressure and strain sensors
This review summarises recent advances in stretchable and tough conductive hydrogel sensors for wearable and implantable devices.
From design to applications of stimuli-responsive hydrogel strain sensors
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both hydrogel and smart functional materials have attracted increasing interest from material design to emerging applications in health monitors and human–machine interfaces.
Materials and technical innovations in 3D printing in biomedical applications
This review highlights the recent advancements of new materials and 3D printing techniques developed to address the unfulfilled needs of the conventional 3D printing methodologies in biomedical applications.
2D nanostructures beyond graphene: preparation, biocompatibility and biodegradation behaviors
The research advances of the preparation, biocompatibility and biodegradation of 2D nanomaterials are introduced. The prospects and challenges of the biomedical applications of 2D nanomaterials are summarized.
Gold nanoclusters for biomedical applications: toward in vivo studies
In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties.
Substituted hydroxyapatite coatings of bone implants
This review is a comprehensive overview and analysis of the most important advances in the field of substituted hydroxyapatite coatings.
Dendrimer nanoparticles for colorectal cancer applications
Routes of dendrimer synthesis and the stages of possible applicability of dendrimer nanoparticles in the case of colorectal cancer.
Beyond Fmoc: a review of aromatic peptide capping groups
Self-assembling short peptides have widespread applications in energy materials, tissue engineering, sensing and drug delivery. In this review we discuss the effect of functional N-terminal capping groups on peptide structure and function.
Thermoresponsive polymers and their biomedical application in tissue engineering – a review
Thermoresponsive surfaces are used for the fabrication of cell sheets for tissue engineering purposes. Basic processes, necessary for understanding, are described and thermoresponsive polymers and their application in the biomedical field presented.
Effect of molecular weight and polymer composition on gallol-functionalized underwater adhesive
A gallol-functionalized polymer showed strong adhesion ability underwater. The effect of molecular weight and gallol content have been optimized resulting in the underwater adhesion strength as high as 4 MPa.
High-performance non-enzymatic glucose detection: using a conductive Ni-MOF as an electrocatalyst
A glucose sensor based on a conductive Ni-MOF as an electrocatalyst exhibits a fast response time, low detection limit, and high sensitivity, and it can also be applied for the detection of glucose in blood serum samples.
A multi-model, large range and anti-freezing sensor based on a multi-crosslinked poly(vinyl alcohol) hydrogel for human-motion monitoring
A high-mechanical, ionic conductive and anti-freezing multi-crosslinked poly(vinyl alcohol) hydrogel was assembled as a multi-model, large range and wearable sensor.
Innate immune activation by conditioned medium of cancer cells following combined phototherapy with photosensitizer-loaded gold nanorods
Nanoparticle-based phototherapy has evolved to include immunotherapy as an effective treatment combination for cancers through inducing anti-cancer immune activation leading to downstream adaptive responses and immune protection.
Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions
A skin-matched soft strain/pressure sensor fabricated by fully physically crosslinked conductive PDA–rGO/PVA hydrogel is reported for sensitive healthcare monitoring and human-machine interaction.
A benzothiazolium-based fluorescent probe with ideal pKa for mitochondrial pH imaging and cancer cell differentiation
A benzothiazolium-based fluorescent pH probe HTBT2 with an ideal pKa of 8.04 ± 0.02 for imaging mitochondrial pH in living cells.
Multifunctional nanoparticles for targeting the tumor microenvironment to improve synergistic drug combinations and cancer treatment effects
Nanoparticles can internalize into cancer cells through CD44 and P-selectin ligand recognition, leading to significant enhancement of anti-prostate tumor activity.
Controlled radical polymerization of hydrophilic and zwitterionic brush-like polymers from silk fibroin surfaces
Silk fibroin films were modified with zwitterionic and hydrophilic brush-like polymers via surface-initiated ATRP, resulting in surfaces that reduced protein adsorption and cell attachment.
Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery
A facile approach for the highly luminescent and biocompatible CsPbBr3@SiO2 core–shell PNCs was developed. The dual biological roles of these PNCs are demonstrated, offering new directions to the stable PNCs for a variety of biomedical applications.
MOF based flexible, low-cost chemiresistive device as a respiration sensor for sleep apnea diagnosis
A MOF based breath sensor with an excellent response time is reported for the first time for sleep apnea diagnosis.
Bionic intelligent soft actuators: high-strength gradient intelligent hydrogels with diverse controllable deformations and movements
A series of novel nanofibrillated cellulose (NFC) reinforced gradient intelligent hydrogels with high response rate, multiple response patterns and diversified self-driven functions were successfully prepared.
Two-dimensional iron MOF nanosheet as a highly efficient nanozyme for glucose biosensing
A 2D Fe-BTC nanosheet was prepared via a cation exchange route. Its peroxidase-like activity is 2.2 times that of 3D MIL-100(Fe) due to highly accessible surface active sites. This is helpful for substrate contact with the catalyst during the catalytic reaction.
A high-strength double network polydopamine nanocomposite hydrogel for adhesion under seawater
A mussel-inspired catechol-based strategy has been widely used in the development of underwater adhesives.
Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin
A fluorophore–protein complex for the visualization of mitochondria and the mouse intestine was developed. The complex formation of a naphthalene-based dipolar dye and serum albumin was identified and its imaging applications were investigated.
A cerium-based MOFzyme with multi-enzyme-like activity for the disruption and inhibition of fungal recolonization
A cerium-based metal–organic framework (Ce-MOF, denoted as AU-1) was synthesized using a solvothermal method by employing 4,4′,4′′-nitrilotribenzoic acid (H3NTB) as the linker and cerium clusters as the metal center.
14N–1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
14N–1H HMQC experiments are powerful experiments to characterize amorphous drug–polymer formulations of paclitaxel yielding well-separated signals in the 14N dimension as well as information on the symmetry of 14N and 14N–1H interactions.
Phosphate-responsive 2D-metal–organic-framework-nanozymes for colorimetric detection of alkaline phosphatase
Phosphate-responsive peroxidase-mimicking two-dimensional-metal–organic-framework nanozymes were employed to develop alkaline phosphatase assays with tunable dynamic ranges and colorimetric logic gates.
Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro
Hydrolytically stable, phototunable hybrid-hydrogels containing clickable decellularized extracellular matrix enable spatiotemporal control over fibroblast activation.
3D printing of cell-laden electroconductive bioinks for tissue engineering applications
Bioprinting is an emerging powerful fabrication method, which enables the rapid assembly of 3D bioconstructs with dispensing cell-laden bioinks in pre-designed locations.
A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence.
Pyridinium-substituted tetraphenylethylene salt-based photosensitizers by varying counter anions: a highly efficient photodynamic therapy for cancer cell ablation and bacterial inactivation
A highly efficient photodynamic therapy of cancer cell ablation and bacterial inactivation by two AIEgens was reported.
Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage
Drug localisation is one of the main challenges in treating cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; their efficacy depends on the polymer structure hence the full potential of this system is still unknown.
Tuning of endosomal escape and gene expression by functional groups, molecular weight and transfection medium: a structure–activity relationship study
A library of cationic polyacrylamide homopolymers was synthesized and their gene delivery, endosomal release, and interaction with endosome-specific lipids were investigated. The guanidinium-containing polymers were most efficient.
A bioinspired hydrogen bond crosslink strategy toward toughening ultrastrong and multifunctional nanocomposite hydrogels
A bioinspired hydrogen bond crosslink strategy enabled the physical hydrogels to possess exceptional mechanical properties, good self-recoverability, versatile adhesiveness, biocompatibility and antibacterial properties.
Tuning the strength and swelling of an injectable polysaccharide hydrogel and the subsequent release of a broad spectrum bacteriocin, nisin A
Balance of glycol chitosan content and crosslink density modulates injectable gel swelling, strength and the release of an antimicrobial peptide.
Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics
Composite material enabling the delivery of synergistic combination of doxorubicin and gemcitabine against breast cancer with molar and kinetic precision.
Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring
A stretchable gold fiber-based wearable electrochemical pH two-electrodes sensing system for human health monitoring.
Functionalized tungsten disulfide nanotubes for dopamine and catechol detection in a tyrosinase-based amperometric biosensor design
Functionalized tungsten disulfide nanotubes were evaluated as an enzyme support for electrochemical biosensors.
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer
A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.
Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy
Carbon-based nanomaterials (CNMs) have attracted great attention in biomedical applications such as cancer imaging and therapy.
Synthesis, characterization and investigation of synergistic antibacterial activity and cell viability of silver–sulfur doped graphene quantum dot (Ag@S-GQDs) nanocomposites
In this work, a new nanocomposite (Ag@S-GQDs) have been synthesized using one-step facile synthesis process and their antibacterial as well as cytotoxicity properties were investigated systematically.
Efficient co-delivery of microRNA 21 inhibitor and doxorubicin to cancer cells using core–shell tecto dendrimers formed via supramolecular host–guest assembly
Core–shell tecto dendrimers formed via supramolecular assembly enable co-delivery of microRNA 21 inhibitor and doxorubicin for enhanced anticancer therapy applications.
A distinctive mitochondrion-targeting, in situ-activatable near-infrared fluorescent probe for visualizing sulfur dioxide derivatives and their fluctuations in vivo
A mitochondria-targeting and in situ-activatable near-infrared fluorescent probe has been developed for imaging sulfur dioxide derivatives and their fluctuations in vivo.
Ratiometric fluorescent probes based on through-bond energy transfer of cyanine donors to near-infrared hemicyanine acceptors for mitochondrial pH detection and monitoring of mitophagy
Two ratiometric near-infrared fluorescent probes (A and B) have been developed to selectively and accurately detect mitochondrial pH changes based on highly efficient through-bond energy transfer (TBET) from cyanine donors to near-infrared-emissive hemicyanine acceptors.
Effect of boron incorporation on the bioactivity, structure, and mechanical properties of ordered mesoporous bioactive glasses
B2O3 doped (0.5–15 mol%) ordered mesoporous bioactive glasses were synthesized via sol–gel based evaporation-induced self-assembly using P123 as a structure directing agent and characterized by biokinetic, mechanical and structural investigations.
A self-healable and antifouling hydrogel based on PDMS centered ABA tri-block copolymer polymersomes: a potential material for therapeutic contact lenses
We have prepared an antifouling and self-healable PDMS based hydrogel which consists of a mixture of curcumin loaded zwitterionic PDMS polymersomes and amine functionalized PDMS polymersomes prepared via RAFT polymerization and Schiff-base reaction.
About this collection
This web collection features the top 50 most popular articles published in Journal of Materials Chemistry B in 2020.
Congratulations to all of the authors whose articles have been featured!