Issue 33, 2020

A cerium-based MOFzyme with multi-enzyme-like activity for the disruption and inhibition of fungal recolonization

Abstract

A cerium-based metal–organic framework (Ce-MOF, denoted as AU-1) was synthesized using a solvothermal method by employing 4,4′,4′′-nitrilotribenzoic acid (H3NTB) as the linker and cerium clusters as the metal center. The material was considered as a MOFzyme based on the peroxidase-like activity of Ce-MOF that could eliminate and kill fungi, such as Aspergillus flavus, Aspergillus niger, Aspergillus terreus, Candida albicans, and Rhodotorula glutinis. Ce-MOF showed high antifungal activity against airborne opportunistic human pathogens isolated from the outside of a hospital. The antifungal activity of CeMOF was evaluated using the colony-forming units, dry mass method, soluble proteins, and microscopic imaging. It exhibited an inhibition efficiency of 93.3–99.3% based on the colony-forming unit method. The Ce-MOF caused extensive deformation of the conidiophores, vesicles, and phialides with growth inhibition between 7.55–77.41% (based on the dry mass method). Ce-MOF showed different efficiencies in inhibiting the different fungal species. The biological activity of Ce-MOF was due to its enzymatic activity, such as those of antioxidants, catalase, superoxide dismutase, and peroxidase. Ce-MOF exhibited excellent enzymatic activity towards the fungal cells. Our results may facilitate the design of a MOFzyme system and pave the way for more profound applications of nanozymes.

Graphical abstract: A cerium-based MOFzyme with multi-enzyme-like activity for the disruption and inhibition of fungal recolonization

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
04 Apr 2020
Accepted
16 Jun 2020
First published
27 Jul 2020

J. Mater. Chem. B, 2020,8, 7548-7556

A cerium-based MOFzyme with multi-enzyme-like activity for the disruption and inhibition of fungal recolonization

H. N. Abdelhamid, G. A. Mahmoud and W. Sharmouk, J. Mater. Chem. B, 2020, 8, 7548 DOI: 10.1039/D0TB00894J

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