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Dendrimer nanoparticles for colorectal cancer applications

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Abstract

Cancer nanotechnology is a prolific field of research, where nanotools are employed to diagnose and treat cancer with unprecedented precision. Targeted drug delivery is fundamental for more efficient cancer treatments. For this, nanoparticles have been extensively used during the past few years in order to improve the specificity, selectivity and controlled release of drug delivery. It holds potential in minimizing systemic toxicity through the development of functionalized particles for targeted treatment. Among all the type of nanoparticles, dendrimers display several advantages, which make them ideal candidates for improved and targeted drug delivery in cancer research. Dendrimers can transport large amounts of drug into specific areas. In addition, they can be employed for monitoring the progress of the treatment process, with an unprecedented theranostic capability. Special emphasis is given to colorectal cancer and to the preferred employed strategies for producing drug-loaded/functionalized NPs for cancer therapy in the past few years.

Graphical abstract: Dendrimer nanoparticles for colorectal cancer applications

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Article information


Submitted
16 Oct 2019
Accepted
09 Jan 2020
First published
14 Jan 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Dendrimer nanoparticles for colorectal cancer applications

M. R. Carvalho, R. L. Reis and J. M. Oliveira, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02289A

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