Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery

Author affiliations

Abstract

The encapsulation of lead halide perovskite nanocrystals (PNCs) with an inert protective layer against moisture and the environment is a promising approach to overcome hinderances for their practical use in optoelectronic and biomedical applications. Herein, a facile method for synthesizing highly luminescent and biocompatible CsPbBr3@SiO2 core–shell PNCs with a controlled SiO2 thickness, which are suitable for both cell imaging and drug delivery, is reported. The synthesized CsPbBr3@SiO2 core–shell PNCs exhibit bright green emission at 518 nm upon excitation of 374 nm. Interestingly, a significant increase in the photoluminescence intensity is observed with an increase in the SiO2 shell thickness, which varies with the increasing reaction time. Cytotoxicity results indicate that the CsPbBr3@SiO2 core–shell PNCs are nontoxic, making them suitable for in vitro cell imaging using HeLa cells. Furthermore, doxorubicin physically adsorbed on the surface of CsPbBr3@SiO2 core–shell PNCs is efficiently released in cells when the drug-loaded perovskite nanoprobes are injected in the cells, indicating that these core–shell nanoparticles can be used for drug loading and delivery. The results of this study suggest that the CsPbBr3@SiO2 core–shell PNCs can pave the way for new biomedical applications and processes.

Graphical abstract: Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery

Back to tab navigation

Supplementary files

Article information


Submitted
28 Jul 2020
Accepted
28 Sep 2020
First published
01 Oct 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery

P. Kumar, M. Patel, C. Park, H. Han, B. Jeong, H. Kang, R. Patel, W. Koh and C. Park, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB01833C

Social activity

Search articles by author

Spotlight

Advertisements