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Themed collection 2018 Chemical Science HOT Article Collection

140 items - Showing page 1 of 2
Open Access Edge Article

A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation

An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease.

Graphical abstract: A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Lytic reactions of drugs with lipid membranes

The involvement of drugs in direct chemical reactions with lipids may be linked to toxic effects in liver cell lines.

Graphical abstract: Lytic reactions of drugs with lipid membranes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe

In this work, a novel NIR two-photon fluorescence probe DCM-APN is reported for tracking APN in vitro and in vivo.

Graphical abstract: In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Rare “Janus”-faced Image ID:c8sc04384a-t1.gif single-molecule magnet exhibiting intramolecular ferromagnetic interactions

The unusual ferromagnetically coupled Image ID:c8sc04384a-t2.gif compound was prepared by the use of Me3SiN3 with the metal ions being exclusively bridged by end-on N3. Th cationic molecule is a rare example of a 3d-metal cluster exhibiting a “Janus”-faced SMM behavior for the dried and wet forms.

Graphical abstract: Rare “Janus”-faced single-molecule magnet exhibiting intramolecular ferromagnetic interactions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster

Highly efficient synthesis of biomimetic peptoid sequences enables the rapid design and optimization of chelating ligands for multimetallic clusters.

Graphical abstract: A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Carbon-supported Ni nanoparticles for efficient CO2 electroreduction

Carbon-coated Ni nanoparticles supported on N-doped carbon enable efficient electroreduction of CO2 to CO comparable to single Ni sites.

Graphical abstract: Carbon-supported Ni nanoparticles for efficient CO2 electroreduction
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Antimicrobial peptide based magnetic recognition elements and Au@Ag-GO SERS tags with stable internal standards: a three in one biosensor for isolation, discrimination and killing of multiple bacteria in whole blood

A SERS based biosensor has been developed for isolation, detection and killing of multiple bacterial pathogens.

Graphical abstract: Antimicrobial peptide based magnetic recognition elements and Au@Ag-GO SERS tags with stable internal standards: a three in one biosensor for isolation, discrimination and killing of multiple bacteria in whole blood
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A high performance lithium-ion–sulfur battery with a free-standing carbon matrix supported Li-rich alloy anode

A high-performance lithium-ion–sulfur battery has been built by using a carbon supported Li-rich alloy anode and sulfurized polyacrylonitrile (S@pPAN) cathode.

Graphical abstract: A high performance lithium-ion–sulfur battery with a free-standing carbon matrix supported Li-rich alloy anode
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Silver-mediated oxidative functionalization of alkylsilanes

A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported.

Graphical abstract: Silver-mediated oxidative functionalization of alkylsilanes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces

2D coordination polymers grow spontaneously on reactive surfaces due to surface oxidation. The growth process is observed in real time.

Graphical abstract: Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Chiral molecular face-rotating sandwich structures constructed through restricting the phenyl flipping of tetraphenylethylene

Complex arrangements of tetraphenylethylene motifs resulted in a variety of chiralities of face-rotating sandwich structures (FRSs).

Graphical abstract: Chiral molecular face-rotating sandwich structures constructed through restricting the phenyl flipping of tetraphenylethylene
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Enzyme-free molecular catalytic device: dynamically self-assembled DNA dendrimers for in situ imaging of microRNAs in live cells

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Total Synthesis of Micrococcin P1 and Thiocillin I Enabled by Mo(VI) Catalyst

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Polyketide–polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood.

Graphical abstract: Dalmanol biosyntheses require coupling of two separate polyketide gene clusters
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Mapping the polymorphic transformation gateway vibration in crystalline 1,2,4,5-tetrabromobenzene

A single lattice vibration at 15.5 cm−1 serves as a gateway for the polymorphic conversion of thermosalient 1,2,4,5-tetrabromobenzene crystals.

Graphical abstract: Mapping the polymorphic transformation gateway vibration in crystalline 1,2,4,5-tetrabromobenzene
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Sodium-coupled electron transfer reactivity of metal–organic frameworks containing titanium clusters: the importance of cations in redox chemistry

Storage of electrons in the Ti8O8 nodes of MOF MIL-125 is controlled by the presence of charge-balancing Na+ cations.

Graphical abstract: Sodium-coupled electron transfer reactivity of metal–organic frameworks containing titanium clusters: the importance of cations in redox chemistry
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Color-tunable lanthanide metal-organic framework gels

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Electrocatalytic reduction of low concentration CO2

Electrocatalytic reduction of low concentration CO2 was selectively and efficiently carried out by using a Re(I) complex with high CO2-capturing ability.

Graphical abstract: Electrocatalytic reduction of low concentration CO2
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Shape-selective crystallisation of fluxional carbon cages

Overall molecular shape, rather than any specific noncovalent interactions, controls the preferential crystallisation of shapeshifting barbaralane isomers from dynamic mixtures.

Graphical abstract: Shape-selective crystallisation of fluxional carbon cages
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Computational design of a molecular triple photoswitch for wavelength-selective control

meta-Trisazobenzenes allow for wavelength-selective photo-switching of the individual azobenzene branches.

Graphical abstract: Computational design of a molecular triple photoswitch for wavelength-selective control
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Realization of high-power-efficiency white electroluminescence from a single polymer by energy-level engineering

Single white light-emitting polymers with a record power efficiency of 52.1 lm W−1 are realized by energy-level engineering of poly(arylene phosphine oxide)-based phosphorescent polymers.

Graphical abstract: Realization of high-power-efficiency white electroluminescence from a single polymer by energy-level engineering
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Atomic structure of boron resolved using machine learning and global sampling

Here, by combining machine learning with the latest stochastic surface walking (SSW) global optimization, we explore for the first time the potential energy surface of β-B.

Graphical abstract: Atomic structure of boron resolved using machine learning and global sampling
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Single Ru atoms with precise coordination on a monolayer layered double hydroxide for efficient electrooxidation catalysis

Single Ru atoms are uniquely located on the top of trivalence Fe atom of NiFe layered double hydroxide.

Graphical abstract: Single Ru atoms with precise coordination on a monolayer layered double hydroxide for efficient electrooxidation catalysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Self-assembled M12L24 nanospheres as a reaction vessel to facilitate a dinuclear Cu(I) catalyzed cyclization reaction

The application of large M12L24 nanospheres allows the pre-concentration of catalysts to reach high local concentrations, facilitating reactions that proceed through dinuclear mechanisms.

Graphical abstract: Self-assembled M12L24 nanospheres as a reaction vessel to facilitate a dinuclear Cu(i) catalyzed cyclization reaction
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A lithium-ion-active aerolysin nanopore for effectively trapping long single-stranded DNA

By developing lithium-ion-active aerolysin, for the first time we have achieved aerolysin detection of single-stranded DNA longer than 100 nt.

Graphical abstract: A lithium-ion-active aerolysin nanopore for effectively trapping long single-stranded DNA
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Tailored homo- and hetero- lanthanide porphyrin dimers: a synthetic strategy for integrating multiple spintronic functionalities into a single molecule

We present molecular magnetic systems that contain all elements necessary for spin-valve control in molecular spintronic devices in a single molecule.

Graphical abstract: Tailored homo- and hetero- lanthanide porphyrin dimers: a synthetic strategy for integrating multiple spintronic functionalities into a single molecule
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A glucose/O2 fuel cell-based self-powered biosensor for probing a drug delivery model with self-diagnosis and self-evaluation

A highly compact and self-sustained in vitro “diagnosis-therapy-evaluation” platform is developed by integrating a glucose/O2 fuel cell-based biosensor with a drug delivery system.

Graphical abstract: A glucose/O2 fuel cell-based self-powered biosensor for probing a drug delivery model with self-diagnosis and self-evaluation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

An evolutionary algorithm for the discovery of porous organic cages

An evolutionary algorithm is developed and used to search for shape persistent porous organic cages.

Graphical abstract: An evolutionary algorithm for the discovery of porous organic cages
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Defying strain in the synthesis of an electroactive bilayer helicene

Visible-light-induced oxidative cyclization of a phenanthrene framework overcomes immense strain to yield a bilayer perylene-diimide helicene.

Graphical abstract: Defying strain in the synthesis of an electroactive bilayer helicene
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A highly soluble, crystalline covalent organic framework compatible with device implementation

We report a soluble yet crystalline covalent organic framework (COF) by regulation of inter-layer interactions, which endows the COF with remarkable solubility and processability of thin films for optoelectronic devices that exhibit high yet anisotropic conductivities and outperform all the other COF-based semiconductors.

Graphical abstract: A highly soluble, crystalline covalent organic framework compatible with device implementation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fluorogenic atom transfer radical polymerization in aqueous media as a strategy for detection

A new method for detecting polymerization and amplifying initiator signals is established by fluorogenic atom transfer radical polymerization.

Graphical abstract: Fluorogenic atom transfer radical polymerization in aqueous media as a strategy for detection
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Chemical and photochemical DNA “gears” reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels

Stimuli-responsive polyacrylamide hydrogels crosslinked by glucosamine–boronate/G-quadruplexes or azobenzene-functionalized DNA reveal controlled stiffness using chemical or photochemical triggers.

Graphical abstract: Chemical and photochemical DNA “gears” reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions

The fluorescence of fluorescent proteins with noncovalently encapsulated chromophore is enhanced by complex interactions between chromophore, protein and bound water.

Graphical abstract: Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Reductive cleavage of C[double bond, length as m-dash]C bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S

Four effective probes with turn-off to turn-on fluorescence switches were successfully applied for sensing H2S.

Graphical abstract: Reductive cleavage of C [[double bond, length as m-dash]] C bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst.

Graphical abstract: Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study

Ion-mobility mass spectrometry and DFT calculations reveal the surprisingly solvent-dependent formation of large pentameric [N⋯I+⋯N] halogen-bonded capsules.

Graphical abstract: Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2

We investigated the binding mechanism of PI(4,5)P2 and variants on the inwardly rectifying potassium channel, Kir2.2. Our results not only demonstrated the molecular origin for their binding specificity, but also revealed the major driving forces.

Graphical abstract: Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols

We report an efficient and economical method for remote δ C(sp3)–H heteroarylation of free aliphatic alcohols using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis.

Graphical abstract: Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR

A fast NMR data acquisition strategy is explored to detect and characterize carbocations on solid zeolites.

Graphical abstract: Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice

ClO1, a ratiometric fluorescent probe, effectively captured endogenous HClO in the lungs of a lipopolysaccharide (LPS)-induced lung inflammation mouse model after intravenous administration.

Graphical abstract: Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc

A glycopeptide bearing a bisecting glucosamine, a rare N-glycan branch, and two LewisX trisaccharides was synthesized for the first time.

Graphical abstract: Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Single-molecule photoredox catalysis

Photocatalytic dehalogenation by a common dyestuff under aqueous conditions is driven by energy-additive absorption of two photons on the single-molecule level.

Graphical abstract: Single-molecule photoredox catalysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Nuclear singlet multimers (NUSIMERs) with long-lived singlet states

We are introducing nuclear spin singlet multimers which are molecules that contain several nuclear singlet states that can be populated at the same time.

Graphical abstract: Nuclear singlet multimers (NUSIMERs) with long-lived singlet states
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET

FRET and rolling circle amplification outperform RT-qPCR for microRNA diagnostics in clinical samples.

Graphical abstract: Advanced microRNA-based cancer diagnostics using amplified time-gated FRET
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes

A series of rare earth complexes of the form Ln(LR)3 supported by bidentate ortho-aryloxide–NHC ligands are reported (LR = O(o-C6H2tBu2-2,6-CN(C2H2)NR); R = iPr, tBu, Mes; Ln = Ce, Sm, Eu).

Graphical abstract: Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source

A convenient, miniaturized reverse electrodialysis battery to provide long-lasting and reliable ionic electricity is developed.

Graphical abstract: A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Unravelling the origins of ice nucleation on organic crystals

Organic molecules such as steroids or amino acids form crystals that can facilitate the formation of ice – arguably the most important phase transition on earth.

Graphical abstract: Unravelling the origins of ice nucleation on organic crystals
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Reversibility and reactivity in an acid catalyzed cyclocondensation to give furanochromanes – a reaction at the ‘oxonium-Prins’ vs.ortho-quinone methide cycloaddition’ mechanistic nexus

Herein we report a combined experimental and computational investigation of the acid catalyzed cyclocondensation reaction between styrenyl homoallylic alcohols and salicylaldehyde to form furanochromanes.

Graphical abstract: Reversibility and reactivity in an acid catalyzed cyclocondensation to give furanochromanes – a reaction at the ‘oxonium-Prins’ vs. ‘ortho-quinone methide cycloaddition’ mechanistic nexus
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells

We describe an enzyme-regulated liberation strategy to in situ generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.

Graphical abstract: An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Protonated glycine supramolecular systems: the need for quantum dynamics

Quantum mechanical simulations unequivocally explain experimental IR spectra of protonated supramolecular systems.

Graphical abstract: Protonated glycine supramolecular systems: the need for quantum dynamics
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis

The first direct syntheses, structural characterizations, and reactivity studies of multinuclear iron–phenyl species formed upon reaction of Fe(acac)3 and PhMgBr in THF are described.

Graphical abstract: Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylates

Polyelectrolyte/microemulsion complexes (PEMECs) are very versatile hybrid systems, combining high loading capacities of microemulsions with larger-scale structuring induced by polyelectrolytes.

Graphical abstract: Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylates
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation domain.

Graphical abstract: The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid

The identification of trace components from an individual cell can require derivatization under mild conditions for successful analysis by mass spectrometry (MS).

Graphical abstract: High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Direct observation of the intermediate in an ultrafast isomerization

Using a combination of two-dimensional infrared (2D IR) and variable temperature Fourier transform infrared (FTIR) spectroscopies the rapid structural isomerization of a five-coordinate ruthenium complex is investigated.

Graphical abstract: Direct observation of the intermediate in an ultrafast isomerization
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO

A new approach to increasing the faradaic efficiency of dye-sensitised photocathodes for H2 evolution from water is described, using integrated photocatalysts based on a ruthenium 4,4′-diethoxycarboxy-2,2′-bipyridine chromophore linked via terpyridine or triazole to a Pd or Pt-based H+ reduction catalyst.

Graphical abstract: Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones

The study of a selective palladium(II)-catalyzed C(sp3)–H acetoxylation reaction on a class of cyclic alkyl amines is reported.

Graphical abstract: Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones

Acylhydrazone-based constitutional dynamic networks respond to three agents by interesting multi-adaptive behavior for processing molecular information through constituent distributions.

Graphical abstract: Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Cs3VO(O2)2CO3: an exceptionally thermostable carbonatoperoxovanadate with an extremely large second-harmonic generation response

A highly thermostable carbonatoperoxovanadate, Cs3VO(O2)2CO3, exhibits a remarkably strong SHG response of approximately 23.0 times that of KDP, which is the largest among those of the reported NLO carbonate materials.

Graphical abstract: Cs3VO(O2)2CO3: an exceptionally thermostable carbonatoperoxovanadate with an extremely large second-harmonic generation response
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Chimera: enabling hierarchy based multi-objective optimization for self-driving laboratories

Chimera enables multi-target optimization for experimentation or expensive computations, where evaluations are the limiting factor.

Graphical abstract: Chimera: enabling hierarchy based multi-objective optimization for self-driving laboratories
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials

Microscale uniformity and long-range cohesion in multi-functional films assembled through drop-casting is realized by in situ gelation of monodisperse building blocks.

Graphical abstract: Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

The double-faced Janus lectin, designed by assembling sialic acid and fucose-specific lectin, organize multivalent heteroglyco compounds in mulitlayered material, and glycosylated protocells in prototissues.

Graphical abstract: Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams

A palladium(II)-catalysed C(sp3)–H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described.

Graphical abstract: Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents

The direct Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes have been accomplished using aniline as the transient ligand and alkyl boron reagents as the coupling partner.

Graphical abstract: Ir(iii)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Enhanced annihilation electrochemiluminescence by nanofluidic confinement

The generation of stable enhanced light emission by electrochemiluminescence in microfabricated nanofluidic electrochemical devices is demonstrated for the first time by exploiting nanogap amplification.

Graphical abstract: Enhanced annihilation electrochemiluminescence by nanofluidic confinement
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions

A post-transition state bifurcation (PTSB) involved in a Pummerer-type rearrangement is characterized using density functional theory (DFT) calculations on potential energy stationary points and direct dynamics simulations.

Graphical abstract: Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(III) protoporphyrin IX and its application as a supramolecular photosensitizer

A 4-aminoquinoline-based molecular tweezer was developed as a synthetic receptor for protoporphyrin IX and iron(III) protoporphyrin IX, and applied as a supramolecular photosensitizer.

Graphical abstract: Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Biocatalyst–artificial metalloenzyme cascade based on alcohol dehydrogenase

Alcohol dehydrogenase with a dual role: host for metal catalysts and enzyme for ketone reduction.

Graphical abstract: Biocatalyst–artificial metalloenzyme cascade based on alcohol dehydrogenase
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production

Synthetic biology techniques coupled with heterologous secondary metabolite production offer opportunities for the discovery and optimisation of natural products.

Graphical abstract: Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production
From the themed collection: 2018 ChemSci Pick of the Week Collection
140 items - Showing page 1 of 2

About this collection

This on-going web collection showcases all of the HOT Chemical Science articles published in 2018, as recommended by referees. Congratulations to all of the authors whose articles are featured.

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