Jump to main content
Jump to site search

Themed collection 2018 Chemical Science HOT Article Collection

113 items - Showing page 1 of 2
Open Access Accepted Manuscript - Edge Article

Reversibility and reactivity in an acid catalyzed cyclocondensation to give furanochromanes – A reaction at the ‘oxonium-Prins’ vs. ‘ortho-quinone methide cycloaddition’ mechanistic nexus

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Tailored Homo- and Hetero- Lanthanide Porphyrin Dimers: a Synthetic Strategy for Integrating Multiple Spintronic Functionalities into a Single Molecule

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation domain.

Graphical abstract: The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR

A fast NMR data acquisition strategy is explored to detect and characterize carbocations on solid zeolites.

Graphical abstract: Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid

The identification of trace components from an individual cell can require derivatization under mild conditions for successful analysis by mass spectrometry (MS).

Graphical abstract: High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Glucose/O2 Fuel Cell-Based Self-Powered Biosensor for Probing Drug Delivery Model with Self-Diagnosis and Self-Evaluation

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions

The fluorescence of fluorescent proteins with noncovalently encapsulated chromophore is enhanced by complex interactions between chromophore, protein and bound water.

Graphical abstract: Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Direct observation of the intermediate in an ultrafast isomerization

Using a combination of two-dimensional infrared (2D IR) and variable temperature Fourier transform infrared (FTIR) spectroscopies the rapid structural isomerization of a five-coordinate ruthenium complex is investigated.

Graphical abstract: Direct observation of the intermediate in an ultrafast isomerization
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO

A new approach to increasing the faradaic efficiency of dye-sensitised photocathodes for H2 evolution from water is described, using integrated photocatalysts based on a ruthenium 4,4′-diethoxycarboxy-2,2′-bipyridine chromophore linked via terpyridine or triazole to a Pd or Pt-based H+ reduction catalyst.

Graphical abstract: Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones

The study of a selective palladium(II)-catalyzed C(sp3)–H acetoxylation reaction on a class of cyclic alkyl amines is reported.

Graphical abstract: Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones

Acylhydrazone-based constitutional dynamic networks respond to three agents by interesting multi-adaptive behavior for processing molecular information through constituent distributions.

Graphical abstract: Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Cs3VO(O2)2CO3: an exceptionally thermostable carbonatoperoxovanadate with an extremely large second-harmonic generation response

A highly thermostable carbonatoperoxovanadate, Cs3VO(O2)2CO3, exhibits a remarkably strong SHG response of approximately 23.0 times that of KDP, which is the largest among those of the reported NLO carbonate materials.

Graphical abstract: Cs3VO(O2)2CO3: an exceptionally thermostable carbonatoperoxovanadate with an extremely large second-harmonic generation response
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Chimera: enabling hierarchy based multi-objective optimization for self-driving laboratories

Chimera enables multi-target optimization for experimentation or expensive computations, where evaluations are the limiting factor.

Graphical abstract: Chimera: enabling hierarchy based multi-objective optimization for self-driving laboratories
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials

Microscale uniformity and long-range cohesion in multi-functional films assembled through drop-casting is realized by in situ gelation of monodisperse building blocks.

Graphical abstract: Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

The double-faced Janus lectin, designed by assembling sialic acid and fucose-specific lectin, organize multivalent heteroglyco compounds in mulitlayered material, and glycosylated protocells in prototissues.

Graphical abstract: Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams

A palladium(II)-catalysed C(sp3)–H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described.

Graphical abstract: Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

An enzyme-activatable probe liberating AIEgen: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents

The direct Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes have been accomplished using aniline as the transient ligand and alkyl boron reagents as the coupling partner.

Graphical abstract: Ir(iii)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Enhanced annihilation electrochemiluminescence by nanofluidic confinement

The generation of stable enhanced light emission by electrochemiluminescence in microfabricated nanofluidic electrochemical devices is demonstrated for the first time by exploiting nanogap amplification.

Graphical abstract: Enhanced annihilation electrochemiluminescence by nanofluidic confinement
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes

A series of rare earth complexes of the form Ln(LR)3 supported by bidentate ortho-aryloxide–NHC ligands are reported (LR = O(o-C6H2tBu2-2,6-CN(C2H2)NR); R = iPr, tBu, Mes; Ln = Ce, Sm, Eu).

Graphical abstract: Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions

A post-transition state bifurcation (PTSB) involved in a Pummerer-type rearrangement is characterized using density functional theory (DFT) calculations on potential energy stationary points and direct dynamics simulations.

Graphical abstract: Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Protonated glycine supramolecular systems: the need for quantum dynamics

Quantum mechanical simulations unequivocally explain experimental IR spectra of protonated supramolecular systems.

Graphical abstract: Protonated glycine supramolecular systems: the need for quantum dynamics
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(III) protoporphyrin IX and its application as a supramolecular photosensitizer

A 4-aminoquinoline-based molecular tweezer was developed as a synthetic receptor for protoporphyrin IX and iron(III) protoporphyrin IX, and applied as a supramolecular photosensitizer.

Graphical abstract: Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Biocatalyst–artificial metalloenzyme cascade based on alcohol dehydrogenase

Alcohol dehydrogenase with a dual role: host for metal catalysts and enzyme for ketone reduction.

Graphical abstract: Biocatalyst–artificial metalloenzyme cascade based on alcohol dehydrogenase
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production

Synthetic biology techniques coupled with heterologous secondary metabolite production offer opportunities for the discovery and optimisation of natural products.

Graphical abstract: Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation

Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.

Graphical abstract: Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy

Aptamer conjugated porphyrinic metal–organic framework (MOF) achieved target-induced bioimaging and photodynamic therapy.

Graphical abstract: ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Hierarchical tandem assembly of planar [3×3] building units into {3×[3×3]} oligomers: mixed-valency, electrical conductivity and magnetism

Electrical conductors are made from flat grid clusters of copper using mixed-valency and supramolecular interactions between the enveloping organic ligands.

Graphical abstract: Hierarchical tandem assembly of planar [3×3] building units into {3×[3×3]} oligomers: mixed-valency, electrical conductivity and magnetism
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in Helicobacter pylori on bismuth treatment

Integration of multi-omics analyses uncovers the dynamic responses of H. pylori upon bismuth treatment.

Graphical abstract: Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in Helicobacter pylori on bismuth treatment
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(IV) active centers of nano-MOFs

We describe a kind of Zr(IV)-based nano-MOF that is well suited for specific adsorption and selective fluorescence sensing of phosphate based on specific interactions between Zr(IV) and phosphate which provides a new approach for treatment of hyperphosphatemia.

Graphical abstract: Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Silver-mediated oxidative functionalization of alkylsilanes

A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported.

Graphical abstract: Silver-mediated oxidative functionalization of alkylsilanes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A high performance lithium-ion–sulfur battery with a free-standing carbon matrix supported Li-rich alloy anode

A high-performance lithium-ion–sulfur battery has been built by using a carbon supported Li-rich alloy anode and sulfurized polyacrylonitrile (S@pPAN) cathode.

Graphical abstract: A high performance lithium-ion–sulfur battery with a free-standing carbon matrix supported Li-rich alloy anode
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces

2D coordination polymers grow spontaneously on reactive surfaces due to surface oxidation. The growth process is observed in real time.

Graphical abstract: Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Chiral molecular face-rotating sandwich structures constructed through restricting the phenyl flipping of tetraphenylethylene

Complex arrangements of tetraphenylethylene motifs resulted in a variety of chiralities of face-rotating sandwich structures (FRSs).

Graphical abstract: Chiral molecular face-rotating sandwich structures constructed through restricting the phenyl flipping of tetraphenylethylene
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Computational design of a molecular triple photoswitch for wavelength-selective control

meta-Trisazobenzenes allow for wavelength-selective photo-switching of the individual azobenzene branches.

Graphical abstract: Computational design of a molecular triple photoswitch for wavelength-selective control
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Realization of high-power-efficiency white electroluminescence from a single polymer by energy-level engineering

Single white light-emitting polymers with a record power efficiency of 52.1 lm W−1 are realized by energy-level engineering of poly(arylene phosphine oxide)-based phosphorescent polymers.

Graphical abstract: Realization of high-power-efficiency white electroluminescence from a single polymer by energy-level engineering
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET

FRET and rolling circle amplification outperform RT-qPCR for microRNA diagnostics in clinical samples.

Graphical abstract: Advanced microRNA-based cancer diagnostics using amplified time-gated FRET
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism Thermogemmatispora strain T81

Tikitericin, a novel lanthipeptide was isolated and characterised together with its first total synthesis.

Graphical abstract: Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism Thermogemmatispora strain T81
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Facile room temperature synthesis of large graphene sheets from simple molecules

The simplest way to produce large graphene sheets starting from simple molecules (benzene or n-hexane) under ambient conditions (temperature and pressure).

Graphical abstract: Facile room temperature synthesis of large graphene sheets from simple molecules
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation

By successively replacing H+ by Na+ or K+ in phosphopeptide anions and cations, we show that the efficiency of fragmentation into c and z˙ or c˙ and z fragments from N–Cα backbone bond cleavage by negative ion electron capture dissociation (niECD) and electron capture dissociation (ECD) substantially decreases with increasing number of alkali ions attached.

Graphical abstract: Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Reversible coordination of N2 and H2 to a homoleptic S = 1/2 Fe(I) diphosphine complex in solution and the solid state

A 15 valence-electron Fe(I) species rapidly and reversibly binds N2 and H2, the latter producing a rare paramagnetic dihydrogen complex.

Graphical abstract: Reversible coordination of N2 and H2 to a homoleptic S = 1/2 Fe(i) diphosphine complex in solution and the solid state
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Bright insights into palladium-triggered local chemotherapy

We report fundamental insights into the validity, reliability and clinical feasibility of using heterogeneous Pd catalysts as implantable devices to accurately activate chemotherapy within a tumour.

Graphical abstract: Bright insights into palladium-triggered local chemotherapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Disarming the virulence arsenal of Pseudomonas aeruginosa by blocking two-component system signaling

Pseudomonas aeruginosa infections have reached a “critical” threat status making novel therapeutic approaches required.

Graphical abstract: Disarming the virulence arsenal of Pseudomonas aeruginosa by blocking two-component system signaling
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)–H bond functionalization

Highly diastereoselective synthesis of tricyclic fused-pyrans was achieved by Brønsted acid catalyzed double C(sp3)–H bond functionalization.

Graphical abstract: Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)–H bond functionalization
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Atomic structure of boron resolved using machine learning and global sampling

Here, by combining machine learning with the latest stochastic surface walking (SSW) global optimization, we explore for the first time the potential energy surface of β-B.

Graphical abstract: Atomic structure of boron resolved using machine learning and global sampling
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

An evolutionary algorithm for the discovery of porous organic cages

An evolutionary algorithm is developed and used to search for shape persistent porous organic cages.

Graphical abstract: An evolutionary algorithm for the discovery of porous organic cages
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Reductive cleavage of C[double bond, length as m-dash]C bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S

Four effective probes with turn-off to turn-on fluorescence switches were successfully applied for sensing H2S.

Graphical abstract: Reductive cleavage of C [[double bond, length as m-dash]] C bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst.

Graphical abstract: Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2

We investigated the binding mechanism of PI(4,5)P2 and variants on the inwardly rectifying potassium channel, Kir2.2. Our results not only demonstrated the molecular origin for their binding specificity, but also revealed the major driving forces.

Graphical abstract: Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Conformational selectivity and high-affinity binding in the complexation of N-phenyl amides in water by a phenyl extended calix[4]pyrrole

We report the synthesis of a tetrapyridinium phenyl extended calix[4]pyrrole receptor that shows high binding affinity and selectivity for the complexation of the cis-conformers of N-phenyl amides in water.

Graphical abstract: Conformational selectivity and high-affinity binding in the complexation of N-phenyl amides in water by a phenyl extended calix[4]pyrrole
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study

Ion-mobility mass spectrometry and DFT calculations reveal the surprisingly solvent-dependent formation of large pentameric [N⋯I+⋯N] halogen-bonded capsules.

Graphical abstract: Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice

ClO1, a ratiometric fluorescent probe, effectively captured endogenous HClO in the lungs of a lipopolysaccharide (LPS)-induced lung inflammation mouse model after intravenous administration.

Graphical abstract: Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Facile and systematic access to the least-coordinating WCA [(RFO)3Al–F–Al(ORF)3] and its more Lewis-basic brother [F–Al(ORF)3] (RF = C(CF3)3)

The least-coordinating anion [(RFO)3Al–F–Al(ORF)3] and its more Lewis-basic brother [F–Al(ORF)3] (RF = C(CF3)3).

Graphical abstract: Facile and systematic access to the least-coordinating WCA [(RFO)3Al–F–Al(ORF)3]− and its more Lewis-basic brother [F–Al(ORF)3]− (RF = C(CF3)3)
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles

A series of chiral fluorescent macrocycles display a remarkable combination of both +/– ECD and strong on/off CPL reversible switching upon cation binding and displacement.

Graphical abstract: Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Tuning the reactivity of nitriles using Cu(II) catalysis – potentially prebiotic activation of nucleotides

A synergistic system was established involving activating nucleotides with nitriles using Cu(II) and protecting RNA degradation by byproducts of alpha-aminonitriles.

Graphical abstract: Tuning the reactivity of nitriles using Cu(ii) catalysis – potentially prebiotic activation of nucleotides
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc

A glycopeptide bearing a bisecting glucosamine, a rare N-glycan branch, and two LewisX trisaccharides was synthesized for the first time.

Graphical abstract: Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Unravelling the origins of ice nucleation on organic crystals

Organic molecules such as steroids or amino acids form crystals that can facilitate the formation of ice – arguably the most important phase transition on earth.

Graphical abstract: Unravelling the origins of ice nucleation on organic crystals
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source

A convenient, miniaturized reverse electrodialysis battery to provide long-lasting and reliable ionic electricity is developed.

Graphical abstract: A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis

The first direct syntheses, structural characterizations, and reactivity studies of multinuclear iron–phenyl species formed upon reaction of Fe(acac)3 and PhMgBr in THF are described.

Graphical abstract: Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Using machine learning, targets were identified for β-lapachone.

Graphical abstract: Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Unraveling reaction networks behind the catalytic oxidation of methane with H2O2 over a mixed-metal MIL-53(Al,Fe) MOF catalyst

Reaction paths underlying the catalytic oxidation of methane with H2O2 over an Fe containing MIL-53(Al) metal–organic framework were studied by periodic DFT calculations.

Graphical abstract: Unraveling reaction networks behind the catalytic oxidation of methane with H2O2 over a mixed-metal MIL-53(Al,Fe) MOF catalyst
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Supercooling of functional alkyl-π molecular liquids

The formation of a metastable supercooled alkyl-π molecular liquid was prohibited by subtle alteration of the molecular structure.

Graphical abstract: Supercooling of functional alkyl-π molecular liquids
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

A 1,8-naphthalimide-based two-photon fluorescent probe was designed to visualize MGO levels in living cells and a diabetic mice model.

Graphical abstract: Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Enhancement of triplet-sensitized upconversion in rigid polymers via singlet exciton sink approach

Quenching of emitter singlets by the sensitizer limits the efficiency of sensitized upconversion, unless an emissive exciton sink is employed.

Graphical abstract: Enhancement of triplet-sensitized upconversion in rigid polymers via singlet exciton sink approach
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Synthesis and structural characterization of inverse-coordination clusters from a two-electron superatomic copper nanocluster

Cuboctahedral copper clusters containing a twelve-coordinated main group element (Cl, Br, S) at the center have been synthesized and characterized.

Graphical abstract: Synthesis and structural characterization of inverse-coordination clusters from a two-electron superatomic copper nanocluster
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

We construct a tumor redox microenvironment responsive core–shell therapeutic nanoagent for multi-mode imaging guided synergistic therapy in vitro and in vivo.

Graphical abstract: A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Interfacing porphyrins and carbon nanotubes through mechanical links

U-shaped bisporphyrin molecules are clipped around SWCNTs using ring-closing metathesis yielding rotaxane-type derivatives, in which porphyrins and SWCNTs are connected through mechanical links.

Graphical abstract: Interfacing porphyrins and carbon nanotubes through mechanical links
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

An ultrasensitive flow cytometric immunoassay based on bead surface-initiated template-free DNA extension

An ultrasensitive flow cytometric immunoassay (TdT-FCI) is developed based on bead surface-initiated template-free DNA extension.

Graphical abstract: An ultrasensitive flow cytometric immunoassay based on bead surface-initiated template-free DNA extension
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Switchable gate-opening effect in metal–organic polyhedra assemblies through solution processing

Assemblies of lantern-type metal–organic polyhedra are found to show gate-opening gas adsorption depending on how they are treated with solvents.

Graphical abstract: Switchable gate-opening effect in metal–organic polyhedra assemblies through solution processing
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride.

Graphical abstract: Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
From the themed collection: 2018 Chemical Science HOT Article Collection
113 items - Showing page 1 of 2

About this collection

This on-going web collection showcases all of the HOT Chemical Science articles published in 2018, as recommended by referees. Congratulations to all of the authors whose articles are featured.

Spotlight

Advertisements