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Issue 44, 2018
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Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

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Abstract

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.

Graphical abstract: Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

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Publication details

The article was received on 12 Jul 2018, accepted on 31 Aug 2018 and first published on 06 Sep 2018


Article type: Edge Article
DOI: 10.1039/C8SC03081B
Citation: Chem. Sci., 2018,9, 8363-8368
  • Open access: Creative Commons BY-NC license
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    Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

    R. Matsuura, T. C. Jankins, D. E. Hill, K. S. Yang, G. M. Gallego, S. Yang, M. He, F. Wang, R. P. Marsters, I. McAlpine and K. M. Engle, Chem. Sci., 2018, 9, 8363
    DOI: 10.1039/C8SC03081B

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