Themed collection JAAS Recent Open Access Articles

Secondary ion mass spectrometry (SIMS) has been increasingly recognized as a powerful technique for visualizing molecular architectures in the fields of neurobiology and cell biology.

The critical review discusses instrumental developments in single particle ICP-MS (spICP-MS) of recent years step-by-step. Nanoanalysis application papers from the literature are summarized in a tabular form including important experimental parameters.

Specific labeling of cellular proteins with fluorinated nanobodies enables their visualization in nanoSIMS.

The scattering background in large-area X-ray fluorescence analysis (more than one square centimeter) has been greatly reduced by using highly polarized X-rays and by inserting a collimator plate between the sample and the detector.

Depth profiling of the n(²³⁵U)/n(²³⁸U) amount ratio in UO₂ single crystals employing LA-MC-ICP-MS, a dual beam focused ion beam and confocal laser scanning profilometry.

We present novel analytical methods allowing the precise determination of the uranium isotopic composition (²³⁸U/²³⁵U) of single zircon crystals.

Characterization of dissolved background signals as compound Poisson distributed enables more accurate and robust nanoparticle detection thresholds in single-particle ICP-TOFMS.

A compact spectrometer for laboratory NEXAFS measurements, allowing quantitative chemical analysis in the soft X-ray spectral range (250–1000 eV).

Mass spectrometry imaging used to measure hippocampal zinc shows complementarity to fluorescence and shows protein-bound rather than free zinc.

A new table-top combined spectrometer was designed and constructed consisting of X-ray fluorescence and Raman spectrometers for spot-analysis of elementary and chemical composition of solid and liquid substances for industrial analytical applications.

A new method for the quantification of dissolved ions and nanoparticles in mixtures with SP-ICP-MS with microsecond time resolution.

A newly developed laboratory-based double X-ray spectrometer enables systematic and simultaneous X-ray emission (XES) and X-ray absorption (XAS) measurements.

The article demonstrates how quantitative compositional depth profiles of Cu(In,Ga)(S,Se)₂ layers can be utilized to determine their energy bandgap distribution.

ToF-SIMS boundaries were pushed to enhance lateral resolution and mass resolving power for chemical imaging of nanoparticles in biological systems.

This work reports laboratory angle resolved XRF measurements with the goal of establishing laboratory techniques to obtain a more complete idea of the intralayer composition of multilayer samples.

Microdroplets with known concentrations of element standards are introduced concomitant with NP-containing solutions into the ICP to provide online matrix-matched calibration of analyte NPs for single-particle-ICP-TOFMS.

Novel layer-by-layer ablation protocol for sensitive chemical depth profiling measurements of micrometer-sized samples.

The capabilities of flow injection inductively coupled plasma time-of-flight mass spectrometry (FI-ICP-TOFMS) were evaluated for accurate multi-element analysis addressing water and serum reference materials with a sample intake of 5 μL in comparison to FI-ICP-MS/MS analysis.

Screening tool for metal-based anticancer drugs enabled by on-line heart-cut two-dimensional liquid chromatography combined with ICP-MS (2DLC-ICP-MS).

Isotopic compositions of two S-33 enriched sulfur standards were assessed for the normalization of Δ³³S and Δ³⁶S data, to fulfill the need of accurate message extraction from S-MIF signals in atmospheric and geological samples.