Matters of class: coming of age of class III and IV lanthipeptides
In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.
The chemical biology of IL-12 production via the non-canonical NFkB pathway
Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors.
Synthetic hyperacetylation of nucleosomal histones
A chemical catalyst system enabling high-yielding and comprehensive lysine acetylation of nucleosomal histones was developed as an epigenetics tool.
Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome
Bifunctional peptides targeting both the translation and the replication machineries have been developed and shown to act as new antimicrobials.
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
Investigation of the downstream effects of NMT inhibition identified novel defense mechanism against chemical toxicity in fungal pathogen Z. tritici.
A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
UDP-N-acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide.
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