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Themed collection RSC Chemical Biology Transparent Peer Review Collection

6 items
Open Access Review Article

Matters of class: coming of age of class III and IV lanthipeptides

In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.

Graphical abstract: Matters of class: coming of age of class III and IV lanthipeptides
Open Access Review Article

The chemical biology of IL-12 production via the non-canonical NFkB pathway

Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors.

Graphical abstract: The chemical biology of IL-12 production via the non-canonical NFkB pathway
Open Access Communication

Synthetic hyperacetylation of nucleosomal histones

A chemical catalyst system enabling high-yielding and comprehensive lysine acetylation of nucleosomal histones was developed as an epigenetics tool.

Graphical abstract: Synthetic hyperacetylation of nucleosomal histones
Open Access Paper

Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome

Bifunctional peptides targeting both the translation and the replication machineries have been developed and shown to act as new antimicrobials.

Graphical abstract: Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome
Open Access Paper

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism

Investigation of the downstream effects of NMT inhibition identified novel defense mechanism against chemical toxicity in fungal pathogen Z. tritici.

Graphical abstract: Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
From the themed collection: Celebrating our 2020 Prize and Award winners
Open Access Paper

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

UDP-N-acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide.

Graphical abstract: A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
6 items

About this collection

In the interest of transparency and open science, RSC Chemical Biology is the first Royal Society of Chemistry journal to offer our authors the option of transparent peer review, where the editor’s decision letter, reviewers’ comments and authors’ response for all versions of the manuscript are published alongside the article under an Open Access Creative Commons licence (CC-BY). Authors are asked if they would like to take up this option at the revision stages. Reviewer comments will remain anonymous unless the individual chooses to sign their report.

For more information, please contact us.

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