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Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research

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Abstract

Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and greater patient longevity, means for early detection and severity stratification have failed to keep pace. Detection and validation of cancer-specific biomarkers hinges on the ability to identify subtype-specific phenotypic and proteomic alterations and the systematic screening of diverse patient groups. For this reason, clinical and scientific research settings rely on high throughput and high sensitivity mass spectrometry methods to discover and quantify unique molecular perturbations in cancer patients. Discussed within is an overview of quantitative proteomics strategies and a summary of recent applications that enable revealing potential biomarkers and treatment targets in prostate, ovarian, breast, and pancreatic cancer in a high throughput manner.

Graphical abstract: Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research

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Article information


Submitted
01 Mar 2021
Accepted
18 May 2021
First published
19 May 2021

This article is Open Access

RSC Chem. Biol., 2021, Advance Article
Article type
Review Article

Recent developments and applications of quantitative proteomics strategies for high-throughput biomolecular analyses in cancer research

H. N. Miles, D. G. Delafield and L. Li, RSC Chem. Biol., 2021, Advance Article , DOI: 10.1039/D1CB00039J

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