Issue 2, 2020

Synthetic hyperacetylation of nucleosomal histones


We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopus laevis sperm chromatin.

Graphical abstract: Synthetic hyperacetylation of nucleosomal histones

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Article information

Article type
11 Mar 2020
29 Apr 2020
First published
19 May 2020
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2020,1, 56-59

Synthetic hyperacetylation of nucleosomal histones

H. Kajino, T. Nagatani, M. Oi, T. Kujirai, H. Kurumizaka, A. Nishiyama, M. Nakanishi, K. Yamatsugu, S. A. Kawashima and M. Kanai, RSC Chem. Biol., 2020, 1, 56 DOI: 10.1039/D0CB00029A

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