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Themed collection Catalysis & biocatalysis in OBC

142 items - Showing page 1 of 3
Accepted Manuscript - Review Article

Metal-Catalysed Reactions Enabled by Guanidine-Type Ligands

From the themed collection: Catalysis & biocatalysis in OBC
Accepted Manuscript - Paper

Gold-carbene assisted formation of tetraarylmethane derivatives: Double X-H activation by gold

From the themed collection: Catalysis & biocatalysis in OBC
Communication

Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes

A new chiral monodentate spiro phosphoramidite ligand based on a hexamethyl-1,1′-spirobiindane scaffold has been developed and applied in Pd-catalyzed asymmetric hydroamination/arylation of alkenes.

Graphical abstract: Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Rh(III)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

Directing group ONHR preserved ortho-alkynylation under mild conditions catalyzed by rhodium is reported.

Graphical abstract: Rh(iii)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling.

Graphical abstract: Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation

Hydrosilylation of imines was achieved using a redox non-innocent Fe-BIAN catalyst and employing the inexpensive trialkoxysilane (EtO)3SiH.

Graphical abstract: Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates

An electrochemical Hofmann rearrangement is reported, which provides general and practical access to bioactive carbamates.

Graphical abstract: Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines

A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope.

Graphical abstract: Iron(iii)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Palladium-catalyzed heck-type cascade cyclization of (Z)-1-iodo-1,6-dienes with N-tosyl hydrazones

A new way to synthesize tetrahydropyridine derivatives bearing a terminal alkene due to highly regioselective β-H elimination of alkylpalladium species.

Graphical abstract: Palladium-catalyzed heck-type cascade cyclization of (Z)-1-iodo-1,6-dienes with N-tosyl hydrazones
From the themed collection: Catalysis & biocatalysis in OBC
Paper

KIO3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature

A metal-free direct sulfenylation of phenol and arylamine derivatives with various heterocyclic thiols and thiones using a cross dehydrogenative coupling protocol in water at room temperature has been developed.

Graphical abstract: KIO3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature
From the themed collection: Synthetic methodology in OBC
Communication

Direct enantio- and diastereoselective Mannich reactions of isatin-derived ketimines with oxo-indanecarboxylates catalyzed by chiral thiourea derived from hydroquinidine

A series of 3-substituted 3-amino-oxindoles were constructed by this protocol in excellent yields (92–99%) with high enantioselectivities (85–99% ee) and diastereoselectivities (up to >99 : 1 dr).

Graphical abstract: Direct enantio- and diastereoselective Mannich reactions of isatin-derived ketimines with oxo-indanecarboxylates catalyzed by chiral thiourea derived from hydroquinidine
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

A chemoselective 1,2-reduction of cycloalkyl vinyl ketones to the corresponding chiral allylic alcohols via asymmetric transfer hydrogenation is described.

Graphical abstract: Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed arene amination in pure aqueous ammonia

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed.

Graphical abstract: Copper-catalyzed arene amination in pure aqueous ammonia
From the themed collection: Catalysis & biocatalysis in OBC
Communication

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed.

Graphical abstract: A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Mild synthesis of silyl ethers via potassium carbonate catalyzed reactions between alcohols and hydrosilanes

A method has been developed for the silanolysis of alcohols using an abundant and non-corrosive base K2CO3 as a catalyst.

Graphical abstract: Mild synthesis of silyl ethers via potassium carbonate catalyzed reactions between alcohols and hydrosilanes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Copper-catalyzed synthesis of 2,2,2-trifluoroethyl selenoethers and their insecticidal activities

A copper-catalyzed synthesis of aryl or alkyl 2,2,2-trifluoroethyl selenoethers was developed. Some of them exhibited promising insecticidal activities against tetranychus cinnabarinus.

Graphical abstract: Copper-catalyzed synthesis of 2,2,2-trifluoroethyl selenoethers and their insecticidal activities
From the themed collection: Catalysis & biocatalysis in OBC
Communication

An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions

A nucleophilic catalyst is introduced for facile radical formation and its catalyst controlled aerobic oxidation.

Graphical abstract: An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate

Visible-light induced perfluoroalkylation of the α-position of aldehydes via enamines.

Graphical abstract: Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate
From the themed collection: Synthetic methodology in OBC
Communication

Visible light mediated oxidative lactonization of 2-methyl-1,1′-biaryls for the synthesis of benzocoumarins

A visible light mediated C–H lactonization of 2-methyl-1,1′-biaryls with oxygen as the oxidant was developed, giving benzocoumarins in good yields.

Graphical abstract: Visible light mediated oxidative lactonization of 2-methyl-1,1′-biaryls for the synthesis of benzocoumarins
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols

An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between (E)-2-(2-nitrovinyl)phenols and 1,3-propanediones is disclosed to generate products having keto, ester and nitro functionalities.

Graphical abstract: Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides

We disclose herein a Ni-catalyzed benzyl C–O bond radical fragmentation/cross-electrophile coupling of benzyl chloroformates with aryl iodides to generate diaryl methane derivatives.

Graphical abstract: Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes

Simple cationic bis(phosphine)iridium complexes are shown to be highly selective catalysts for ether cleavage with silanes. Benzylic ethers can be cleaved under mild conditions in the presence of reductively-labile functional groups.

Graphical abstract: Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Anthracene–rhodium complexes with metal coordination at the central ring – a new class of catalysts for reductive amination

A new class of anthracene–metal complexes with central ring coordination was tested in catalysis. A simple and efficient protocol for reductive amination without an external hydrogen source has been developed.

Graphical abstract: Anthracene–rhodium complexes with metal coordination at the central ring – a new class of catalysts for reductive amination
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Various chiral seven-membered β-substituted lactams were successfully prepared through Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation with up to >99% conversion, 99% yield, and >99% ee.

Graphical abstract: Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates

Palladium-catalyzed selective synthesis of various 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates was developed.

Graphical abstract: Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines

The application of bifunctional catalysis for the synthesis of tetrahydro-1,2-oxazines is described.

Graphical abstract: Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Visible light-promoted difluoromethylthiolation of aryldiazonium salts

Difluoromethylthiolation of aryldiazonium salts under mild conditions using a shelf-stable reagent (PhSO2SCF2H) was reported.

Graphical abstract: Visible light-promoted difluoromethylthiolation of aryldiazonium salts
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles

A copper-catalyzed carbene/alkyne metathesis reaction of alkyne-tethered diazoacetates is reported, which provides dihydrocyclohepta[b]indole skeletons under mild reaction conditions.

Graphical abstract: Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Cobalt-catalyzed carbon–sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines

An efficient cobalt-catalyzed C–S/C–Se bond formation method for the synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines has been developed.

Graphical abstract: Cobalt-catalyzed carbon–sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Efficient synthesis of chiral β-hydroxy sulfones via iridium-catalyzed hydrogenation

A highly efficient Ir-catalyzed asymmetric hydrogenation of prochiral β-keto sulfones was successfully developed, affording a series of chiral β-hydroxy sulfones with excellent results (up to >99% conversion, 99% yield, >99% ee, and 20 000 TON).

Graphical abstract: Efficient synthesis of chiral β-hydroxy sulfones via iridium-catalyzed hydrogenation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Kinetic resolution of β-ketoesters with quaternary stereocenters via a carbene-catalyzed benzoin reaction

N-Heterocyclic carbene-catalyzed kinetic resolution is used to produce enantioenriched β-ketoesters with quaternary stereocenters. Sterically bulky substituents such as benzyl, allyl, phenyl and cyclopropyl groups are all tolerated in this method.

Graphical abstract: Kinetic resolution of β-ketoesters with quaternary stereocenters via a carbene-catalyzed benzoin reaction
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent advances in iodine mediated electrochemical oxidative cross-coupling

This review article gives an overview of the recent development of iodine mediated electrochemical oxidative coupling reactions.

Graphical abstract: Recent advances in iodine mediated electrochemical oxidative cross-coupling
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A nickel catalyzed acceptorless dehydrogenative approach to quinolines

A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare macrocyclic nickel catalyst [Ni(MeTAA)].

Graphical abstract: A nickel catalyzed acceptorless dehydrogenative approach to quinolines
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones

The direct addition of water to a carbon–carbon double bond remains a challenge, but such a reaction is essential for the development of efficient catalysts that enable direct access to chiral alcohols.

Graphical abstract: Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

The mechanistic duality of (thio)urea organocatalysts for ring-opening polymerization

Dual mechanisms for H-bond mediated ring-opening polymerization allow for precise control, high activity and new applications.

Graphical abstract: The mechanistic duality of (thio)urea organocatalysts for ring-opening polymerization
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis

The site-directed mutagenesis of FgaPT2 switches a regular C4-prenylation to a reverse C3-prenylation of tryptophan-containing cyclic dipeptides.

Graphical abstract: Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis
From the themed collection: Catalysis & biocatalysis in OBC
Paper

New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes

New amino alcohol ligands suitable for immobilization on nanoparticles were successfully used in catalytic enantioselective additions of diethylzinc to aldehydes.

Graphical abstract: New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains

Resorcylate acid lactone thioesterases can synthesize a variety of macrolactone and macrolactams, as well as a cyclicdepsipeptide.

Graphical abstract: Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains
From the themed collection: Synthetic methodology in OBC
Paper

Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst

Transition structure for the bifunctional thiourea catalyzed Michael addition using 13C KIEs and DFT calculations.

Graphical abstract: Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Asymmetric α-alkylation of cyclic β-keto esters and β-keto amides by phase-transfer catalysis

A facile and efficient asymmetric α-alkylation of β-keto esters and β-keto amides has been achieved by phase-transfer catalysis.

Graphical abstract: Asymmetric α-alkylation of cyclic β-keto esters and β-keto amides by phase-transfer catalysis
From the themed collection: Synthetic methodology in OBC
Paper

Enantioselective synthesis of pyrano[2,3-c]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones

The present work provides a simple and efficient access to chiral pyrano[2,3-c]pyrrole via an asymmetric [4 + 2] cyclization reaction catalyzed by a cinchona-squaramide catalyst.

Graphical abstract: Enantioselective synthesis of pyrano[2,3-c]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones
From the themed collection: Synthetic methodology in OBC
Communication

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases

Xyloglucan (XyG) is a complex polysaccharide that is ubiquitous and often abundant in the cell walls of terrestrial plants.

Graphical abstract: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions

Factors that affect the efficiency of amine transaminase catalyzed reactions using isopropylamine as an amine donor.

Graphical abstract: The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Organocatalyzed asymmetric tandem conjugate addition–protonation of isocyanoacetates to 2-chloroacrylonitrile

Dihydroquinine-derived thiourea catalyzed asymmetric tandem conjugate addition–protonation of α-isocyanoacetates to 2-chloroacrylonitrile was developed.

Graphical abstract: Organocatalyzed asymmetric tandem conjugate addition–protonation of isocyanoacetates to 2-chloroacrylonitrile
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Rhodium(III)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation

An efficient procedure for 6H-benzo[c]chromenes via a new Rh(III)-catalyzed domino annulation is described.

Graphical abstract: Rhodium(iii)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of (Z)-β-halo α,β-unsaturated carbonyl systems via the combination of halotrimethylsilane and tetrafluoroboric acid

A procedure for the stereoselective synthesis of β-halovinyl derivatives via a conjugate addition of HX to ynones has been developed.

Graphical abstract: Synthesis of (Z)-β-halo α,β-unsaturated carbonyl systems via the combination of halotrimethylsilane and tetrafluoroboric acid
From the themed collection: Synthetic methodology in OBC
Communication

Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes

The catalytic asymmetric synthesis of mono-fluoro-, -chloro- and -bromomethyl-1,2-diaryl ester cyclopropanes is described.

Graphical abstract: Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of indole-fused heteroacenes by cascade cyclisation involving rhodium(II)-catalysed intramolecular C–H amination

Indole-fused heteroacenes have been synthesised from cascade cyclisation of 2-[(2-azidophenyl)ethynyl]anilines and -phenols in a catalytic manner under redox-neutral conditions.

Graphical abstract: Synthesis of indole-fused heteroacenes by cascade cyclisation involving rhodium(ii)-catalysed intramolecular C–H amination
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles

Ru(II)-NHC catalyzes α-olefination of 2-oxindole via dehydrogenative coupling of 2-oxindole and diaryl methanol to generate selectively antimalarial 3-(diphenylmethylene)indolin-2-one derivatives.

Graphical abstract: Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles
From the themed collection: Synthetic methodology in OBC
Paper

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism

PKS dehydratases utilize a one-base mechanism.

Graphical abstract: pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Visible light-induced aerobic oxidative cross-coupling of glycine esters with α-angelicalactone: a facile pathway to γ-lactams

A rapid synthesis of substituted γ-lactams is achieved via metal-free photocatalyzed aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine esters with α-angelicalactone.

Graphical abstract: Visible light-induced aerobic oxidative cross-coupling of glycine esters with α-angelicalactone: a facile pathway to γ-lactams
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Enantioselective biocatalytic formal α-amination of hexanoic acid to L-norleucine

A three-step one-pot biocatalytic cascade enabled the enantioselective formal α-amination of hexanoic acid to L-norleucine in >97% ee.

Graphical abstract: Enantioselective biocatalytic formal α-amination of hexanoic acid to l-norleucine
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Cobalt(II)-catalyzed regioselective C–H halogenation of anilides

A cobalt-catalyzed regioselective C–H halogenation methodology is reported herein.

Graphical abstract: Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent developments in photochemical reactions of diazo compounds

Chemistry of diazo compounds is dominated by transition metal catalysis but recently, photoinitiated reactions of diazo compounds have attracted a lot of attention. This mini-review describes recent discoveries on the reactivity of diazo compounds under light irradiation.

Graphical abstract: Recent developments in photochemical reactions of diazo compounds
From the themed collection: Synthetic methodology in OBC
Paper

Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene

First enzymatic syntheses of triterpenes bearing a 7-oxabicyclo[2.2.1]heptane moiety and a novel scaffold, named neogammacerane, by the mutated cyclases.

Graphical abstract: Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams

Enabled by nickel catalysis, the first radical tandem cyclization–arylation for the synthesis of 4-benzyl-3,3-difluoro-γ-lactams has been developed.

Graphical abstract: Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Chiral benzazaboroles as catalysts for enantioselective sulfonylation of cis-1,2-diols

Chiral benzazaboroles that function as catalysts for enantioselective reactions were developed.

Graphical abstract: Chiral benzazaboroles as catalysts for enantioselective sulfonylation of cis-1,2-diols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Stereoselective synthesis of chromane derivatives via a domino reaction catalyzed by modularly designed organocatalysts

A highly enantio- and diastereoselective synthesis of functionalized chroman-2-ones and chromanes was achieved.

Graphical abstract: Stereoselective synthesis of chromane derivatives via a domino reaction catalyzed by modularly designed organocatalysts
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

A highly enantioselective nucleophilic addition of ketones to versatile imines catalyzed by chiral PTC has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields and excellent enantioselectivities. This protocol is effective for gram scale reaction.

Graphical abstract: Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Reaction condition controlled nickel(II)-catalyzed C–C cross-coupling of alcohols

Nickel(II)-catalyzed C–C cross-coupling of secondary and primary alcohols selectively produced β-alkylated secondary alcohols, α-alkylated ketones and α,β-unsaturated ketones.

Graphical abstract: Reaction condition controlled nickel(ii)-catalyzed C–C cross-coupling of alcohols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

A novel polystyrene-supported diphenylamine-linked bis(oxazoline) complex was developed for asymmetric fluorination in continuous flow, showing high activity and excellent enantioselectivity with a high turnover number.

Graphical abstract: Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of topologically constrained naphthalimide appended palladium(II)–N-heterocyclic carbene complexes – insights into additive controlled product selectivity

Pd(II)–NHC catalyzed regioselective heteroannulation of o-haloanilines and arylethynyl-trimethylsilane to yield indoles and additive controlled switchable product selectivity has been demonstrated.

Graphical abstract: Synthesis of topologically constrained naphthalimide appended palladium(ii)–N-heterocyclic carbene complexes – insights into additive controlled product selectivity
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

N-Alkyl amide synthesis via N-alkylation of amides with alcohols

The present review summarizes the recent development of N-alkylation of amides with alcohols according to the classification of catalysts.

Graphical abstract: N-Alkyl amide synthesis via N-alkylation of amides with alcohols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives

The highly enantioselective Strecker reaction with alpha-perfluoroalkylated cyclic ketimines was reported. The corresponding asymmetric cyclic nitriles are a useful tool for obtaining amino acids and their derivatives.

Graphical abstract: Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives
From the themed collection: Catalysis & biocatalysis in OBC
Paper

High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones

A highly enantioselective and relatively fast (1–5 h) Michael reaction with substantial reduction of organocatalyst loading (0.2–1 mol%) was developed under high-pressure conditions (up to 9 kbar) and at room temperature.

Graphical abstract: High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Aromatic donor–acceptor interaction promoted catalyst assemblies for hydrolytic kinetic resolution of epichlorohydrin

The catalyst activity of bis-acceptor functionalized Co(III)–salen in hydrolytic kinetic resolution can be fine-tuned by introducing a proper donor compound.

Graphical abstract: Aromatic donor–acceptor interaction promoted catalyst assemblies for hydrolytic kinetic resolution of epichlorohydrin
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Gold(I)-catalysed high-yielding synthesis of indenes by direct Csp3–H bond activation

A catalytic, practical and high-yielding procedure for the synthesis of indenes by direct Csp3–H activation under gold(I) catalysis was developed.

Graphical abstract: Gold(i)-catalysed high-yielding synthesis of indenes by direct Csp3–H bond activation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor

The reduction of aromatic nitriles to aldehydes is performed with good to excellent yields and selectivities. Calcium hypophosphite is used in the presence of nickel(II) catalyst and base in a water/ethanol system.

Graphical abstract: Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design

Conduct structure-guided modification on the “hotspot” of glycosyltransferase UGTBL1 to significantly adjust its regioselectivity toward polydatin production.

Graphical abstract: Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design
From the themed collection: Catalysis & biocatalysis in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to catalysis and biocatalysis research.

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