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Themed collection Catalysis & biocatalysis in OBC

101 items - Showing page 1 of 2
Accepted Manuscript - Review Article

Recent developments in photochemical reactions of diazo compounds

From the themed collection: Carbenes in Organic Synthesis
Review Article

Beyond the traditional roles of Ag in catalysis: the transmetalating ability of organosilver(I) species in Pd-catalysed reactions

The role of silver salts in Pd-catalysed C–C bond forming transformations.

Graphical abstract: Beyond the traditional roles of Ag in catalysis: the transmetalating ability of organosilver(i) species in Pd-catalysed reactions
From the themed collection: New Talent
Review Article

The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions

Factors that affect the efficiency of amine transaminase catalyzed reactions using isopropylamine as an amine donor.

Graphical abstract: The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions.

Graphical abstract: The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Indium(III) as π-acid catalyst for the electrophilic activation of carbon–carbon unsaturated systems

This review focuses on indium(III) as a π-acid for the activation of C–C unsaturated systems (alkynes, alkenes, and allenes) in organic synthesis.

Graphical abstract: Indium(iii) as π-acid catalyst for the electrophilic activation of carbon–carbon unsaturated systems
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Dibenzofuran-4,6-bis(oxazoline) (DBFOX). A novel trans-chelating bis(oxazoline) ligand for asymmetric reactions

The trans-chelating bis(oxazoline) ligand (R,R)-4,6-dibenzofurandiyl-2,2′-bis(4-phenyloxazoline) [(R,R)-DBFOX/Ph] coordinates metal ions to give C2-symmetric complexes which effectively catalyze a variety of asymmetric reactions.

Graphical abstract: Dibenzofuran-4,6-bis(oxazoline) (DBFOX). A novel trans-chelating bis(oxazoline) ligand for asymmetric reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Asymmetric iodine catalysis-mediated enantioselective oxidative transformations

The implementation of chiral iodine catalysis has tremendously been developed in the field of asymmetric synthesis over the past decade.

Graphical abstract: Asymmetric iodine catalysis-mediated enantioselective oxidative transformations
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Development and application of chiral spirocyclic phosphoric acids in asymmetric catalysis

This review describes the synthetic methods for the preparation of chiral spirocyclic phosphoric acids (SPAs), and their dynamically developing application for catalytic enantioselective transformations.

Graphical abstract: Development and application of chiral spirocyclic phosphoric acids in asymmetric catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Halo-substituted benzenesulfonyls and benzenesulfinates: convenient sources of arenes in metal-catalyzed C–C bond formation reactions for the straightforward access to halo-substituted arenes

The use of halo-substituted ArSO2R as an aryl source in metal-catalyzed C–C bond formation reactions presents several advantages, as the reaction often proceeds without cleavage of the C–halo bonds.

Graphical abstract: Halo-substituted benzenesulfonyls and benzenesulfinates: convenient sources of arenes in metal-catalyzed C–C bond formation reactions for the straightforward access to halo-substituted arenes
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Chiral proton-transfer shuttle catalysts for carbene insertion reactions

The development of chiral proton-transfer shuttles provides a totally new enantiocontrol strategy for transition metal-catalyzed asymmetric carbene insertion reactions.

Graphical abstract: Chiral proton-transfer shuttle catalysts for carbene insertion reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent advances in iodine mediated electrochemical oxidative cross-coupling

This review article gives an overview of the recent development of iodine mediated electrochemical oxidative coupling reactions.

Graphical abstract: Recent advances in iodine mediated electrochemical oxidative cross-coupling
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Catalytic asymmetric enamine protonation reaction

Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review.

Graphical abstract: Catalytic asymmetric enamine protonation reaction
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Review Article

Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors

Terpenoid structural diversity is enhanced by multiproduct enzymes. Biosynthesis can be altered by switch in substrates, cofactors and pH.

Graphical abstract: Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation

Hydrosilylation of imines was achieved using a redox non-innocent Fe-BIAN catalyst and employing the inexpensive trialkoxysilane (EtO)3SiH.

Graphical abstract: Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Organocatalytic asymmetric synthesis of highly substituted pyrrolidines bearing a stereogenic quaternary centre at the 3-position

An organocatalytic asymmetric cascade reaction has been developed between N-tosyl aminomethyl enones and trans-α-cyano-α,β-unsaturated ketones for the synthesis of highly substituted pyrrolidines having a stereogenic quaternary centre at the 3-position.

Graphical abstract: Organocatalytic asymmetric synthesis of highly substituted pyrrolidines bearing a stereogenic quaternary centre at the 3-position
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed arene amination in pure aqueous ammonia

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed.

Graphical abstract: Copper-catalyzed arene amination in pure aqueous ammonia
From the themed collection: New Talent
Communication

Direct enantio- and diastereoselective Mannich reactions of isatin-derived ketimines with oxo-indanecarboxylates catalyzed by chiral thiourea derived from hydroquinidine

A series of 3-substituted 3-amino-oxindoles were constructed by this protocol in excellent yields (92–99%) with high enantioselectivities (85–99% ee) and diastereoselectivities (up to >99 : 1 dr).

Graphical abstract: Direct enantio- and diastereoselective Mannich reactions of isatin-derived ketimines with oxo-indanecarboxylates catalyzed by chiral thiourea derived from hydroquinidine
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

A highly enantioselective nucleophilic addition of ketones to versatile imines catalyzed by chiral PTC has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields and excellent enantioselectivities. This protocol is effective for gram scale reaction.

Graphical abstract: Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Base-catalyzed selective esterification of alcohols with unactivated esters

tert-Butyl esters were identified as efficient esterification reagents for base-catalyzed esterification reactions, and mechanistic studies provided evidence of an exchange of the tert-butyl alkoxide metal with alcohol.

Graphical abstract: Base-catalyzed selective esterification of alcohols with unactivated esters
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes

A simple and efficient iron-catalyzed protodehalogenation of alkyl and aryl halides using phenylhydrosilane is disclosed.

Graphical abstract: Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes

Simple cationic bis(phosphine)iridium complexes are shown to be highly selective catalysts for ether cleavage with silanes. Benzylic ethers can be cleaved under mild conditions in the presence of reductively-labile functional groups.

Graphical abstract: Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Direct synthesis of indenes via a rhodium-catalyzed multicomponent Csp2–H annulation reaction

A highly efficient, direct and multicomponent route for the synthesis of indenes is reported herein.

Graphical abstract: Direct synthesis of indenes via a rhodium-catalyzed multicomponent Csp2–H annulation reaction
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Enantioselective biocatalytic formal α-amination of hexanoic acid to L-norleucine

A three-step one-pot biocatalytic cascade enabled the enantioselective formal α-amination of hexanoic acid to L-norleucine in >97% ee.

Graphical abstract: Enantioselective biocatalytic formal α-amination of hexanoic acid to l-norleucine
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines

A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope.

Graphical abstract: Iron(iii)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Palladium-catalyzed heck-type cascade cyclization of (Z)-1-iodo-1,6-dienes with N-tosyl hydrazones

A new way to synthesize tetrahydropyridine derivatives bearing a terminal alkene due to highly regioselective β-H elimination of alkylpalladium species.

Graphical abstract: Palladium-catalyzed heck-type cascade cyclization of (Z)-1-iodo-1,6-dienes with N-tosyl hydrazones
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Gold(I)-catalysed high-yielding synthesis of indenes by direct Csp3–H bond activation

A catalytic, practical and high-yielding procedure for the synthesis of indenes by direct Csp3–H activation under gold(I) catalysis was developed.

Graphical abstract: Gold(i)-catalysed high-yielding synthesis of indenes by direct Csp3–H bond activation
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate

Visible-light induced perfluoroalkylation of the α-position of aldehydes via enamines.

Graphical abstract: Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate
From the themed collection: Synthetic methodology in OBC
Communication

Rhodium(III)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation

An efficient procedure for 6H-benzo[c]chromenes via a new Rh(III)-catalyzed domino annulation is described.

Graphical abstract: Rhodium(iii)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation
From the themed collection: Synthetic methodology in OBC
Communication

Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols

An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between (E)-2-(2-nitrovinyl)phenols and 1,3-propanediones is disclosed to generate products having keto, ester and nitro functionalities.

Graphical abstract: Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

A nickel catalyzed C–H bond functionalization reaction has been used for the first time to study an intramolecular site-selective C–S bond formation of arenes.

Graphical abstract: Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes

A new chiral monodentate spiro phosphoramidite ligand based on a hexamethyl-1,1′-spirobiindane scaffold has been developed and applied in Pd-catalyzed asymmetric hydroamination/arylation of alkenes.

Graphical abstract: Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones

An organocatalytic asymmetric Mannich reaction between 3-cyano-3,4-dihydroquinolones and amidosulfones has been developed to construct biologically important 3,3-disubstituted 3,4-dihydroquinolones.

Graphical abstract: An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones
From the themed collection: Catalysis & biocatalysis in OBC
Communication

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed.

Graphical abstract: A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions

A nucleophilic catalyst is introduced for facile radical formation and its catalyst controlled aerobic oxidation.

Graphical abstract: An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates

An electrochemical Hofmann rearrangement is reported, which provides general and practical access to bioactive carbamates.

Graphical abstract: Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Cobalt-catalyzed carbon–sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines

An efficient cobalt-catalyzed C–S/C–Se bond formation method for the synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines has been developed.

Graphical abstract: Cobalt-catalyzed carbon–sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines

The application of bifunctional catalysis for the synthesis of tetrahydro-1,2-oxazines is described.

Graphical abstract: Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Rh(III)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature

Directing group ONHR preserved ortho-alkynylation under mild conditions catalyzed by rhodium is reported.

Graphical abstract: Rh(iii)-Catalyzed ortho-C–H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature
From the themed collection: Catalysis & biocatalysis in OBC
Communication

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones

A novel phosphine-catalyzed umpolung [3 + 2]-annulative dimerization of ynones was developed to furnish functionally rich 5-alkylidene-2-cyclopentenones.

Graphical abstract: Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Visible light promoted coupling of alkynyl bromides and Hantzsch esters for the synthesis of internal alkynes

A metal-free visible light promoted synthesis of internal alkynes was developed via the C(sp3)–C(sp) coupling of alkynyl bromides and Hantzsch esters.

Graphical abstract: Visible light promoted coupling of alkynyl bromides and Hantzsch esters for the synthesis of internal alkynes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Aromatic donor–acceptor interaction promoted catalyst assemblies for hydrolytic kinetic resolution of epichlorohydrin

The catalyst activity of bis-acceptor functionalized Co(III)–salen in hydrolytic kinetic resolution can be fine-tuned by introducing a proper donor compound.

Graphical abstract: Aromatic donor–acceptor interaction promoted catalyst assemblies for hydrolytic kinetic resolution of epichlorohydrin
From the themed collection: Catalysis & biocatalysis in OBC
Accepted Manuscript - Paper

Cu–Catalyzed Carbamoylation versus Amination of Quinoline N–Oxide with Formamides

From the themed collection: Catalysis & biocatalysis in OBC
Paper

Stereoselective synthesis of chromane derivatives via a domino reaction catalyzed by modularly designed organocatalysts

A highly enantio- and diastereoselective synthesis of functionalized chroman-2-ones and chromanes was achieved.

Graphical abstract: Stereoselective synthesis of chromane derivatives via a domino reaction catalyzed by modularly designed organocatalysts
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Anthracene–rhodium complexes with metal coordination at the central ring – a new class of catalysts for reductive amination

A new class of anthracene–metal complexes with central ring coordination was tested in catalysis. A simple and efficient protocol for reductive amination without an external hydrogen source has been developed.

Graphical abstract: Anthracene–rhodium complexes with metal coordination at the central ring – a new class of catalysts for reductive amination
From the themed collection: Catalysis & biocatalysis in OBC
Paper

B(C6F5)3-catalyzed Markovnikov addition of indoles to aryl alkynes: an approach toward bis(indolyl)alkanes

The B(C6F5)3-catalyzed Markovnikov addition of indoles to aryl alkynes was achieved, leading to a wide spectrum of versatile bis(indolyl)alkanes in moderate to good yields with high regioselectivities.

Graphical abstract: B(C6F5)3-catalyzed Markovnikov addition of indoles to aryl alkynes: an approach toward bis(indolyl)alkanes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of 2-substituted benzo[b]thiophenes via gold(I)–NHC-catalyzed cyclization of 2-alkynyl thioanisoles

Efficient synthesis of benzo[b]thiophenes from 2-alkynyl thioanisoles catalyzed by a gold(I)–IPr hydroxide and co-catalyzed by acetic acid.

Graphical abstract: Synthesis of 2-substituted benzo[b]thiophenes via gold(i)–NHC-catalyzed cyclization of 2-alkynyl thioanisoles
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Copper-catalyzed synthesis of 2,2,2-trifluoroethyl selenoethers and their insecticidal activities

A copper-catalyzed synthesis of aryl or alkyl 2,2,2-trifluoroethyl selenoethers was developed. Some of them exhibited promising insecticidal activities against tetranychus cinnabarinus.

Graphical abstract: Copper-catalyzed synthesis of 2,2,2-trifluoroethyl selenoethers and their insecticidal activities
From the themed collection: Catalysis & biocatalysis in OBC
Paper

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism

PKS dehydratases utilize a one-base mechanism.

Graphical abstract: pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism
From the themed collection: Catalysis & biocatalysis in OBC
Accepted Manuscript - Paper

Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes

From the themed collection: Catalysis & biocatalysis in OBC
Accepted Manuscript - Paper

Synthesis of quinazoline-3-oxides via Pd(II) catalyzed azide-isocyanide coupling/cyclocondensation reaction

From the themed collection: Catalysis & biocatalysis in OBC
Paper

N,O-Bidentate ligand-tunable copper(II) complexes as a catalyst for Chan–Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives

Four novel N,O-bidentate ligand-tunable copper complexes were developed as a catalyst for Chan–Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives under base-free conditions.

Graphical abstract: N,O-Bidentate ligand-tunable copper(ii) complexes as a catalyst for Chan–Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives
From the themed collection: Synthetic methodology in OBC
Paper

Aerobic oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid and its derivatives by heterogeneous NHC-catalysis

Heterogeneous NHC-catalysis is an effective synthetic platform for the production of bio-based furan derivatives.

Graphical abstract: Aerobic oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid and its derivatives by heterogeneous NHC-catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Various chiral seven-membered β-substituted lactams were successfully prepared through Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation with up to >99% conversion, 99% yield, and >99% ee.

Graphical abstract: Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases

Xyloglucan (XyG) is a complex polysaccharide that is ubiquitous and often abundant in the cell walls of terrestrial plants.

Graphical abstract: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Visible light-promoted difluoromethylthiolation of aryldiazonium salts

Difluoromethylthiolation of aryldiazonium salts under mild conditions using a shelf-stable reagent (PhSO2SCF2H) was reported.

Graphical abstract: Visible light-promoted difluoromethylthiolation of aryldiazonium salts
From the themed collection: Synthetic methodology in OBC
Paper

Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts

An efficient C2-symmetric bifunctional tertiary amine–squaramide organocatalyst for the asymmetric Michael addition/hemiketalization domino reaction of kojic acid derivatives with β,γ-unsaturated α-ketoesters has been designed.

Graphical abstract: Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds

Rhodium(III)-catalyzed alkylation reactions of arenes through triazole directed C–H activation that lead to a number of dialkylated and monoalkylated triazoles are described.

Graphical abstract: Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Manganese catalyzed N-alkylation of anilines with alcohols: ligand enabled selectivity

Ligand enabled earth-abundant manganese catalyzed N-alkylation of amines with alcohols via a hydrogen auto-transfer strategy is reported. The choice of the ligand plays a significant role in the alcohol reactivity (aliphatic or aromatic) toward N-alkylation reactions.

Graphical abstract: Manganese catalyzed N-alkylation of anilines with alcohols: ligand enabled selectivity
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of medium-sized (6–7–6) ring compounds by iron-catalyzed dehydrogenative C–H activation/annulation

Iron-catalyzed synthesis of fused seven-membered ring compounds by intramolecular hydroarylation of alkynes.

Graphical abstract: Synthesis of medium-sized (6–7–6) ring compounds by iron-catalyzed dehydrogenative C–H activation/annulation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Synthesis of highly rigid phosphine–oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

Rigid phosphine–oxazoline ligands with a spirocarbon stereogenic center were developed, which exhibited excellent catalytic performance for Pd-catalyzed allylic alkylation reactions.

Graphical abstract: Synthesis of highly rigid phosphine–oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

A novel polystyrene-supported diphenylamine-linked bis(oxazoline) complex was developed for asymmetric fluorination in continuous flow, showing high activity and excellent enantioselectivity with a high turnover number.

Graphical abstract: Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Formal reductive addition of acetonitrile to aldehydes and ketones

Aldehydes and ketones can be converted to nitriles with two extra carbons in one step with TON up to 5600.

Graphical abstract: Formal reductive addition of acetonitrile to aldehydes and ketones
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase

Structure-guided molecular modelling and site-directed mutagenesis of the tryptophan dimethylallyl transferase FgaPT2 led to creation of mutants with strongly enhanced activities towards geranyl and farnesyl diphosphates.

Graphical abstract: Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Dirhodium(II)/P(t-Bu)3 catalyzed tandem reaction of α,β-unsaturated aldehydes with arylboronic acids

Axially alkylphosphane ligated Rh2(OAc)4 catalyzes the tandem reaction of α,β-unsaturated aldehydes with arylboronic acids to produce ketone derivatives in high yields.

Graphical abstract: Dirhodium(ii)/P(t-Bu)3 catalyzed tandem reaction of α,β-unsaturated aldehydes with arylboronic acids
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles

Ru(II)-NHC catalyzes α-olefination of 2-oxindole via dehydrogenative coupling of 2-oxindole and diaryl methanol to generate selectively antimalarial 3-(diphenylmethylene)indolin-2-one derivatives.

Graphical abstract: Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles
From the themed collection: Synthetic methodology in OBC
Paper

Organocatalysis and catalyst aggregation: a study using the asymmetric synthesis of benzofuranones as a test reaction

An aggregation phenomenon involving Cinchona alkaloid derivatives deeply affects the performance of the catalyst in an organocatalytic process – a mechanistic study.

Graphical abstract: Organocatalysis and catalyst aggregation: a study using the asymmetric synthesis of benzofuranones as a test reaction
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives

The highly enantioselective Strecker reaction with alpha-perfluoroalkylated cyclic ketimines was reported. The corresponding asymmetric cyclic nitriles are a useful tool for obtaining amino acids and their derivatives.

Graphical abstract: Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols

A boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols as nucleophiles has been accomplished.

Graphical abstract: Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene

First enzymatic syntheses of triterpenes bearing a 7-oxabicyclo[2.2.1]heptane moiety and a novel scaffold, named neogammacerane, by the mutated cyclases.

Graphical abstract: Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene
From the themed collection: Catalysis & biocatalysis in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to catalysis and biocatalysis research.

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