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Issue 6, 2020
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Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

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Abstract

This review highlights the different enantioselective catalyst-controlled cascades creating multiple alcohol functions through the formation of several carbon–carbon bonds. Through subsequent simple derivatization, these strategies ensure the rapid preparation of 1,3-polyols. Thanks to the use of efficient metal- or organo-catalysts, these cascades enable the selective assembly of multiple substrates considerably limiting operations and waste generation. For this purpose, several mono- or bi-directional approaches have been devised allowing successive C–C bond-forming events. The considerable synthetic economies these cascades enable have been demonstrated in the preparation of a wide variety of complex bioactive natural products, notably polyketides.

Graphical abstract: Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

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Article information


Submitted
17 Dec 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

This article is Open Access

Org. Biomol. Chem., 2020,18, 1025-1035
Article type
Review Article

Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

C. Sperandio, J. Rodriguez and A. Quintard, Org. Biomol. Chem., 2020, 18, 1025
DOI: 10.1039/C9OB02675D

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