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Issue 25, 2019
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Chiral palladium pincer complexes for asymmetric catalytic reactions

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Abstract

Palladium pincer complexes, containing a monoanionic terdentate ligand composed of an anionic aryl carbon atom and two mutually compatible donor sites, have aroused considerable interest since their first reports in the late 1970s. The high stability of the Pd pincer complexes and particularly their high modularity make these species ideal candidates for catalysis. Furthermore, the nature of the meridional coordination of the pincer ligands, and along with this their ability to enforce a stereo-specific environment around the Pd center, provide a good opportunity for developing chiral Pd pincer catalysts. Thus, a broad variety of chiral Pd pincer complexes have been prepared by the introduction of various stereochemical centers in the pincer skeletons. These chiral Pd pincer complexes have been successfully applied to many asymmetric catalytic reactions such as hydrophosphination reactions, allylation of aldehydes and imines, Michael and aldol reactions, Suzuki–Miyaura reactions as well as reactions of nitrile compounds with imines. This review focuses on the synthetic methods and the applications of chiral Pd pincer complexes in asymmetric catalysis.

Graphical abstract: Chiral palladium pincer complexes for asymmetric catalytic reactions

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Article information


Submitted
18 Feb 2019
Accepted
07 May 2019
First published
07 May 2019

Org. Biomol. Chem., 2019,17, 6069-6098
Article type
Review Article

Chiral palladium pincer complexes for asymmetric catalytic reactions

J. Liu, J. Gong and M. Song, Org. Biomol. Chem., 2019, 17, 6069
DOI: 10.1039/C9OB00401G

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