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Recent trends in catalytic sp3 C–H functionalization of heterocycles

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Abstract

Heterocycles are a ubiquitous substructure in organic small molecules designed for use in materials and medicines. Recent work in catalysis has focused on enabling access to new heterocycle structures by sp3 C–H functionalization on alkyl side-chain substituents—especially at the heterobenzylic position—with more than two hundred manuscripts published just within the last ten years. Rather than describing in detail each of these reports, in this mini-review we attempt to highlight gaps in existing techniques. A semi-quantitative overview of ongoing work strongly suggests that several specific heterocycle types and bond formations outside of C–C, C–N, and C–O have been almost completely overlooked.

Graphical abstract: Recent trends in catalytic sp3 C–H functionalization of heterocycles

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Supplementary files

Article information


Submitted
12 Jul 2019
Accepted
18 Sep 2019
First published
08 Jan 2020

This article is Open Access

Org. Biomol. Chem., 2020, Advance Article
Article type
Review Article

Recent trends in catalytic sp3 C–H functionalization of heterocycles

M. Kaur and J. F. Van Humbeck, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB01559K

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