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Issue 39, 2020
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Recent advances in catalytic enantioselective multicomponent reactions

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Abstract

Multicomponent reactions (MCRs) undoubtedly correspond to one of the synthetic strategies that best fit the new demands of chemistry for presenting high atom economy and enabling molecular diversity. However, many challenges still exist when products possessing stereogenic centres are formed. The field of asymmetric catalytic reactions has achieved significant progress in recent decades; new applications for chiral ligands and catalysts have been demonstrated and new catalysts have been specifically designed for challenging chemical conversions. In this sense, highly efficient approaches for classic multicomponent reactions such as the Ugi reaction and a number of new asymmetric MCRs have been described. In this review we discuss the recent developments that enable catalytic enantioselective MCRs including the proposed mechanistic pathways.

Graphical abstract: Recent advances in catalytic enantioselective multicomponent reactions

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Article information


Submitted
06 Aug 2020
Accepted
03 Sep 2020
First published
03 Sep 2020

Org. Biomol. Chem., 2020,18, 7751-7773
Article type
Review Article

Recent advances in catalytic enantioselective multicomponent reactions

P. S. G. Nunes, H. D. A. Vidal and A. G. Corrêa, Org. Biomol. Chem., 2020, 18, 7751
DOI: 10.1039/D0OB01631D

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