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Issue 30, 2019
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Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

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Abstract

This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C–H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very exciting research line. In particular, the development of proteins with the ability to perform C–H functionalization presents a significant challenge. Here we discuss the development of these processes on natural metalloenzymes by using directed evolution, biotin-(strept)avidin technologies, photocatalytic hybrids or reconstitution of heme-protein technology.

Graphical abstract: Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

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Article information


Submitted
10 May 2019
Accepted
03 Jul 2019
First published
04 Jul 2019

This article is Open Access

Org. Biomol. Chem., 2019,17, 7114-7123
Article type
Review Article

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

C. Perez-Rizquez, A. Rodriguez-Otero and J. M. Palomo, Org. Biomol. Chem., 2019, 17, 7114
DOI: 10.1039/C9OB01091B

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