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The roles of Lewis acidic additives in organotransition metal catalysis

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Abstract

We describe recent examples of prominent reactions in organic synthesis that involve transition metal and Lewis acid cocatalysts. Introducing Lewis acid additives to transition metal catalysis can enable new reactivity or improve activity and selectivity of an existing process. Several studies are highlighted to illustrate the possible roles of Lewis acids in catalytic mechanisms. The uses of Lewis acid additives in bond-breaking catalysis (C–C activation, C–H activation, and hydrogenolysis reactions) and bond-forming catalysis (Au-catalysed alkyne functionalisation, Pd-catalysed C–C and C–N bond formation) are reviewed.

Graphical abstract: The roles of Lewis acidic additives in organotransition metal catalysis

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Publication details

The article was received on 15 Nov 2018, accepted on 14 Jan 2019 and first published on 22 Jan 2019


Article type: Review Article
DOI: 10.1039/C8OB02856G
Citation: Org. Biomol. Chem., 2019, Advance Article

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    The roles of Lewis acidic additives in organotransition metal catalysis

    J. Becica and G. E. Dobereiner, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02856G

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