Jump to main content
Jump to site search

Themed collection Recent Advances in Flow Synthesis and Continuous Processing

24 items
Open Access Feature Article

Fouling in microstructured devices: a review

This work reviews efforts in the greatest challenge to operate microsystems: fouling and blocking.

Graphical abstract: Fouling in microstructured devices: a review
Feature Article

Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Despite all the organic chemistry reaction methodologies already developed for the continuous-flow process, asymmetric synthesis is one that has gained less attention.

Graphical abstract: Expanding the toolbox of asymmetric organocatalysis by continuous-flow process
Feature Article

The utilization of copper flow reactors in organic synthesis

A review which highlights the current research employing copper-metal flow reactors in bench-top organic synthesis.

Graphical abstract: The utilization of copper flow reactors in organic synthesis
Feature Article

Flash chemistry: flow chemistry that cannot be done in batch

Flash chemistry based on high-resolution reaction time control using flow microreactors enables chemical transformations that cannot be done in batch.

Graphical abstract: Flash chemistry: flow chemistry that cannot be done in batch
Review Article

Subtle Mitsunobu couplings under super-heating: the role of high-throughput continuous flow and microwave strategies

Fragile Mitsunobu reaction can efficiently be performed under super-heating.

Graphical abstract: Subtle Mitsunobu couplings under super-heating: the role of high-throughput continuous flow and microwave strategies
Communication

Watching polymers grow: real time monitoring of polymerizations via an on-line ESI-MS/microreactor coupling

A microreactor/electrospray ionization MS coupling is introduced that allows us to observe and optimize polymerization reactions with respect to chain length and endgroup patterns in real time under synthesis conditions, which was not possible before.

Graphical abstract: Watching polymers grow: real time monitoring of polymerizations via an on-line ESI-MS/microreactor coupling
Open Access Communication

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.

Graphical abstract: Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives
Communication

Microfluidic supercritical antisolvent continuous processing and direct spray-coating of poly(3-hexylthiophene) nanoparticles for OFET devices

We report for the first time the use of a microfluidic supercritical antisolvent process (μSAS) to synthesize semiconducting polymer nanoparticles (NPs) of poly(3-hexylthiophene) (P3HT).

Graphical abstract: Microfluidic supercritical antisolvent continuous processing and direct spray-coating of poly(3-hexylthiophene) nanoparticles for OFET devices
Communication

Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents

A custom-built modular flow reactor featuring immobilized reagents in exchangeable cartridges has been developed.

Graphical abstract: Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents
Communication

The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

An efficient nitro-Mannich type direct α-C(sp3)–H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described.

Graphical abstract: The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing
Communication

Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

Flash chemistry enabled generation and reactions of short-lived α-(trifluoromethyl)vinyllithium, and the method was successfully applied to three-component synthesis of α-trifluoromethylamides.

Graphical abstract: Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides
Communication

Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

Preparation of amides from low nucleophilic heterocyclic amines is achieved in 2 minutes under mild conditions.

Graphical abstract: Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions
Open Access Communication

Continuous synthesis of artemisinin-derived medicines

Continuous, convergent/divergent synthesis of four anti-malarial APIs.

Graphical abstract: Continuous synthesis of artemisinin-derived medicines
Communication

Continuous flow synthesis of β-amino acids from α-amino acids via Arndt–Eistert homologation

A fully continuous four step process for the preparation of β-amino acids from their corresponding α-amino acids utilizing the Arndt–Eistert homologation approach is described.

Graphical abstract: Continuous flow synthesis of β-amino acids from α-amino acids via Arndt–Eistert homologation
Communication

Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip

We present a microfluidic device integrating continuous flow reactions and separations on a single chip.

Graphical abstract: Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip
Communication

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

We have developed a rapid and automated microfluidic flow hydrogenation method as a viable tool for reducing functional groups and deprotection in the synthesis of PET radiotracers.

Graphical abstract: Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds
Open Access Paper

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

The efficient flow synthesis of important heterocyclic building blocks based on the 1,2,4-triazole and pyrrolo[1,2-c]pyrimidine scaffold has been achieved.

Graphical abstract: Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines
Paper

A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions

A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones under continuous flow conditions.

Graphical abstract: A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions
Paper

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor.

Graphical abstract: A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions
Open Access Paper

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

A flow process to access oxazolines and oxazoles via a rapid and practical protocol is described.

Graphical abstract: The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
Paper

An efficient continuous flow approach to furnish furan-based biaryls

Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N+F and the immobilised t-butyl based palladium catalyst CatCart™ FC1032™.

Graphical abstract: An efficient continuous flow approach to furnish furan-based biaryls
Paper

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions.

Graphical abstract: Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization
Open Access Paper

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

Towards a continuous synthesis of the HIV protease inhibitor Atazanavir a key building block is prepared in a three step sequence.

Graphical abstract: A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir
Paper

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

A flow based synthesis of imatinib and analogues requiring minimal manual intervention.

Graphical abstract: An expeditious synthesis of imatinib and analogues utilising flow chemistry methods
24 items

About this collection

This themed collection published across ChemComm and Organic & Biomolecular Chemistry (OBC) highlights some of the latest exciting research in flow synthesis and continuous processing. The issue is Guest Edited by Professors Ian Baxendale and Jun-ichi Yoshida. New articles will be added to this collection as they are published.

Spotlight

Advertisements