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Issue 6, 2015
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Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

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Abstract

A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a membrane-based phase separation module. The wider applicability of our setup was demonstrated with the synthesis of nine protected cyanohydrin derivatives, all obtained in good yields and high to excellent enantioselectivity.

Graphical abstract: Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

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Publication details

The article was received on 05 Oct 2014, accepted on 08 Dec 2014 and first published on 08 Dec 2014


Article type: Communication
DOI: 10.1039/C4OB02128B
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Citation: Org. Biomol. Chem., 2015,13, 1634-1638
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    Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

    M. M. E. Delville, K. Koch, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2015, 13, 1634
    DOI: 10.1039/C4OB02128B

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