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Issue 95, 2014
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Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

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Abstract

α-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at −78 °C in a flow microreactor although the batch reaction should be carried out at ca. −100 °C, and the method was applied to continuous flow three-component synthesis of α-trifluoromethylamides.

Graphical abstract: Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

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Article information


Submitted
26 Aug 2014
Accepted
06 Oct 2014
First published
21 Oct 2014

Chem. Commun., 2014,50, 15079-15081
Article type
Communication

Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

A. Nagaki, S. Tokuoka and J. Yoshida, Chem. Commun., 2014, 50, 15079
DOI: 10.1039/C4CC06709F

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