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Issue 2, 2015
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The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

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Abstract

An efficient nitro-Mannich type direct α-C(sp3)–H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.

Graphical abstract: The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

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Supplementary files

Article information


Submitted
10 Oct 2014
Accepted
07 Nov 2014
First published
14 Nov 2014

Chem. Commun., 2015,51, 334-337
Article type
Communication
Author version available

The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

M. Brzozowski, J. A. Forni, G. Paul Savage and A. Polyzos, Chem. Commun., 2015, 51, 334
DOI: 10.1039/C4CC07913B

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