Martin Brzozowski, Jose A. Forni, G. Paul Savage and Anastasios Polyzos
Chem. Commun., 2015,51, 334-337
DOI:
10.1039/C4CC07913B,
Communication
An efficient nitro-Mannich type direct α-C(sp3)–H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.
