The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions†
A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
- This article is part of the themed collection: Recent Advances in Flow Synthesis and Continuous Processing