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Issue 15, 2015
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The utilization of copper flow reactors in organic synthesis

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Abstract

The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reaction counterparts, in terms of both safety and yield. This review will highlight the current research employing copper flow reactors, such as 1,3-dipolar cycloadditions (‘click’ chemistry), macrocyclizations (via ‘click’ chemistry), Sonogashira C–C couplings, Ullmann couplings, decarboxylations, and other reported findings.

Graphical abstract: The utilization of copper flow reactors in organic synthesis

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Article information


Submitted
18 Nov 2014
Accepted
18 Dec 2014
First published
18 Dec 2014

Chem. Commun., 2015,51, 3037-3044
Article type
Feature Article
Author version available

The utilization of copper flow reactors in organic synthesis

J. Bao and G. K. Tranmer, Chem. Commun., 2015, 51, 3037
DOI: 10.1039/C4CC09221J

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