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Issue 11, 2013
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An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

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Abstract

A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of many of the reaction components.

Graphical abstract: An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

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Article information


Submitted
15 Oct 2012
Accepted
04 Dec 2012
First published
05 Dec 2012

Org. Biomol. Chem., 2013,11, 1822-1839
Article type
Paper

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

M. D. Hopkin, I. R. Baxendale and S. V. Ley, Org. Biomol. Chem., 2013, 11, 1822
DOI: 10.1039/C2OB27002A

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