Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

Abstract

α-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at −78 °C in a flow microreactor although the batch reaction should be carried out at ca. −100 °C, and the method was applied to continuous flow three-component synthesis of α-trifluoromethylamides.