Themed collection Recent Advances in Flow Synthesis and Continuous Processing
Fouling in microstructured devices: a review
This work reviews efforts in the greatest challenge to operate microsystems: fouling and blocking.
Expanding the toolbox of asymmetric organocatalysis by continuous-flow process
Despite all the organic chemistry reaction methodologies already developed for the continuous-flow process, asymmetric synthesis is one that has gained less attention.
The utilization of copper flow reactors in organic synthesis
A review which highlights the current research employing copper-metal flow reactors in bench-top organic synthesis.
Flash chemistry: flow chemistry that cannot be done in batch
Flash chemistry based on high-resolution reaction time control using flow microreactors enables chemical transformations that cannot be done in batch.
Subtle Mitsunobu couplings under super-heating: the role of high-throughput continuous flow and microwave strategies
Fragile Mitsunobu reaction can efficiently be performed under super-heating.
Watching polymers grow: real time monitoring of polymerizations via an on-line ESI-MS/microreactor coupling
A microreactor/electrospray ionization MS coupling is introduced that allows us to observe and optimize polymerization reactions with respect to chain length and endgroup patterns in real time under synthesis conditions, which was not possible before.
Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
Microfluidic supercritical antisolvent continuous processing and direct spray-coating of poly(3-hexylthiophene) nanoparticles for OFET devices
We report for the first time the use of a microfluidic supercritical antisolvent process (μSAS) to synthesize semiconducting polymer nanoparticles (NPs) of poly(3-hexylthiophene) (P3HT).
Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents
A custom-built modular flow reactor featuring immobilized reagents in exchangeable cartridges has been developed.
The direct α-C(sp3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing
An efficient nitro-Mannich type direct α-C(sp3)–H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O2 as the terminal oxidant is described.
Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides
Flash chemistry enabled generation and reactions of short-lived α-(trifluoromethyl)vinyllithium, and the method was successfully applied to three-component synthesis of α-trifluoromethylamides.
Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions
Preparation of amides from low nucleophilic heterocyclic amines is achieved in 2 minutes under mild conditions.
Continuous synthesis of artemisinin-derived medicines
Continuous, convergent/divergent synthesis of four anti-malarial APIs.
Continuous flow synthesis of β-amino acids from α-amino acids via Arndt–Eistert homologation
A fully continuous four step process for the preparation of β-amino acids from their corresponding α-amino acids utilizing the Arndt–Eistert homologation approach is described.
Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip
We present a microfluidic device integrating continuous flow reactions and separations on a single chip.
Rapid microfluidic flow
hydrogenation for reduction or deprotection of 18F-labeled compounds
We have developed a rapid and automated microfluidic flow hydrogenation method as a viable tool for reducing functional groups and deprotection in the synthesis of PET radiotracers.
Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines
The efficient flow synthesis of important heterocyclic building blocks based on the 1,2,4-triazole and pyrrolo[1,2-c]pyrimidine scaffold has been achieved.
A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions
A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones under continuous flow conditions.
A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions
An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor.
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
A flow process to access oxazolines and oxazoles via a rapid and practical protocol is described.
An efficient continuous flow approach to furnish furan-based biaryls
Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N+F− and the immobilised t-butyl based palladium catalyst CatCart™ FC1032™.
Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions.
A three step continuous flow synthesis of the biaryl unit of the
HIV protease inhibitor Atazanavir
Towards a continuous synthesis of the HIV protease inhibitor Atazanavir a key building block is prepared in a three step sequence.
An expeditious synthesis of
imatinib and analogues utilising flow chemistry methods
A flow based synthesis of imatinib and analogues requiring minimal manual intervention.
About this collection
This themed collection published across ChemComm and Organic & Biomolecular Chemistry (OBC) highlights some of the latest exciting research in flow synthesis and continuous processing. The issue is Guest Edited by Professors Ian Baxendale and Jun-ichi Yoshida. New articles will be added to this collection as they are published.