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Themed collection Most popular 2018-2019 chemical biology articles

30 items
Open Access Perspective

Asking more from metabolic oligosaccharide engineering

Metabolic Oligosaccharide Engineering (MOE) is a groundbreaking strategy which has been largely used in the last decades, as a powerful strategy for glycans understanding. The present review aims to highlight recent studies that are pushing the boundaries of MOE applications.

Graphical abstract: Asking more from metabolic oligosaccharide engineering
Open Access Perspective

Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

We review pharmacological chaperones used in lysosomal storage diseases, emphasizing medicinal chemistry approaches and mechanisms of action.

Graphical abstract: Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
Open Access Minireview

Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo

Copper-free click chemistry has resulted in a change of paradigm, showing that artificial chemical reactions can occur on cell surfaces, in cell cytosol, or within the body. It has emerged as a valuable tool in biomedical fields.

Graphical abstract: Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo
Open Access Minireview

Mechanisms of catalytic reduction of CO2 with heme and nonheme metal complexes

This critical review discusses the thermal and photocatalytic mechanisms of one-, two-, four-, six- and eight-electron reduction of CO2 with metal complex catalysts.

Graphical abstract: Mechanisms of catalytic reduction of CO2 with heme and nonheme metal complexes
Open Access Minireview

Advances in targeting the folate receptor in the treatment/imaging of cancers

The folate receptor (FR) is an important biomarker for many cancers, and its overexpression on tumours can be exploited for targeted therapy, diagnosis and imaging.

Graphical abstract: Advances in targeting the folate receptor in the treatment/imaging of cancers
Open Access Edge Article

A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation

A novel upconversion nanoarchitecture is designed, whose 980 nm light photosensitized activity could be activated by 808 nm light.

Graphical abstract: A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation
Open Access Edge Article

Self-triggered click reaction in an Alzheimer's disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

Accumulated Cu in amyloid-β plaques can effectively catalyze the azide–alkyne cycloaddition reaction for fluorophore activation and drug synthesis. Our work may provide new insight into in situ drug synthesis for neurodegenerative diseases.

Graphical abstract: Self-triggered click reaction in an Alzheimer's disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques
Open Access Edge Article

Isomeric triazines exhibit unique profiles of bioorthogonal reactivity

Isomeric triazines can be tuned to exhibit unique reaction profiles with biocompatible strained alkenes and alkynes.

Graphical abstract: Isomeric triazines exhibit unique profiles of bioorthogonal reactivity
Open Access Edge Article

Designer artificial membrane binding proteins to direct stem cells to the myocardium

We present a new cell membrane modification methodology where the inherent heart tissue homing properties of the infectious bacteria Streptococcus gordonii are transferred to human stem cells.

Graphical abstract: Designer artificial membrane binding proteins to direct stem cells to the myocardium
Open Access Edge Article

RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery

The tumour switches on the NIR-AZA emission for fluorescence guided surgery.

Graphical abstract: RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy

A novel NIR-II theranostic nanoprobe, PSY (∼110 nm), was concisely developed, which demonstrated excellent photostability, high tumor uptake, superior S/N ratios and more efficient cancer treatment with minimal side effects than cisplatin.

Graphical abstract: A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(ii) metallacycle for efficient cancer imaging and therapy
Open Access Edge Article

Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

Drug-like, donor–acceptor diphenylacetylenes cause efficient cell death upon photoactivation and hence have potential phototherapeutic applications.

Graphical abstract: Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene
Open Access Edge Article

Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media.

Graphical abstract: Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Simultaneous dual-colour tracking lipid droplets and lysosomes dynamics using a fluorescent probe

NIM-7 is demonstrated to be a multicomponent fluorescent probe that accumulates in both lipid droplets and lysosomes after entering cells, giving rise to yellow and red fluorescence emission, respectively. This allows the two organelles to be visualized concurrently.

Graphical abstract: Simultaneous dual-colour tracking lipid droplets and lysosomes dynamics using a fluorescent probe
Open Access Edge Article

Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress

Dual-biomarker-triggered fluorescent probes were developed for simultaneous detection of the two biomarkers H2S and hNQO1 in cancer cells.

Graphical abstract: Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress
Open Access Edge Article

Fluorogenic hydrogen sulfide (H2S) donors based on sulfenyl thiocarbonates enable H2S tracking and quantification

Hydrogen sulfide (H2S) is an important cellular signaling molecule that exhibits promising protective effects.

Graphical abstract: Fluorogenic hydrogen sulfide (H2S) donors based on sulfenyl thiocarbonates enable H2S tracking and quantification
Open Access Edge Article

Selective C–H halogenation over hydroxylation by non-heme iron(IV)-oxo

Synthetic non-heme iron-oxo and iron-halide complexes promote selective halogenation of the sp3-C–H bonds via hydrogen atom abstraction and halide rebound phenomenon.

Graphical abstract: Selective C–H halogenation over hydroxylation by non-heme iron(iv)-oxo
Open Access Edge Article

ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy

Aptamer conjugated porphyrinic metal–organic framework (MOF) achieved target-induced bioimaging and photodynamic therapy.

Graphical abstract: ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
Open Access Edge Article

Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

A 1,8-naphthalimide-based two-photon fluorescent probe was designed to visualize MGO levels in living cells and a diabetic mice model.

Graphical abstract: Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe
Open Access Edge Article

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

Mining the genome to harvest from the metabolome: a well-directed search for bioactive natural products unearths the pyxidicyclines from Pyxidicoccus.

Graphical abstract: Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
Open Access Edge Article

Triple action Pt(IV) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

A series of triple action Pt(IV) prodrugs was designed to test the hypothesis that multi-action compounds, where each bioactive moiety intervenes in several cellular processes, might be more effective than a single agent at killing cancer cells.

Graphical abstract: Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance
Open Access Edge Article

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging

We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal decaging.

Graphical abstract: A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging
Open Access Edge Article

Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging

We report three synthetic methods to prepare biocompatible Yb3+ complexes, which displayed high NIR luminescence with quantum yields up to 13% in aqueous media. This renders β-fluorinated Yb3+ porphyrinoids a new class of NIR probes for living cell imaging including time-resolved fluorescence lifetime imaging.

Graphical abstract: Highly luminescent, biocompatible ytterbium(iii) complexes as near-infrared fluorophores for living cell imaging
Open Access Edge Article

Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues

Nanoscopy compatible fluorescent tubulin probes can be used to stain microtubules and chitin-rich taenidia in the insect tracheoles.

Graphical abstract: Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues
Open Access Edge Article

A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer.

Graphical abstract: A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy
Open Access Edge Article

Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process

Two AIEgens are designed for tracking mitochondria and lysosomes with different emission colors using single wavelength excitation to visualize the mitophagy process.

Graphical abstract: Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process
Open Access Edge Article

A chemiluminescent probe for cellular peroxynitrite using a self-immolative oxidative decarbonylation reaction

Peroxynitrite is a damaging agent of oxidative stress that has been difficult to monitor in living cells. Here, an isatin-based chemiluminescent probe for peroxynitrite is reported.

Graphical abstract: A chemiluminescent probe for cellular peroxynitrite using a self-immolative oxidative decarbonylation reaction
Open Access Edge Article

Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection

A PNA-templated peptide ligation reaction has been developed between selenocystine and selenoesters. The methodology was used for the sequence specific detection of miRNA at low concentrations.

Graphical abstract: Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection
Open Access Edge Article

Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box

Newly described NMR experimental approaches can provide valuable structural details and a complementary means of structure verification.

Graphical abstract: Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box
Open Access Edge Article

Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments

Enabling oriented installation of non-engineered antibody fragments on nanoparticle surfaces to create next-generation antibody–nanoparticle conjugates.

Graphical abstract: Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments
30 items

About this collection

This specially curated collection pulls together some of the most popular articles from 2018 and 2019 in the field of chemical biology. The collection presents some outstanding contributions to the field, ranging from dual-biomarker-triggered fluorescence probes for differentiating cancer cells to a review of the biomedical applications of copper-free click chemistry, and as with all Chemical Science articles - they are all completely free to access and read. We hope you enjoy browsing through this collection.

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