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Issue 9, 2019
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Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

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Abstract

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells.

Graphical abstract: Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

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Article information


Submitted
03 Oct 2018
Accepted
25 Dec 2018
First published
26 Dec 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 2598-2603
Article type
Edge Article

Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

P. Destito, A. Sousa-Castillo, J. R. Couceiro, F. López, M. A. Correa-Duarte and J. L. Mascareñas, Chem. Sci., 2019, 10, 2598 DOI: 10.1039/C8SC04390F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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