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Issue 17, 2019
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Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

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Abstract

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

Graphical abstract: Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

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Publication details

The article was received on 13 Jan 2019, accepted on 20 Mar 2019 and first published on 21 Mar 2019


Article type: Edge Article
DOI: 10.1039/C9SC00199A
Citation: Chem. Sci., 2019,10, 4673-4683
  • Open access: Creative Commons BY-NC license
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    Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

    D. R. Chisholm, R. Lamb, T. Pallett, V. Affleck, C. Holden, J. Marrison, P. O'Toole, P. D. Ashton, K. Newling, A. Steffen, A. K. Nelson, C. Mahler, R. Valentine, T. S. Blacker, A. J. Bain, J. Girkin, T. B. Marder, A. Whiting and C. A. Ambler, Chem. Sci., 2019, 10, 4673
    DOI: 10.1039/C9SC00199A

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      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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      [Original citation] - Published by The Royal Society of Chemistry.

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