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Themed collection New Talent

66 items
Perspective

Artificial supramolecular protein assemblies as functional high-order protein scaffolds

Artificial supramolecular protein assemblies can serve as novel high-order scaffolds that can display various functional proteins with defined valencies and organization, offering unprecedented functional bio-architectures.

Graphical abstract: Artificial supramolecular protein assemblies as functional high-order protein scaffolds
Open Access Review Article

Site-directed spin labeling of proteins for distance measurements in vitro and in cells

We here review strategies for site-directed spin labeling (SDSL) of proteins and discuss their potential for EPR distance measurements to study protein function in vitro and in cells.

Graphical abstract: Site-directed spin labeling of proteins for distance measurements in vitro and in cells
From the themed collection: New Talent
Review Article

Enantioselective polyene cyclizations

A comprehensive review covering the field of enantioselective polyene cyclizations.

Graphical abstract: Enantioselective polyene cyclizations
From the themed collection: New Talent
Review Article

Palladium catalysed meta-C–H functionalization reactions

The directing group assisted site selective C–H functionalization approach is having a continuous impact in the field of natural product synthesis, drug discovery and material sciences.

Graphical abstract: Palladium catalysed meta-C–H functionalization reactions
Open Access Review Article

Selective chemical labeling of proteins

Diverse bioorthogonal reactions and chemical tagging approaches for protein labeling are discussed and compared in this review.

Graphical abstract: Selective chemical labeling of proteins
From the themed collection: New Talent
Open Access Review Article

Recent developments in synthetic methods for benzo[b]heteroles

This review summarizes recent developments in synthetic methods for benzoheterole compounds of significant potential for applications in materials science.

Graphical abstract: Recent developments in synthetic methods for benzo[b]heteroles
From the themed collection: New Talent
Review Article

Nitropyrrole natural products: isolation, biosynthesis and total synthesis

A review of the isolation, biological activity, biosynthesis and chemical synthesis of nitropyrrole-containing natural products reported to date, including the pyrrolomycins, heronapyrroles and nitropyrrolins.

Graphical abstract: Nitropyrrole natural products: isolation, biosynthesis and total synthesis
From the themed collection: New Talent
Open Access Review Article

Trihaloethenes as versatile building blocks for organic synthesis

Trihaloethenes are versatile C2-building blocks that can be simply modified via addition, elimination and transition metal-catalyzed reactions.

Graphical abstract: Trihaloethenes as versatile building blocks for organic synthesis
From the themed collection: New Talent
Review Article

A new generation of chiral phase-transfer catalysts

A new generation of chiral phase-transfer catalysts is summarized.

Graphical abstract: A new generation of chiral phase-transfer catalysts
Open Access Review Article

Enantioselective oxidative boron Heck reactions

This review highlights the use of the oxidative boron Heck reaction in enantioselective Heck-type couplings.

Graphical abstract: Enantioselective oxidative boron Heck reactions
From the themed collection: New Talent
Open Access Communication

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

A simple synthesis of primary bromides from alkenes using HBr in AcOH and atmospheric oxygen as a radical initiator.

Graphical abstract: Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins
Communication

Investigation of the dynamic nature of 1,2-oxazines derived from peralkylcyclopentadiene and nitrosocarbonyl species

We have investigated the dynamic nature of 1,2-oxazines, which revealed broad tunability and potential for applications in covalent adaptable materials.

Graphical abstract: Investigation of the dynamic nature of 1,2-oxazines derived from peralkylcyclopentadiene and nitrosocarbonyl species
From the themed collection: New Talent
Communication

Synthesis of 4H-chromenes by an unexpected, K3PO4-mediated intramolecular Rauhut–Currier type reaction

The K3PO4-mediated intramolecular Rauhut-Currier type reaction of chalcones having an enoate moiety leading to the formation of 4H-chromenes in moderate to good yields is demonstrated.

Graphical abstract: Synthesis of 4H-chromenes by an unexpected, K3PO4-mediated intramolecular Rauhut–Currier type reaction
From the themed collection: New Talent
Open Access Communication

Protein-specific localization of a rhodamine-based calcium-sensor in living cells

A small synthetic calcium sensor that can be site-specifically coupled to any protein of interest in living cells by utilizing the bio-orthogonal HaloTag labeling strategy.

Graphical abstract: Protein-specific localization of a rhodamine-based calcium-sensor in living cells
From the themed collection: New Talent
Communication

First total synthesis of trehalose containing tetrasaccharides from Mycobacterium smegmatis

Total synthesis of three important trehalose containing tetrasaccharides isolated from Mycobacterium smegmatis is reported for the first time, using regioselective opening of benzylidene acetals and stereoselective glycosylations as key steps.

Graphical abstract: First total synthesis of trehalose containing tetrasaccharides from Mycobacterium smegmatis
From the themed collection: New Talent
Communication

Mechanistic studies on intramolecular C–H trifluoromethoxylation of (hetero)arenes via OCF3-migration

Intramolecular C–H trifluoromethoxylation of arenes and heteroarenes proceeds through a reaction mechanism of radical O-trifluoromethoxylation and ionic OCF3-migration.

Graphical abstract: Mechanistic studies on intramolecular C–H trifluoromethoxylation of (hetero)arenes via OCF3-migration
Communication

Facile synthesis of enantioenriched phenol-sulfoxides and their aluminum complexes

Chiral phenolic p-tolylsulfoxides, t-butylsulfoxides and well-defined aluminum complexes were prepared by short synthetic routes from readily available starting materials.

Graphical abstract: Facile synthesis of enantioenriched phenol-sulfoxides and their aluminum complexes
From the themed collection: New Talent
Communication

Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet–Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates

Thia-Pictet–Spengler cyclization is used for stereoselective synthesis of N-fused thiazinoindole derivatives. One-pot, sequential Friedel–Crafts alkylation – Pictet–Spengler cyclization and the synthesis of thiazino-oxepino-indole is developed.

Graphical abstract: Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet–Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates
From the themed collection: New Talent
Communication

A mild preparation of alkynes from alkenyl triflates

We report herein a protocol for preparing alkynes from alkenyl triflates at ambient temperature with LiCl as a promoter.

Graphical abstract: A mild preparation of alkynes from alkenyl triflates
From the themed collection: New Talent
Open Access Communication

Probing the self-assembly and stability of oligohistidine based rod-like micelles by aggregation induced luminescence

The synthesis and self-assembly of a new C2-symmetric oligohistidine amphiphile equipped with an aggregation induced emission luminophore is reported.

Graphical abstract: Probing the self-assembly and stability of oligohistidine based rod-like micelles by aggregation induced luminescence
From the themed collection: New Talent
Communication

Rhodium-catalyzed pyridannulation of indoles with diazoenals: a direct approach to pyrido[1,2-a]indoles

A new rhodium-catalyzed [4 + 2]-pyridannulation of 3-substituted indoles with diazoenals resulted in the biologically important pyrido[1,2-a]indoles.

Graphical abstract: Rhodium-catalyzed pyridannulation of indoles with diazoenals: a direct approach to pyrido[1,2-a]indoles
From the themed collection: New Talent
Open Access Communication

One-pot relay catalysis: divergent synthesis of furo[3,4-b]indoles and cyclopenta[b]indoles from 3-(2-aminophenyl)-1,4-enynols

Described herein a divergent strategy for the synthesis of furo[3,4-b]indoles via a sequential Ag(I)/Bi(III)/Pd(II) catalysis and cyclopenta[b]indoles via a one-pot Ag(I)/Brønsted acid relay catalysis, starting from the easily accessible 3-(2 aminophenyl)-4-pentenyn-3-ols.

Graphical abstract: One-pot relay catalysis: divergent synthesis of furo[3,4-b]indoles and cyclopenta[b]indoles from 3-(2-aminophenyl)-1,4-enynols
From the themed collection: New Talent
Communication

Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue

Diphosphoinositol polyphosphates (inositol pyrophosphates, X-InsP7) are a family of second messengers with important roles in eukaryotic biology. A new approach targeting 2-InsP7 and a photocaged analogue is described.

Graphical abstract: Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue
From the themed collection: New Talent
Communication

Ruthenium photoredox-triggered phospholipid membrane formation

As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs.

Graphical abstract: Ruthenium photoredox-triggered phospholipid membrane formation
From the themed collection: New Talent
Communication

Some chemical speculation on the biosynthesis of corallidictyals A–D

The efficient conversion of siphonodictyal B into the spirocyclic natural products corallidictyals A–D has been achieved via oxidative and acid catalyzed cyclizations.

Graphical abstract: Some chemical speculation on the biosynthesis of corallidictyals A–D
From the themed collection: New Talent
Communication

N-Heterocyclic carbene catalysed 1,6-hydrophosphonylation of p-quinone methides and fuchsones: an atom economical route to unsymmetrical diaryl- and triarylmethyl phosphonates

A direct method for the synthesis of diaryl- and triarylmethyl phosphonates through 1,6-hydrophosphonylation of p-quinone methides and fuchsones using NHC as a Brønsted base catalyst is described.

Graphical abstract: N-Heterocyclic carbene catalysed 1,6-hydrophosphonylation of p-quinone methides and fuchsones: an atom economical route to unsymmetrical diaryl- and triarylmethyl phosphonates
From the themed collection: New Talent
Open Access Communication

Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant

We use kinetic data, photophysical properties, and mechanistic analyses to compare recently developed high-rate constant oxime and hydrazone formations.

Graphical abstract: Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant
From the themed collection: New Talent
Open Access Communication

3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)–H bond functionalization of 2-alkylazaarenes

A Brønsted acid-catalyzed addition of 2-alkylazaarenes to in situ generated N-sulfonylimines through selective C(sp3)–H bond functionalization has been developed.

Graphical abstract: 3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)–H bond functionalization of 2-alkylazaarenes
From the themed collection: New Talent
Open Access Communication

Phage-displayed macrocyclic glycopeptide libraries

In this report, we describe an efficient way to generate libraries of macrocyclic glycopeptides in one step by reacting phage-displayed libraries of peptides with dichloro-oxime derivatives.

Graphical abstract: Phage-displayed macrocyclic glycopeptide libraries
From the themed collection: New Talent
Communication

Direct synthesis of anilines and nitrosobenzenes from phenols

A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process.

Graphical abstract: Direct synthesis of anilines and nitrosobenzenes from phenols
From the themed collection: New Talent
Communication

Fluorine-directed 1,2-trans glycosylation of rare sugars

To reconcile the urgent need to access well defined β-configured 2,6-di-deoxypyranose analogues for chemical biology, with the intrinsic α-selectivity of the native system, the directing role of fluorine at C2 has been explored.

Graphical abstract: Fluorine-directed 1,2-trans glycosylation of rare sugars
From the themed collection: New Talent
Communication

Palladium-catalyzed β-C(sp3)–H arylation of phthaloyl alanine with hindered aryl iodides: synthesis of complex β-aryl α-amino acids

An efficient protocol for palladium-catalyzed PE auxiliary-directed C(sp3)–H arylation reaction with sterically hindered aryl iodides was developed.

Graphical abstract: Palladium-catalyzed β-C(sp3)–H arylation of phthaloyl alanine with hindered aryl iodides: synthesis of complex β-aryl α-amino acids
From the themed collection: New Talent
Communication

Iron-catalyzed arylation of α-aryl-α-diazoesters

An iron-catalyzed arylation of α-aryl-α-diazoesters with electron-rich benzene rings was developed, which provides an efficient method for the preparation of 1,1-diarylacetates with high yields and excellent chemo- and regio-selectivities.

Graphical abstract: Iron-catalyzed arylation of α-aryl-α-diazoesters
From the themed collection: New Talent
Communication

A highly enantioselective Hg(II)-catalyzed Sakurai–Hosomi reaction of isatins with allyltrimethylsilanes

A chiral complex derived from (S)-difluorophos and Hg(OTf)2 is identified as a powerful catalyst for the Sakurai–Hosomi reaction of isatins with allyltrimethylsilane, allowing the facile synthesis of valuable building blocks 3-allyl-3-hydroxyoxindoles in up to 97% ee, with only 0.5–1.0 mol% of catalyst loading.

Graphical abstract: A highly enantioselective Hg(ii)-catalyzed Sakurai–Hosomi reaction of isatins with allyltrimethylsilanes
Communication

Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1)

A novel Mcl-1 inhibitor chemotype based on a tetrahydroquinoline carboxylic acid was developed utilizing structure-based design, which was subsequently validated by a fluorescence polarization competition assay and HSQC NMR analysis.

Graphical abstract: Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1)
From the themed collection: New Talent
Communication

Rawal's catalyst as an effective stimulant for the highly asymmetric Michael addition of β-keto esters to functionally rich nitro-olefins

A general approach to the asymmetric synthesis of highly substituted dihydroquinolines was achieved through neighboring ortho-amino group engaged sequential Michael/amination/dehydration reactions.

Graphical abstract: Rawal's catalyst as an effective stimulant for the highly asymmetric Michael addition of β-keto esters to functionally rich nitro-olefins
From the themed collection: New Talent
Communication

Iron-catalyzed transfer hydrogenation of imines assisted by an iron-based Lewis acid

An iron-catalyzed transfer hydrogenation of N-aryl and N-alkyl imines using isopropanol as the hydrogen donor is reported for the first time.

Graphical abstract: Iron-catalyzed transfer hydrogenation of imines assisted by an iron-based Lewis acid
From the themed collection: New Talent
Communication

Copper-catalyzed electrophilic amination using N-methoxyamines

Copper-catalyzed electrophilic amination using functionalized N-methoxyamines, prepared by nucleophilic addition to N-methoxyamides, is reported.

Graphical abstract: Copper-catalyzed electrophilic amination using N-methoxyamines
Communication

Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented.

Graphical abstract: Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes
From the themed collection: New Talent
Communication

anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(III) reagents

anti-Aminofluorination of alkenes with amidines was enabled by hypervalent iodine(III) reagents, affording 4-fluoroalkyl-2-imidazolines. Further reductive ring-opening of the 2-imidazoline moiety could deliver highly functionalized 3-fluoropropane-1,2-diamine derivatives.

Graphical abstract: anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(iii) reagents
Paper

Expedient synthesis of densely substituted pyrrolo[1,2-a]indoles

The strategy was further applied for the synthesis of optically active pyrrolo[1,2-a]indoles in >97% de using the chiral auxiliary based approach.

Graphical abstract: Expedient synthesis of densely substituted pyrrolo[1,2-a]indoles
From the themed collection: New Talent
Paper

A clickable UTP analog for the posttranscriptional chemical labeling and imaging of RNA

A multipurpose UTP analog potentially suitable for RNA aptamer selection and two-channel visualization of RNA in cells by using click chemistry and Raman spectroscopy has been developed.

Graphical abstract: A clickable UTP analog for the posttranscriptional chemical labeling and imaging of RNA
From the themed collection: New Talent
Paper

Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A

The effectiveness of computational tools in determining relative configurations of complex molecules is investigated, using natural products mandelalides A–D and coibamide A, towards a generalized recipe for the scientific community at large.

Graphical abstract: Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A
From the themed collection: New Talent
Open Access Paper

C2-Alkenylation of N-heteroaromatic compounds via Brønsted acid catalysis

C2-alkenylated heteroaromatics can be accessed by simple Brønsted acid catalysed union of diverse heteroarene N-oxides with alkenes. The scope and limitations of the process are outlined.

Graphical abstract: C2-Alkenylation of N-heteroaromatic compounds via Brønsted acid catalysis
From the themed collection: New Talent
Paper

The effect of photoisomerization on the enzymatic hydrolysis of polymeric micelles bearing photo-responsive azobenzene groups at their cores

Photoisomerization boosts the enzymatic disassembly of smart polymeric micelles based on amphiphilic PEG–dendron hybrids bearing enzymatically cleavable azobenzene end-groups.

Graphical abstract: The effect of photoisomerization on the enzymatic hydrolysis of polymeric micelles bearing photo-responsive azobenzene groups at their cores
From the themed collection: New Talent
Paper

Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids

A strategy for the production of side-chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported.

Graphical abstract: Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids
From the themed collection: New Talent
Open Access Paper

Asymmetric nucleophilic dearomatization of diazarenes by anion-binding catalysis

The first highly regio- and enantioselective nucleophilic dearomatization of diazarenes by anion-binding organocatalysis is reported.

Graphical abstract: Asymmetric nucleophilic dearomatization of diazarenes by anion-binding catalysis
From the themed collection: New Talent
Open Access Paper

Conformational diversity and enantioconvergence in potato epoxide hydrolase 1

Computational studies highlight the importance of conformational diversity in the enantioconvergent hydrolysis of styrene oxide by potato epoxide hydrolase 1.

Graphical abstract: Conformational diversity and enantioconvergence in potato epoxide hydrolase 1
From the themed collection: New Talent
Paper

Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding

This paper describes the synthesis of polymers and silica nanoparticles, both bearing polystyrene sulfonate brushes, and the measurement of their binding affinity for the chemokine monocyte chemoattractant protein-1 (MCP-1) in monomeric and dimeric form.

Graphical abstract: Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding
From the themed collection: New Talent
Paper

Versatile, mild, and selective reduction of various carbonyl groups using an electron-deficient boron catalyst

Acetanilides and nitriles are mildly and selectively reduced over various other carbonyl derivatives using an electron-deficient boron catalyst and triethylsilane.

Graphical abstract: Versatile, mild, and selective reduction of various carbonyl groups using an electron-deficient boron catalyst
From the themed collection: New Talent
Paper

Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein

Side-chain cyclization has a consistent effect on protein folding energetics, and the identity of the cross-linking moiety determines the magnitude of stabilization.

Graphical abstract: Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein
From the themed collection: New Talent
Paper

Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs

The stabilization of G-quadruplex DNA structures by using small molecule ligands having simple structural scaffolds has the potential to be harnessed for developing next generation anticancer agents.

Graphical abstract: Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs
From the themed collection: New Talent
Paper

Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives

Herein we report the design, synthesis, biophysical and biological evaluation of triazole containing prolinamide derivatives as selective c-MYC G-quadruplex binding ligands.

Graphical abstract: Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives
From the themed collection: New Talent
Paper

In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

Molecular imaging visualized significantly reduced clearance of AGE-albumin.

Graphical abstract: In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice
From the themed collection: New Talent
Paper

Chiral phosphoric acid catalyzed asymmetric addition of naphthols to para-quinone methides

An asymmetric addition of naphthols to in situ generated para-quinone methides catalyzed by a chiral phosphoric acid is described.

Graphical abstract: Chiral phosphoric acid catalyzed asymmetric addition of naphthols to para-quinone methides
Paper

Light-triggered assembly–disassembly of an ordered donor–acceptor π-stack using a photoresponsive dimethyldihydropyrene π-switch

A dimethyldihydropyrene based photochromic π-switch in its closed state forms donor–acceptor stacks with 1,4,5,8-naphthalenetetracarboxylic dianhydride. The stacks collapse in the photoisomeric open form.

Graphical abstract: Light-triggered assembly–disassembly of an ordered donor–acceptor π-stack using a photoresponsive dimethyldihydropyrene π-switch
From the themed collection: New Talent
Paper

Synthetic studies towards putative yuremamine using an iterative C(sp3)–H arylation strategy

An overview of synthetic efforts toward the initially proposed structure of yuremamine using iterative C(sp3)–H arylations is described.

Graphical abstract: Synthetic studies towards putative yuremamine using an iterative C(sp3)–H arylation strategy
From the themed collection: New Talent
Paper

Palladium-catalyzed Suzuki–Miyaura coupling of amides by carbon–nitrogen cleavage: general strategy for amide N–C bond activation

A unified strategy for the palladium-catalyzed Suzuki–Miyaura cross-coupling of amides with boronic acids for the synthesis of ketones by N–C bond activation is reported.

Graphical abstract: Palladium-catalyzed Suzuki–Miyaura coupling of amides by carbon–nitrogen cleavage: general strategy for amide N–C bond activation
From the themed collection: New Talent
Paper

Reversible morphological changes of assembled supramolecular amphiphiles triggered by pH-modulated host–guest interactions

Acid–base modulated host–guest binding at the micellar–water interface triggers reversible oblate ellipsoid-to-lamellar morphological transitions revealing the relationship between Image ID:c6ob00109b-t1.gif and morphology.

Graphical abstract: Reversible morphological changes of assembled supramolecular amphiphiles triggered by pH-modulated host–guest interactions
From the themed collection: New Talent
Paper

Green organocatalytic α-hydroxylation of ketones

An efficient and green method for the α-hydroxylation of substituted ketones has been developed.

Graphical abstract: Green organocatalytic α-hydroxylation of ketones
From the themed collection: New Talent
Paper

Synthesis and characterization of a highly strained donor–acceptor nanohoop

A highly-strained, nitrogen-doped cycloparaphenylene (CPP), aza[6]CPP, was synthesized and then converted to a donor–acceptor nanohoop, N-methylaza[6]CPP, via alkylation of the nitrogen center.

Graphical abstract: Synthesis and characterization of a highly strained donor–acceptor nanohoop
Paper

I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement

A simple and efficient iodine-assisted protocol for synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones has been developed.

Graphical abstract: I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement
From the themed collection: New Talent
Open Access Paper

Direct conjugate alkylation of α,β-unsaturated carbonyls by TiIII-catalysed reductive umpolung of simple activated alkenes

The title reaction leads to 1,6-difunctionalized products without the requirement of premetallated reagents. Details on scope, selectivity and mechanism are reported.

Graphical abstract: Direct conjugate alkylation of α,β-unsaturated carbonyls by TiIII-catalysed reductive umpolung of simple activated alkenes
From the themed collection: New Talent
Paper

A convenient domino Ferrier rearrangement-intramolecular cyclization for the synthesis of novel benzopyran-fused pyranoquinolines

Lewis acid-mediated three component coupling of salicyladehydes, anilines and gylcals provided novel benzopyran-fused pyranoquinolines stereoselectively, in moderate to high yields.

Graphical abstract: A convenient domino Ferrier rearrangement-intramolecular cyclization for the synthesis of novel benzopyran-fused pyranoquinolines
From the themed collection: New Talent
Paper

A versatile synthesis of chiral β-aminophosphines

A protocol for the synthesis of chiral β-aminophosphines by ring-opening of cyclic sulfamidates with metallated secondary phosphine oxides is described. It allows access to previously unknown derivatives having electron-deficient, electron-rich and sterically hindered P-aryl substituents.

Graphical abstract: A versatile synthesis of chiral β-aminophosphines
From the themed collection: New Talent
Paper

Catalytic asymmetric formal γ-allylation of deconjugated butenolides

A formal γ-allylation of deconjugated butenolides is reported based on a two-step sequence consisting of a catalytic diastereo- and enantioselective vinylogous nucleophilic addition to vinyl sulfones and Julia–Kocienski olefination. This highly modular approach delivers densely functionalized butenolides containing a quaternary stereogenic centre in excellent yield with high enantioselectivity.

Graphical abstract: Catalytic asymmetric formal γ-allylation of deconjugated butenolides
From the themed collection: New Talent
66 items

About this collection

This issue aims to highlight the excellent work being carried out by younger members of the research community.

It will cover topics including organic synthesis, physical organic chemistry, supramolecular chemistry and chemical biology, and showcase the strength of research being carried out by tomorrow's leaders in the field.

Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.

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