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Issue 24, 2016
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Iron-catalyzed transfer hydrogenation of imines assisted by an iron-based Lewis acid

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Abstract

An iron-catalyzed transfer hydrogenation of N-aryl and N-alkyl imines using isopropanol as the hydrogen donor is reported for the first time. A combination of two iron complexes serving different roles is the key for the success of this catalytic system. As a result, an environmentally friendly and precious metal-free transfer hydrogenation of imines has been developed. The use of a suitable co-catalyst as an activator not only led to efficient transfer hydrogenation, but also showed potential in enantioselective transformation.

Graphical abstract: Iron-catalyzed transfer hydrogenation of imines assisted by an iron-based Lewis acid

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 13 Oct 2015, accepted on 03 Nov 2015 and first published on 03 Nov 2015


Article type: Communication
DOI: 10.1039/C5OB02119G
Citation: Org. Biomol. Chem., 2016,14, 5490-5493
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    Iron-catalyzed transfer hydrogenation of imines assisted by an iron-based Lewis acid

    H. Pan, T. W. Ng and Y. Zhao, Org. Biomol. Chem., 2016, 14, 5490
    DOI: 10.1039/C5OB02119G

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